 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, February 15, 2003, 23(4):1517
Time-Dependent Relationship between the Dorsal Hippocampus and the Prefrontal Cortex in Spatial Memory
Inah Lee1 and Raymond P. Kesner2 1 Departments of Neurobiology and Anatomy, University of Texas Houston Medical School, Houston, Texas 77025, and 2 Department of Psychology, University of Utah, Salt Lake City, Utah 84112
The prefrontal cortex and the dorsal hippocampus have been studied extensively for their significant roles in spatial working memory. A possible time-dependent functional relationship between the prefrontal cortex and the dorsal hippocampus in spatial working memory was tested. A combined lesion and pharmacological inactivation technique targeting both the dorsal hippocampus and the medial prefrontal cortex was used (i.e., axon-sparing lesions of the dorsal hippocampus combined with reversible inactivation of the medial prefrontal cortex, or vice versa, within a subject). A delayed nonmatching-to-place task on a radial eight-arm maze with short-term (i.e., 10 sec) versus intermediate-term (i.e., 5 min) delays was used as a behavioral paradigm. Here we report that the dorsal hippocampus and the medial prefrontal cortex process short-term spatial memory in parallel, serving as a compensatory mechanism for each other. The role of the dorsal hippocampus, however, becomes highlighted as the time-window for memory (i.e., delay) shifts from short-term to a delay period (i.e., intermediate-term) exceeding the short-term range. The results indicate that the time window of memory is a key factor in dissociating multiple memory systems.
Key words: dorsal hippocampus; medial prefrontal cortex; spatial working memory; ibotenic acid; quinolinic acid; short-term memory; intermediate-term memory
Copyright © 2003 Society for Neuroscience 0270-6474/03/2341517-07$05.00/0
This article has been cited by other articles:
G. Suzuki, K. M. Harper, T. Hiramoto, B. Funke, M. Lee, G. Kang, M. Buell, M. A. Geyer, R. Kucherlapati, B. Morrow, et al.
Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice
Hum. Mol. Genet., October 15, 2009; 18(20): 3914 - 3925.
[Abstract] [Full Text] [PDF]
T. E. Bjorness, C. L. Kelly, T. Gao, V. Poffenberger, and R. W. Greene
Control and Function of the Homeostatic Sleep Response by Adenosine A1 Receptors
J. Neurosci., February 4, 2009; 29(5): 1267 - 1276.
[Abstract] [Full Text] [PDF]
I. Lee and F. Solivan
The roles of the medial prefrontal cortex and hippocampus in a spatial paired-association task
Learn. Mem., May 5, 2008; 15(5): 357 - 367.
[Abstract] [Full Text] [PDF]
J. J. Chrobak, J. R. Hinman, and H. R. Sabolek
Revealing Past Memories: Proactive Interference and Ketamine-Induced Memory Deficits
J. Neurosci., April 23, 2008; 28(17): 4512 - 4520.
[Abstract] [Full Text] [PDF]
T. Yoon, J. Okada, M. W. Jung, and J. J. Kim
Prefrontal cortex and hippocampus subserve different components of working memory in rats
Learn. Mem., February 19, 2008; 15(3): 97 - 105.
[Abstract] [Full Text] [PDF]
Y. S. Jo, E. H. Park, I. H. Kim, S. K. Park, H. Kim, H. T. Kim, and J.-S. Choi
The Medial Prefrontal Cortex Is Involved in Spatial Memory Retrieval under Partial-Cue Conditions
J. Neurosci., December 5, 2007; 27(49): 13567 - 13578.
[Abstract] [Full Text] [PDF]
W. Li, Y. Zhou, J. D. Jentsch, R. A. M. Brown, X. Tian, D. Ehninger, W. Hennah, L. Peltonen, J. Lonnqvist, M. O. Huttunen, et al.
Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice
PNAS, November 13, 2007; 104(46): 18280 - 18285.
[Abstract] [Full Text] [PDF]
T. Wolbers, J. M. Wiener, H. A. Mallot, and C. Buchel
Differential Recruitment of the Hippocampus, Medial Prefrontal Cortex, and the Human Motion Complex during Path Integration in Humans
J. Neurosci., August 29, 2007; 27(35): 9408 - 9416.
[Abstract] [Full Text] [PDF]
M. D. Saxe, G. Malleret, S. Vronskaya, I. Mendez, A. D. Garcia, M. V. Sofroniew, E. R. Kandel, and R. Hen
Paradoxical influence of hippocampal neurogenesis on working memory
PNAS, March 13, 2007; 104(11): 4642 - 4646.
[Abstract] [Full Text] [PDF]
J. J. Cerqueira, J. M. Pego, R. Taipa, J. M. Bessa, O. F. X. Almeida, and N. Sousa
Morphological Correlates of Corticosteroid-Induced Changes in Prefrontal Cortex-Dependent Behaviors
J. Neurosci., August 24, 2005; 25(34): 7792 - 7800.
[Abstract] [Full Text] [PDF]
R. J. Kyd and D. K. Bilkey
Hippocampal Place Cells Show Increased Sensitivity to Changes in the Local Environment Following Prefrontal Cortex Lesions
Cereb Cortex, June 1, 2005; 15(6): 720 - 731.
[Abstract] [Full Text] [PDF]
M. Wietrzych, H. Meziane, A. Sutter, N. Ghyselinck, P. F. Chapman, P. Chambon, and W. Krezel
Working memory deficits in retinoid X receptor {gamma}-deficient mice
Learn. Mem., May 1, 2005; 12(3): 318 - 326.
[Abstract] [Full Text] [PDF]
M. A. Burman and J. C. Gewirtz
Timing of Fear Expression in Trace and Delay Conditioning Measured by Fear-Potentiated Startle in Rats
Learn. Mem., March 1, 2004; 11(2): 205 - 212.
[Abstract] [Full Text] [PDF]
B. Roozendaal, J. R. McReynolds, and J. L. McGaugh
The Basolateral Amygdala Interacts with the Medial Prefrontal Cortex in Regulating Glucocorticoid Effects on Working Memory Impairment
J. Neurosci., February 11, 2004; 24(6): 1385 - 1392.
[Abstract] [Full Text] [PDF]
M.-C. Buhot, M. Wolff, N. Benhassine, P. Costet, R. Hen, and L. Segu
Spatial Learning in the 5-HT1B Receptor Knockout Mouse: Selective Facilitation/Impairment Depending on the Cognitive Demand
Learn. Mem., November 1, 2003; 10(6): 466 - 477.
[Abstract] [Full Text] [PDF]
M. Wolff, N. Benhassine, P. Costet, R. Hen, L. Segu, and M.-C. Buhot
Delay-Dependent Working Memory Impairment in Young-Adult and Aged 5-HT1BKO Mice as Assessed in a Radial-Arm Water Maze
Learn. Mem., September 1, 2003; 10(5): 401 - 409.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|