 |
||||
|
||||
|
||||
|
||||
|
||||
The Journal of Neuroscience, November 12, 2003, 23(32):10238-10248
Previous Article | Next Article
Cellular/Molecular
Long-Term Enhancement of Neuronal Excitability and Temporal Fidelity Mediated by Metabotropic Glutamate Receptor Subtype 5
Valérie Sourdet, * Michaël Russier, * Gaël Daoudal, Norbert Ankri, andDominique Debanne Neurobiologie des Canaux Ioniques, Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 464, Institut Fédératif de Recherche Jean Roche, Universitéde la Méditerranée, F-13916 Marseille Cedex 20, France
The cellular substrate for memory is generally attributed to long-lasting changes in synaptic strength. We report here that synaptic or pharmacological activation of the metabotropic glutamate receptor subtype 5 (mGluR5) induces long-term potentiation of intrinsic excitability (LTP-IE) in layer V pyramidal neurons. mGluR5-dependent LTP-IE was associated with a persistent reduction of the afterhyperpolarization (AHP) outward current (IAHP), resulting in the potentiation of EPSP-spike coupling. Apamin occluded induction of LTP-IE, indicating that downregulation of small conductance calcium-dependent potassium (SK) channels mediates this process. In addition to the improved reliability of the input-output function, LTP-IE led to increased temporal precision. The induced reduction of IAHP accelerated the rate of membrane depolarization preceding each action potential and subsequently decreased the jitter of the neuronal discharge. We conclude that mGluR5-dependent LTP-IE not only promotes the spread of excitation in the cortical network but also persistently enhances the temporal fidelity of the neuronal message.
Key words: long-term potentiation; neocortex; excitability; temporal precision; mGluR5; reliability
Received July 30, 2003; revised September 22, 2003; accepted September 22, 2003.
This article has been cited by other articles:
J. T. Paz, Sév. Mahon, P. Tiret, S.ép. Genet, B. Delord, and S.ép. Charpier
Multiple forms of activity-dependent intrinsic plasticity in layer V cortical neurones in vivo
J. Physiol., July 1, 2009; 587(13): 3189 - 3205.
[Abstract] [Full Text] [PDF]
M. D\#8217;Ascenzo, M. V. Podda, T. Fellin, G. B. Azzena, P. Haydon, and C. Grassi
Activation of mGluR5 induces spike afterdepolarization and enhanced excitability in medium spiny neurons of the nucleus accumbens by modulating persistent Na+ currents
J. Physiol., July 1, 2009; 587(13): 3233 - 3250.
[Abstract] [Full Text] [PDF]
M. Ishikawa, P. Mu, J. T. Moyer, J. A. Wolf, R. M. Quock, N. M. Davies, X.-t. Hu, O. M. Schluter, and Y. Dong
Homeostatic Synapse-Driven Membrane Plasticity in Nucleus Accumbens Neurons
J. Neurosci., May 6, 2009; 29(18): 5820 - 5831.
[Abstract] [Full Text] [PDF]
W. Francesconi, F. Berton, V. Repunte-Canonigo, K. Hagihara, D. Thurbon, D. Lekic, S. E. Specio, T. N. Greenwell, S. A. Chen, K. C. Rice, et al.
Protracted Withdrawal from Alcohol and Drugs of Abuse Impairs Long-Term Potentiation of Intrinsic Excitability in the Juxtacapsular Bed Nucleus of the Stria Terminalis
J. Neurosci., April 29, 2009; 29(17): 5389 - 5401.
[Abstract] [Full Text] [PDF]
S. F. Santos, N. Pierrot, N. Morel, P. Gailly, C. Sindic, and J.-N. Octave
Expression of Human Amyloid Precursor Protein in Rat Cortical Neurons Inhibits Calcium Oscillations
J. Neurosci., April 15, 2009; 29(15): 4708 - 4718.
[Abstract] [Full Text] [PDF]
J. T. Brown and A. D. Randall
Activity-dependent depression of the spike after-depolarization generates long-lasting intrinsic plasticity in hippocampal CA3 pyramidal neurons
J. Physiol., March 15, 2009; 587(6): 1265 - 1281.
[Abstract] [Full Text] [PDF]
P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser
Dendritic Excitability and Synaptic Plasticity
Physiol Rev, April 1, 2008; 88(2): 769 - 840.
[Abstract] [Full Text] [PDF]
S. R. Young, R. Bianchi, and R. K. S. Wong
Signaling Mechanisms Underlying Group I mGluR-Induced Persistent AHP Suppression in CA3 Hippocampal Neurons
J Neurophysiol, March 1, 2008; 99(3): 1105 - 1118.
[Abstract] [Full Text] [PDF]
B. D. Burrell and K. M. Crisp
Serotonergic Modulation of Afterhyperpolarization in a Neuron That Contributes to Learning in the Leech
J Neurophysiol, February 1, 2008; 99(2): 605 - 616.
[Abstract] [Full Text] [PDF]
E. Campanac and D. Debanne
Spike timing-dependent plasticity: a learning rule for dendritic integration in rat CA1 pyramidal neurons
J. Physiol., February 1, 2008; 586(3): 779 - 793.
[Abstract] [Full Text] [PDF]
M. Diaz-Rios, D. A. Dombeck, W. W. Webb, and R. M. Harris-Warrick
Serotonin Modulates Dendritic Calcium Influx in Commissural Interneurons in the Mouse Spinal Locomotor Network
J Neurophysiol, October 1, 2007; 98(4): 2157 - 2167.
[Abstract] [Full Text] [PDF]
S. E. Street and P. B. Manis
Action Potential Timing Precision in Dorsal Cochlear Nucleus Pyramidal Cells
J Neurophysiol, June 1, 2007; 97(6): 4162 - 4172.
[Abstract] [Full Text] [PDF]
L. Chen, J. D. Bohanick, M. Nishihara, J. K. Seamans, and C. R. Yang
Dopamine D1/5 Receptor-Mediated Long-Term Potentiation of Intrinsic Excitability in Rat Prefrontal Cortical Neurons: Ca2+-Dependent Intracellular Signaling
J Neurophysiol, March 1, 2007; 97(3): 2448 - 2464.
[Abstract] [Full Text] [PDF]
B. M. Wilson and C. L. Cox
Absence of metabotropic glutamate receptor-mediated plasticity in the neocortex of fragile X mice
PNAS, February 13, 2007; 104(7): 2454 - 2459.
[Abstract] [Full Text] [PDF]
C. C. Kaczorowski, J. Disterhoft, and N. Spruston
Stability and plasticity of intrinsic membrane properties in hippocampal CA1 pyramidal neurons: effects of internal anions
J. Physiol., February 1, 2007; 578(3): 799 - 818.
[Abstract] [Full Text] [PDF]
E. Carlier, V. Sourdet, S. Boudkkazi, P. Deglise, N. Ankri, L. Fronzaroli-Molinieres, and D. Debanne
Metabotropic glutamate receptor subtype 1 regulates sodium currents in rat neocortical pyramidal neurons
J. Physiol., November 15, 2006; 577(1): 141 - 154.
[Abstract] [Full Text] [PDF]
N. S. Desai, T. M. Casimiro, S. M. Gruber, and P. W. Vanderklish
Early Postnatal Plasticity in Neocortex of Fmr1 Knockout Mice
J Neurophysiol, October 1, 2006; 96(4): 1734 - 1745.
[Abstract] [Full Text] [PDF]
I. Brosh, K. Rosenblum, and E. Barkai
Learning-Induced Reversal of the Effect of Noradrenalin on the Postburst AHP
J Neurophysiol, October 1, 2006; 96(4): 1728 - 1733.
[Abstract] [Full Text] [PDF]
J. R. Gibson, A. F. Bartley, and K. M. Huber
Role for the Subthreshold Currents ILeak and IH in the Homeostatic Control of Excitability in Neocortical Somatostatin-Positive Inhibitory Neurons
J Neurophysiol, July 1, 2006; 96(1): 420 - 432.
[Abstract] [Full Text] [PDF]
G. Zhong, M. Diaz-Rios, and R. M. Harris-Warrick
Intrinsic and functional differences among commissural interneurons during fictive locomotion and serotonergic modulation in the neonatal mouse.
J. Neurosci., June 14, 2006; 26(24): 6509 - 6517.
[Abstract] [Full Text] [PDF]
N. S. Desai and E. C. Walcott
Synaptic bombardment modulates muscarinic effects in forelimb motor cortex.
J. Neurosci., February 22, 2006; 26(8): 2215 - 2226.
[Abstract] [Full Text] [PDF]
P. W. Hickmott
Changes in Intrinsic Properties of Pyramidal Neurons in Adult Rat S1 During Cortical Reorganization
J Neurophysiol, July 1, 2005; 94(1): 501 - 511.
[Abstract] [Full Text] [PDF]
S.-W. Ying and P. A. Goldstein
Propofol-Block of SK Channels in Reticular Thalamic Neurons Enhances GABAergic Inhibition in Relay Neurons
J Neurophysiol, April 1, 2005; 93(4): 1935 - 1948.
[Abstract] [Full Text] [PDF]
J. Xu, N. Kang, L. Jiang, M. Nedergaard, and J. Kang
Activity-Dependent Long-Term Potentiation of Intrinsic Excitability in Hippocampal CA1 Pyramidal Neurons
J. Neurosci., February 16, 2005; 25(7): 1750 - 1760.
[Abstract] [Full Text] [PDF]
A. Aschrafi, B. A. Cunningham, G. M. Edelman, and P. W. Vanderklish
The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brain
PNAS, February 8, 2005; 102(6): 2180 - 2185.
[Abstract] [Full Text] [PDF]
W. Zhang, J. H. Shin, and D. J Linden
Persistent changes in the intrinsic excitability of rat deep cerebellar nuclear neurones induced by EPSP or IPSP bursts
J. Physiol., December 15, 2004; 561(3): 703 - 719.
[Abstract] [Full Text] [PDF]
D. R. Ireland, D. Guevremont, J. M. Williams, and W. C. Abraham
Metabotropic Glutamate Receptor-Mediated Depression of the Slow Afterhyperpolarization Is Gated by Tyrosine Phosphatases in Hippocampal CA1 Pyramidal Neurons
J Neurophysiol, November 1, 2004; 92(5): 2811 - 2819.
[Abstract] [Full Text] [PDF]
C. P. Marder and D. V. Buonomano
Timing and Balance of Inhibition Enhance the Effect of Long-Term Potentiation on Cell Firing
J. Neurosci., October 6, 2004; 24(40): 8873 - 8884.
[Abstract] [Full Text] [PDF]
M. Maravall, E. A. Stern, and K. Svoboda
Development of Intrinsic Properties and Excitability of Layer 2/3 Pyramidal Neurons During a Critical Period for Sensory Maps in Rat Barrel Cortex
J Neurophysiol, July 1, 2004; 92(1): 144 - 156.
[Abstract] [Full Text] [PDF]
R. H. Cudmore and G. G. Turrigiano
Long-Term Potentiation of Intrinsic Excitability in LV Visual Cortical Neurons
J Neurophysiol, July 1, 2004; 92(1): 341 - 348.
[Abstract] [Full Text] [PDF]
G. Daoudal and D. Debanne
Long-Term Plasticity of Intrinsic Excitability: Learning Rules and Mechanisms
Learn. Mem., November 1, 2003; 10(6): 456 - 465.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|