QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, November 12, 2003, 23(32):10419-10432

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (38) Citing Articles via Google Scholar Google Scholar Articles by Law, J. W. S. Articles by Morellini, F. Search for Related Content PubMed PubMed Citation Articles by Law, J. W. S. Articles by Morellini, F.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Decreased Anxiety, Altered Place Learning, and Increased CA1 Basal Excitatory Synaptic Transmission in Mice with Conditional Ablation of the Neural Cell Adhesion Molecule L1

Janice W. S. Law,^1,2 Alan Y. W. Lee,¹ Mu Sun,¹ Alexander G. Nikonenko,¹ Sookja K. Chung,² Alexander Dityatev,¹ Melitta Schachner,¹ and Fabio Morellini¹

¹Zentrum für Molekulare Neurobiologie, Universität Hamburg, D-20246 Hamburg, Germany, and ²Institute of Molecular Biology, The University of Hong Kong, Pokfulam, Hong Kong, China

L1, a neural cell adhesion molecule of the immunoglobulin superfamily, is involved in neuronal migration and differentiation and axon outgrowth and guidance. Mutations in the human and mouse L1 gene result in similarly severe neurological abnormalities. To dissociate the functional roles of L1 in the adult brain from developmental abnormalities, we have generated a mutant in which the L1 gene is inactivated by cre-recombinase under the control of the calcium/calmodulin-dependent kinase II promoter. This mutant (L1fy+) did not show the overt morphological and behavioral abnormalities observed previously in constitutive L1-deficient (L1-/-) mice; however, there was an increase in basal excitatory synaptic transmission that was not apparent in L1-/- mice. Similar to L1-/- mice, no defects in short- and long-term potentiation in the CA1 region of the hippocampus were observed. Interestingly, L1fy+ mice showed decreased anxiety in the open field and elevated plus-maze, contrary to L1-/- mice, and altered place learning in the water maze, similar to L1-/- mice. Thus, mice conditionally deficient in L1 expression in the adult brain share some abnormalities, but also display different ones, as compared with L1-/- mice, highlighting the role of L1 in the regulation of synaptic transmission and behavior in adulthood.

Key words: anxiety; cell adhesion molecule; hippocampus; L1; place learning; synaptic plasticity

---

Received March 17, 2003; revised September 3, 2002; accepted September 5, 2003.

This article has been cited by other articles:

				L. Maddaluno, S. E. Verbrugge, C. Martinoli, G. Matteoli, A. Chiavelli, Y. Zeng, E. D. Williams, M. Rescigno, and U. Cavallaro The adhesion molecule L1 regulates transendothelial migration and trafficking of dendritic cells J. Exp. Med., March 16, 2009; 206(3): 623 - 635. [Abstract] [Full Text] [PDF]

				S. Kolata, J. Wu, K. Light, M. Schachner, and L. D. Matzel Impaired Working Memory Duration But Normal Learning Abilities Found in Mice That Are Conditionally Deficient in the Close Homolog of L1 J. Neurosci., December 10, 2008; 28(50): 13505 - 13510. [Abstract] [Full Text] [PDF]

				I. Morita, Y. Kizuka, S. Kakuda, and S. Oka Expression and Function of the HNK-1 Carbohydrate J. Biochem., June 1, 2008; 143(6): 719 - 724. [Abstract] [Full Text] [PDF]

				M. Sun, M. J. Thomas, R. Herder, M. L. Bofenkamp, S. B. Selleck, and M. B. O'Connor Presynaptic Contributions of Chordin to Hippocampal Plasticity and Spatial Learning J. Neurosci., July 18, 2007; 27(29): 7740 - 7750. [Abstract] [Full Text] [PDF]

				J. Chen, J. Wu, I. Apostolova, M. Skup, A. Irintchev, S. Kugler, and M. Schachner Adeno-associated virus-mediated L1 expression promotes functional recovery after spinal cord injury Brain, April 1, 2007; 130(4): 954 - 969. [Abstract] [Full Text] [PDF]

				C. Bernreuther, M. Dihne, V. Johann, J. Schiefer, Y. Cui, G. Hargus, J. S. Schmid, J. Xu, C. M. Kosinski, and M. Schachner Neural Cell Adhesion Molecule L1-Transfected Embryonic Stem Cells Promote Functional Recovery after Excitotoxic Lesion of the Mouse Striatum. J. Neurosci., November 8, 2006; 26(45): 11532 - 11539. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help