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The Journal of Neuroscience, March 1, 2003, 23(5):1622
Dopamine Modulation of Perisomatic and Peridendritic Inhibition in Prefrontal Cortex
Wen-Jun Gao, Yun Wang, and Patricia S. Goldman-Rakic Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510
The computations underlying cognitive functions are performed by a diversity of interactions between interneurons and pyramidal neurons that are subject to modulatory influences. Here we have used paired whole-cell recording to study the influence of dopamine on local inhibitory circuits involving fast-spiking (FS) and non-FS cells, respectively. We found that dopamine depressed inhibitory transmission between FS interneurons and pyramidal neurons but enhanced inhibition between non-FS interneurons and pyramidal cells. FS inhibitory transmission exhibited properties associated with presynaptic action at D1 receptors that were not evident in non-FS inhibitory connections. In addition, FS and non-FS interneurons differed morphologically, forming contacts on the perisomatic and peridendritic domains, respectively, of their pyramidal cell targets. These findings provide evidence for both a dual mode of inhibition in prefrontal circuitry and circuit-dependent modulation by dopamine.
Key words: dual whole-cell recording; GABA; local circuits; interneurons; dopamine; cortical slice
Copyright © 2003 Society for Neuroscience 0270-6474/03/2351622-09$05.00/0
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