QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, November 19, 2003, 23(33):10585-10592

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (17) Citing Articles via Google Scholar Google Scholar Articles by Zhang, H. Articles by Sulzer, D. Search for Related Content PubMed PubMed Citation Articles by Zhang, H. Articles by Sulzer, D.

 Previous Article  |  Next Article 

Cellular/Molecular
Glutamate Spillover in the Striatum Depresses Dopaminergic Transmission by Activating Group I Metabotropic Glutamate Receptors

Hui Zhang¹ and David Sulzer^1,2,3

Departments of ¹Neurology and ²Psychiatry, Columbia University, New York, New York 10032, and ³Department of Neuroscience, New York State Psychiatric Institute, New York, New York 10032

Cortical glutamate and substantia nigra dopamine (DA) afferents converge onto the dendritic spines of medium spiny neurons (MSNs) in the striatum where they act to modulate motor and cognitive functions. The released DA spills over from its synapse and is thought to regulate glutamatergic input by acting on distal DA receptors located on corticostriatal axon terminals. By monitoring evoked DA release directly using fast-scan cyclic voltammetry, we report a reciprocal modulation by glutamate spillover on evoked striatal DA release, induced by either glutamate uptake blockade or high-frequency stimulation of corticostriatal tracts. We demonstrate that this modulation is attributable to the activation of group I metabotropic glutamate receptors. Thus, under conditions in which glutamate escapes the confines of its synapse, it can elicit the presynaptic suppression of dopaminergic neurotransmission.

Key words: corticostriatal; glutamate spillover; EAATs blockers; dopamine; cyclic voltammetry; mGluRs; striatal slice

---

Received June 25, 2003; revised September 9, 2003; accepted September 22, 2003.

This article has been cited by other articles:

				Y. Schmitz, J. Luccarelli, M. Kim, M. Wang, and D. Sulzer Glutamate Controls Growth Rate and Branching of Dopaminergic Axons J. Neurosci., September 23, 2009; 29(38): 11973 - 11981. [Abstract] [Full Text] [PDF]

				G. J. Lyon, A. Abi-Dargham, H. Moore, J. A. Lieberman, J. A. Javitch, and D. Sulzer Presynaptic Regulation of Dopamine Transmission in Schizophrenia Schizophr Bull, June 12, 2009; (2009) sbp010v1. [Abstract] [Full Text] [PDF]

				J. C. Patel, P. Witkovsky, M. V. Avshalumov, and M. E. Rice Mobilization of Calcium from Intracellular Stores Facilitates Somatodendritic Dopamine Release J. Neurosci., May 20, 2009; 29(20): 6568 - 6579. [Abstract] [Full Text] [PDF]

				F. Ferraguti, L. Crepaldi, and F. Nicoletti Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives Pharmacol. Rev., December 1, 2008; 60(4): 536 - 581. [Abstract] [Full Text] [PDF]

				Y.-H. Chen, B. K. Harvey, A. F. Hoffman, Y. Wang, Y.-H. Chiang, and C. R. Lupica MPTP-induced deficits in striatal synaptic plasticity are prevented by glial cell line-derived neurotrophic factor expressed via an adeno-associated viral vector FASEB J, January 1, 2008; 22(1): 261 - 275. [Abstract] [Full Text] [PDF]

				G. Garraux, P. Peigneux, R. E. Carson, and M. Hallett Task-Related Interaction between Basal Ganglia and Cortical Dopamine Release J. Neurosci., December 26, 2007; 27(52): 14434 - 14441. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help