QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Related articles in J. Neurosci. Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (29) Citing Articles via Google Scholar Google Scholar Articles by Mentel, T. Articles by Pflüger, H.-J. Search for Related Content PubMed PubMed Citation Articles by Mentel, T. Articles by Pflüger, H.-J.

 Previous Article  |  Next Article 

The Journal of Neuroscience, February 15, 2003, 23(4):1109

BRIEF COMMUNICATION
Central Modulatory Neurons Control Fuel Selection in Flight Muscle of Migratory Locust

Tim Mentel¹, Carsten Duch¹, Heike Stypa², Gerhard Wegener², Uli Müller¹, and Hans-Joachim Pflüger¹

¹ Institute of Biology/Neurobiology, Free University Berlin, 14195 Berlin, Germany, and ² Institute of Zoology, Department of Molecular Physiology, Johannes-Gutenberg University, 55099 Mainz, Germany

Insect flight is one of the most intense and energy-demanding physiological activities. High carbohydrate oxidation rates are necessary for take-off, but, to spare the limited carbohydrate reserves, long-distance flyers, such as locusts, soon switch to lipid as the main fuel. We demonstrate that before a flight, locust muscles are metabolically poised for take-off by the release of octopamine from central modulatory dorsal unpaired median (DUM) neurons, which increases the levels of the potent glycolytic activator fructose 2,6-bisphosphate in flight muscle. Because DUM neurons innervating the flight muscles are active during rest but selectively inhibited during flight, they stimulate carbohydrate catabolism during take-off but tend to decrease muscle glycolysis during prolonged flight. cAMP-dependent protein kinase A is necessary but not sufficient for signal transduction, suggesting parallel control via a calcium-dependent pathway. Locust flight is the first reported instance of a direct and specific involvement of neuronal activity in the control of muscle glycolysis in working muscle during exercise.

Key words: insect; octopamine; metabolism; motor behavior; glycolysis; neuromuscular system; modulation

---

Copyright © 2003 Society for Neuroscience  0270-6474/03/2341109-05$05.00/0

Related articles in J. Neurosci.:

This Week in The Journal

J. Neurosci. 2003 23: 0. [Abstract] [Full Text]  

This article has been cited by other articles:

				B. Brembs, F. Christiansen, H. J. Pfluger, and C. Duch Flight Initiation and Maintenance Deficits in Flies with Genetically Altered Biogenic Amine Levels J. Neurosci., October 10, 2007; 27(41): 11122 - 11131. [Abstract] [Full Text] [PDF]

				G Kamp, H Schmidt, H Stypa, S Feiden, C Mahling, and G Wegener Regulatory properties of 6-phosphofructokinase and control of glycolysis in boar spermatozoa Reproduction, January 1, 2007; 133(1): 29 - 40. [Abstract] [Full Text] [PDF]

				D. Wicher, H.-J. Agricola, S. Sohler, M. Gundel, S. H. Heinemann, L. Wollweber, M. Stengl, and C. Derst Differential Receptor Activation by Cockroach Adipokinetic Hormones Produces Differential Effects on Ion Currents, Neuronal Activity, and Locomotion J Neurophysiol, April 1, 2006; 95(4): 2314 - 2325. [Abstract] [Full Text] [PDF]

				D. Bucher CARBS OR FAT? NERVE CELLS THAT CONTROL GLYCOLYSIS IN LOCUST FLIGHT MUSCLES J. Exp. Biol., July 1, 2003; 206(13): 2094 - 2094. [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help