WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Côté, M.-P.
Right arrow Articles by Gossard, J.-P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Côté, M.-P.
Right arrow Articles by Gossard, J.-P.

 Previous Article  |  Next Article 

The Journal of Neuroscience, March 1, 2003, 23(5):1886

Task-Dependent Presynaptic Inhibition

Marie-Pascale Côté and Jean-Pierre Gossard

Centre de recherche en sciences neurologiques, Département de physiologie, Faculté de Médecine, Université de Montréal, Montréal, Québec, Canada, H3C 3J7

This study compares the level of presynaptic inhibition during two rhythmic movements in the cat: locomotion and scratch. Dorsal rootlets from L6, L7, or S1 segments were cut, and their proximal stumps were recorded during fictive locomotion occurring spontaneously in decerebrate cats and during fictive scratch induced by D-tubocurarine applied on the C1 and C2 segments. Compared with rest, the number of antidromic spikes was increased (by 12%) during locomotion, whereas it was greatly decreased (31%) during scratch, and the amplitude of dorsal root potentials (DRPs), evoked by stimulating a muscle nerve, was slightly decreased (7%) during locomotion but much more so during scratch (53%). When compared with locomotion, the decrease in the number of antidromic spikes (45%) and the decrease in DRP amplitude (43%) during scratch were of similar magnitude. Also, the amplitude of primary afferent depolarization (PAD), recorded with micropipettes in axons (n = 13) of two cats, was found to be significantly reduced (60%) during scratch compared with rest. During both rhythms, there were cyclic oscillations in dorsal root potential the timing of which was linearly related to the timing of rhythmic activity in tibialis anterior. The amplitude of these oscillations was significantly smaller (34%) during locomotion compared with scratch. These results suggest that the reduction in antidromic activity during scratch was attributable to a task-dependent decrease in transmission in PAD pathways and not to underlying potential oscillations related to the central pattern generator. It is concluded that presynaptic inhibition and antidromic discharge may have a more important role in the control of locomotion than scratch.

Key words: presynaptic inhibition; fictive locomotion; fictive scratch; dorsal root potential; spinal cord; motor control

Copyright © 2003 Society for Neuroscience  0270-6474/03/2351886-08$05.00/0


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
K. Seki, S. I. Perlmutter, and E. E. Fetz
Task-Dependent Modulation of Primary Afferent Depolarization in Cervical Spinal Cord of Monkeys Performing an Instructed Delay Task
J Neurophysiol, July 1, 2009; 102(1): 85 - 99.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
G. Courtine, S. J. Harkema, C. J. Dy, Y. P. Gerasimenko, and P. Dyhre-Poulsen
Modulation of multisegmental monosynaptic responses in a variety of leg muscles during walking and running in humans
J. Physiol., August 1, 2007; 582(3): 1125 - 1139.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Lidierth
Local and diffuse mechanisms of primary afferent depolarization and presynaptic inhibition in the rat spinal cord
J. Physiol., October 1, 2006; 576(1): 309 - 327.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
S. Rossignol
Plasticity of connections underlying locomotor recovery after central and/or peripheral lesions in the adult mammals
Phil Trans R Soc B, September 29, 2006; 361(1473): 1647 - 1671.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. J. Gregor, D. W. Smith, and B. I. Prilutsky
Mechanics of Slope Walking in the Cat: Quantification of Muscle Load, Length Change, and Ankle Extensor EMG Patterns
J Neurophysiol, March 1, 2006; 95(3): 1397 - 1409.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. Rossignol, R. Dubuc, and J.-P. Gossard
Dynamic Sensorimotor Interactions in Locomotion
Physiol Rev, January 1, 2006; 86(1): 89 - 154.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. Le Ray, D. Combes, C. Dejean, and D. Cattaert
In Vivo Analysis of Proprioceptive Coding and Its Antidromic Modulation in the Freely Behaving Crayfish
J Neurophysiol, August 1, 2005; 94(2): 1013 - 1027.
[Abstract] [Full Text] [PDF]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-