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The Journal of Neuroscience, November 12, 2003, 23(32):10238-10248
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Cellular/Molecular
Long-Term Enhancement of Neuronal Excitability and Temporal Fidelity Mediated by Metabotropic Glutamate Receptor Subtype 5
Valérie Sourdet, * Michaël Russier, * Gaël Daoudal, Norbert Ankri, andDominique Debanne Neurobiologie des Canaux Ioniques, Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 464, Institut Fédératif de Recherche Jean Roche, Universitéde la Méditerranée, F-13916 Marseille Cedex 20, France
The cellular substrate for memory is generally attributed to long-lasting changes in synaptic strength. We report here that synaptic or pharmacological activation of the metabotropic glutamate receptor subtype 5 (mGluR5) induces long-term potentiation of intrinsic excitability (LTP-IE) in layer V pyramidal neurons. mGluR5-dependent LTP-IE was associated with a persistent reduction of the afterhyperpolarization (AHP) outward current (IAHP), resulting in the potentiation of EPSP-spike coupling. Apamin occluded induction of LTP-IE, indicating that downregulation of small conductance calcium-dependent potassium (SK) channels mediates this process. In addition to the improved reliability of the input-output function, LTP-IE led to increased temporal precision. The induced reduction of IAHP accelerated the rate of membrane depolarization preceding each action potential and subsequently decreased the jitter of the neuronal discharge. We conclude that mGluR5-dependent LTP-IE not only promotes the spread of excitation in the cortical network but also persistently enhances the temporal fidelity of the neuronal message.
Key words: long-term potentiation; neocortex; excitability; temporal precision; mGluR5; reliability
Received July 30, 2003; revised September 22, 2003; accepted September 22, 2003.
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