QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (29) Citing Articles via Google Scholar Google Scholar Articles by Ravary, A. Articles by Gaspar, P. Search for Related Content PubMed PubMed Citation Articles by Ravary, A. Articles by Gaspar, P.

 Previous Article  |  Next Article 

The Journal of Neuroscience, March 15, 2003, 23(6):2228

Adenylate Cyclase 1 as a Key Actor in the Refinement of Retinal Projection Maps

Anne Ravary¹, Aude Muzerelle¹, Denis Hervé³, Vincent Pascoli³, Kim Nguyen Ba-Charvet¹, Jean-Antoine Girault³, Egbert Welker², and Patricia Gaspar¹

¹ Institut National de la Santé et de la Recherche Médicale Unite 106, Institut Federatif de Neurosciences, Hôpital Pitié-Salpêtrière, 75651 Paris, France, ² Institut de Biologie Cellulaire et Morphologie, University of Lausanne, 1005 Lausanne, Switzerland, and ³ Institut National de la Santé et de la Recherche Médicale Unite 536, Institut du Fer à Moulin, 75005 Paris, France

cAMP occupies a strategic position to control neuronal responses to a large variety of developmental cues. We have analyzed the role of calcium-stimulated adenylate cyclase 1 (AC1) in the development of retinal topographic maps. AC1 is expressed in retinal ganglion cells (RGCs) from embryonic day 15 to adulthood with a peak during the first postnatal week. At that time, the other calcium-stimulated AC, AC8, is expressed in the superior colliculus (SC) but not in the RGCs. In mice of the barrelless strain, which carry an inactivating mutation of the AC1 gene, calcium-stimulated AC activity is reduced by 40-60% in the SC and retina. RGC projection maps were analyzed with a variety of anterograde and retrograde tracers. After an initially normal development until postnatal day 3, retinal fibers from the ipsilateral and contralateral eye fail to segregate into eye-specific domains in the lateral geniculate nucleus and the SC. Topographic defects in the fine tuning of the retinotectal and retinogeniculate maps are also observed with abnormalities in the confinement of the retinal axon arbors in the anteroposterior and mediolateral dimensions. This is attributable to the lack of elimination of misplaced axon collaterals and to the maintenance of a transient ipsilateral projection. These results establish an essential role of AC1 in the fine patterning of the retinal map. Calcium-modulated cAMP production in the RGCs could constitute an important link between activity-dependent changes and the anatomical restructuring of the retinal terminal arbors within central targets.

Key words: cAMP; dLGN; superior colliculus; retinal ganglion cells; developmental plasticity; barrelless

---

Copyright © 2003 Society for Neuroscience  0270-6474/03/2362228-11$05.00/0

This article has been cited by other articles:

				N. Masada, A. Ciruela, D. A. MacDougall, and D. M. F. Cooper Distinct Mechanisms of Regulation by Ca2+/Calmodulin of Type 1 and 8 Adenylyl Cyclases Support Their Different Physiological Roles J. Biol. Chem., February 13, 2009; 284(7): 4451 - 4463. [Abstract] [Full Text] [PDF]

				E. Chatzopoulou, A. Miguez, M. Savvaki, G. Levasseur, A. Muzerelle, M.-P. Muriel, O. Goureau, K. Watanabe, L. Goutebroze, P. Gaspar, et al. Structural Requirement of TAG-1 for Retinal Ganglion Cell Axons and Myelin in the Mouse Optic Nerve J. Neurosci., July 23, 2008; 28(30): 7624 - 7636. [Abstract] [Full Text] [PDF]

				T. Iwasato, M. Inan, H. Kanki, R. S. Erzurumlu, S. Itohara, and M. C. Crair Cortical Adenylyl Cyclase 1 Is Required for Thalamocortical Synapse Maturation and Aspects of Layer IV Barrel Development J. Neurosci., June 4, 2008; 28(23): 5931 - 5943. [Abstract] [Full Text] [PDF]

				R. Linden, V. R. Martins, M. A. M. Prado, M. Cammarota, I. Izquierdo, and R. R. Brentani Physiology of the Prion Protein Physiol Rev, April 1, 2008; 88(2): 673 - 728. [Abstract] [Full Text] [PDF]

				D.-J. Zou, A. T. Chesler, C. E. Le Pichon, A. Kuznetsov, X. Pei, E. L. Hwang, and S. Firestein Absence of Adenylyl Cyclase 3 Perturbs Peripheral Olfactory Projections in Mice J. Neurosci., June 20, 2007; 27(25): 6675 - 6683. [Abstract] [Full Text] [PDF]

				T. A. Dunn, C.-T. Wang, M. A. Colicos, M. Zaccolo, L. M. DiPilato, J. Zhang, R. Y. Tsien, and M. B. Feller Imaging of cAMP Levels and Protein Kinase A Activity Reveals That Retinal Waves Drive Oscillations in Second-Messenger Cascades J. Neurosci., December 6, 2006; 26(49): 12807 - 12815. [Abstract] [Full Text] [PDF]

				F. Gheorghita, R. Kraftsik, R. Dubois, and E. Welker Structural Basis for Map Formation in the Thalamocortical Pathway of the Barrelless Mouse J. Neurosci., September 27, 2006; 26(39): 10057 - 10067. [Abstract] [Full Text] [PDF]

				H.-C. Lu, D. A. Butts, P. S. Kaeser, W.-C. She, R. Janz, and M. C. Crair Role of efficient neurotransmitter release in barrel map development. J. Neurosci., March 8, 2006; 26(10): 2692 - 2703. [Abstract] [Full Text] [PDF]

				X. Nicol, A. Muzerelle, J. P. Rio, C. Metin, and P. Gaspar Requirement of Adenylate Cyclase 1 for the Ephrin-A5-Dependent Retraction of Exuberant Retinal Axons J. Neurosci., January 18, 2006; 26(3): 862 - 872. [Abstract] [Full Text] [PDF]

				G. D. Ferguson and D. R. Storm Why Calcium-Stimulated Adenylyl Cyclases? Physiology, October 1, 2004; 19(5): 271 - 276. [Abstract] [Full Text] [PDF]

				S. Naska, M. C. Cenni, E. Menna, and L. Maffei ERK signaling is required for eye-specific retino-geniculate segregation Development, August 1, 2004; 131(15): 3559 - 3570. [Abstract] [Full Text] [PDF]

				Z. Mao, G. Roman, L. Zong, and R. L. Davis Pharmacogenetic rescue in time and space of the rutabaga memory impairment by using Gene-Switch PNAS, January 6, 2004; 101(1): 198 - 203. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help