QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (69) Citing Articles via Google Scholar Google Scholar Articles by Chojnacki, A. Articles by Weiss, S. Search for Related Content PubMed PubMed Citation Articles by Chojnacki, A. Articles by Weiss, S.

 Previous Article  |  Next Article 

The Journal of Neuroscience, March 1, 2003, 23(5):1730

Glycoprotein 130 Signaling Regulates Notch1 Expression and Activation in the Self-Renewal of Mammalian Forebrain Neural Stem Cells

Andrew Chojnacki¹, Takuya Shimazaki¹, Christopher Gregg¹, Gerry Weinmaster², and Samuel Weiss¹

¹ Genes & Development Research Group, Department of Cell Biology and Anatomy, University of Calgary, Faculty of Medicine, Calgary, Alberta, Canada T2N 4N1, and ² Department of Biological Chemistry, Molecular Biology Institute, University of California at Los Angeles School of Medicine, Los Angeles, California 90095-1737

Glycoprotein130 (gp130) and Notch signaling are thought to participate in neural stem cell (NSC) self-renewal. We asked whether gp130 regulates Notch activity in forebrain epidermal growth factor (EGF)-responsive NSCs. Disruption of Notch1 using antisense or a -secretase inhibitor demonstrated a requirement for Notch1 in the maintenance and proliferation of NSCs. Ciliary neurotrophic factor (CNTF) activation of gp130 in NSCs rapidly increased Notch1 expression. NOTCH1 activation, indicated by tumor necrosis factor -converting enzyme (TACE)- and presenilin-mediated processing, also increased. Infusion of EGF+CNTF into adult forebrain lateral ventricles increased periventricular NOTCH1 compared with EGF alone. Neither Hes1 (hairy and enhancer of split) nor Hes5 appeared to mediate gp130-enhanced NOTCH1 signaling that regulates NSC maintenance. This is the first example of a link between gp130 signaling and NOTCH1 in regulating NSC self-renewal.

Key words: notch; gp130; CNTF; stem cell; delta; self-renewal

---

Copyright © 2003 Society for Neuroscience  0270-6474/03/2351730-12$05.00/0

This article has been cited by other articles:

				P. Zhu, R. Hata, F. Cao, F. Gu, Y. Hanakawa, K. Hashimoto, and M. Sakanaka Ramified microglial cells promote astrogliogenesis and maintenance of neural stem cells through activation of Stat3 function FASEB J, November 1, 2008; 22(11): 3866 - 3877. [Abstract] [Full Text] [PDF]

				P. B. Dirks Brain Tumor Stem Cells: Bringing Order to the Chaos of Brain Cancer J. Clin. Oncol., June 10, 2008; 26(17): 2916 - 2924. [Abstract] [Full Text] [PDF]

				P. Yang, S. A. Arnold, A. Habas, M. Hetman, and T. Hagg Ciliary Neurotrophic Factor Mediates Dopamine D2 Receptor-Induced CNS Neurogenesis in Adult Mice J. Neurosci., February 27, 2008; 28(9): 2231 - 2241. [Abstract] [Full Text] [PDF]

				P. B Dirks Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells Phil Trans R Soc B, January 12, 2008; 363(1489): 139 - 152. [Abstract] [Full Text] [PDF]

				J. Chen, A. Zacharek, A. Li, X. Cui, C. Roberts, M. Lu, and M. Chopp Atorvastatin Promotes Presenilin-1 Expression and Notch1 Activity and Increases Neural Progenitor Cell Proliferation After Stroke Stroke, January 1, 2008; 39(1): 220 - 226. [Abstract] [Full Text] [PDF]

				M. Yanagisawa and R. K Yu The expression and functions of glycoconjugates in neural stem cells Glycobiology, July 1, 2007; 17(7): 57R - 74R. [Abstract] [Full Text] [PDF]

				M. Nagao, M. Sugimori, and M. Nakafuku Cross Talk between Notch and Growth Factor/Cytokine Signaling Pathways in Neural Stem Cells Mol. Cell. Biol., June 1, 2007; 27(11): 3982 - 3994. [Abstract] [Full Text] [PDF]

				J. Chen, A. Crabbe, V. Van Duppen, and H. Vankelecom The Notch Signaling System Is Present in the Postnatal Pituitary: Marked Expression and Regulatory Activity in the Newly Discovered Side Population Mol. Endocrinol., December 1, 2006; 20(12): 3293 - 3307. [Abstract] [Full Text] [PDF]

				Y. Ohori, S.-i. Yamamoto, M. Nagao, M. Sugimori, N. Yamamoto, K. Nakamura, and M. Nakafuku Growth Factor Treatment and Genetic Manipulation Stimulate Neurogenesis and Oligodendrogenesis by Endogenous Neural Progenitors in the Injured Adult Spinal Cord. J. Neurosci., November 15, 2006; 26(46): 11948 - 11960. [Abstract] [Full Text] [PDF]

				S. Bauer and P. H. Patterson Leukemia Inhibitory Factor Promotes Neural Stem Cell Self-Renewal in the Adult Brain. J. Neurosci., November 15, 2006; 26(46): 12089 - 12099. [Abstract] [Full Text] [PDF]

				I. Rooman, N. De Medts, L. Baeyens, J. Lardon, S. De Breuck, H. Heimberg, and L. Bouwens Expression of the Notch Signaling Pathway and Effect on Exocrine Cell Proliferation in Adult Rat Pancreas Am. J. Pathol., October 1, 2006; 169(4): 1206 - 1214. [Abstract] [Full Text] [PDF]

				T. Yoshimatsu, D. Kawaguchi, K. Oishi, K. Takeda, S. Akira, N. Masuyama, and Y. Gotoh Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex Development, July 1, 2006; 133(13): 2553 - 2563. [Abstract] [Full Text] [PDF]

				R. J. Felling, M. J. Snyder, M. J. Romanko, R. P. Rothstein, A. N. Ziegler, Z. Yang, M. I. Givogri, E. R. Bongarzone, and S. W. Levison Neural stem/progenitor cells participate in the regenerative response to perinatal hypoxia/ischemia. J. Neurosci., April 19, 2006; 26(16): 4359 - 4369. [Abstract] [Full Text] [PDF]

				L. S. Campos, L. Decker, V. Taylor, and W. Skarnes Notch, Epidermal Growth Factor Receptor, and beta1-Integrin Pathways Are Coordinated in Neural Stem Cells J. Biol. Chem., February 24, 2006; 281(8): 5300 - 5309. [Abstract] [Full Text] [PDF]

				M. Yamaguchi, N. Tonou-Fujimori, A. Komori, R. Maeda, Y. Nojima, H. Li, H. Okamoto, and I. Masai Histone deacetylase 1 regulates retinal neurogenesis in zebrafish by suppressing Wnt and Notch signaling pathways Development, July 1, 2005; 132(13): 3027 - 3043. [Abstract] [Full Text] [PDF]

				V. von Felbert, F. Cordoba, J. Weissenberger, C. Vallan, M. Kato, I. Nakashima, L. R. Braathen, and J. Weis Interleukin-6 Gene Ablation in a Transgenic Mouse Model of Malignant Skin Melanoma Am. J. Pathol., March 1, 2005; 166(3): 831 - 841. [Abstract] [Full Text] [PDF]

				C. Gregg and S. Weiss CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrain Development, February 1, 2005; 132(3): 565 - 578. [Abstract] [Full Text] [PDF]

				E. Enwere, T. Shingo, C. Gregg, H. Fujikawa, S. Ohta, and S. Weiss Aging Results in Reduced Epidermal Growth Factor Receptor Signaling, Diminished Olfactory Neurogenesis, and Deficits in Fine Olfactory Discrimination J. Neurosci., September 22, 2004; 24(38): 8354 - 8365. [Abstract] [Full Text] [PDF]

				Q. Shen, S. K. Goderie, L. Jin, N. Karanth, Y. Sun, N. Abramova, P. Vincent, K. Pumiglia, and S. Temple Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells Science, May 28, 2004; 304(5675): 1338 - 1340. [Abstract] [Full Text] [PDF]

				M. L. Monje, H. Toda, and T. D. Palmer Inflammatory Blockade Restores Adult Hippocampal Neurogenesis Science, December 5, 2003; 302(5651): 1760 - 1765. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help