QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (38) Citing Articles via Google Scholar Google Scholar Articles by Chisum, H. J. Articles by Fitzpatrick, D. Search for Related Content PubMed PubMed Citation Articles by Chisum, H. J. Articles by Fitzpatrick, D.

 Previous Article  |  Next Article 

The Journal of Neuroscience, April 1, 2003, 23(7):2947

Emergent Properties of Layer 2/3 Neurons Reflect the Collinear Arrangement of Horizontal Connections in Tree Shrew Visual Cortex

Heather J. Chisum, François Mooser, and David Fitzpatrick

Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710

The superficial layers of primary visual cortex, unlike layer 4, have an extensive network of long-range horizontal connections linking sites of similar orientation preference. To identify possible functional consequences of this distinct anatomy, we compared the receptive field properties of layers 2/3 and 4 neurons in tree shrew primary visual cortex with electrophysiological recordings. We found that elongated receptive fields, strong orientation tuning, and length summation (properties predicted by the anatomy of the horizontal connections) are present in layer 2/3 neurons, but not in layer 4 neurons. We further characterized the summation fields of layer 2/3 neurons and found axis and orientation-specific facilitation that matched the distribution of horizontal connections. The functional signature of horizontal connections was also evident in the population response of layer 2/3 neurons; the intrinsic signal activation pattern elicited by an array of collinear Gabor elements was significantly stronger than that elicited by a noncollinear array. Furthermore, our results showed that this enhancement of population response was achieved without compromising spatial resolution along the collinear axis, providing stimulus-specific facilitation without filling in between stimuli. Taken together, these results suggest that horizontal connections play a significant role in shaping the visual responses of layer 2/3 neurons.

Key words: horizontal connections; collinear facilitation; V1; population activity; tree shrew; visual cortex; optical imaging; electrophysiology

---

Copyright © 2003 Society for Neuroscience  0270-6474/03/2372947-14$05.00/0

This article has been cited by other articles:

				Y. B. Sirotin, E. M. C. Hillman, C. Bordier, and A. Das Spatiotemporal precision and hemodynamic mechanism of optical point spreads in alert primates PNAS, October 27, 2009; 106(43): 18390 - 18395. [Abstract] [Full Text] [PDF]

				N. L. Rochefort, P. Buzas, N. Quenech'du, A. Koza, U. T. Eysel, C. Milleret, and Z. F. Kisvarday Functional Selectivity of Interhemispheric Connections in Cat Visual Cortex Cereb Cortex, October 1, 2009; 19(10): 2451 - 2465. [Abstract] [Full Text] [PDF]

				E. Meirovithz, I. Ayzenshtat, Y. S. Bonneh, R. Itzhack, U. Werner-Reiss, and H. Slovin Population Response to Contextual Influences in the Primary Visual Cortex Cereb Cortex, September 16, 2009; (2009) bhp191v1. [Abstract] [Full Text] [PDF]

				J. N. J. McManus, S. Ullman, and C. D. Gilbert A Computational Model of Perceptual Fill-in Following Retinal Degeneration J Neurophysiol, May 1, 2008; 99(5): 2086 - 2100. [Abstract] [Full Text] [PDF]

				A. Grabska-Barwinska and C. von der Malsburg Establishment of a Scaffold for Orientation Maps in Primary Visual Cortex of Higher Mammals J. Neurosci., January 2, 2008; 28(1): 249 - 257. [Abstract] [Full Text] [PDF]

				S. D. Van Hooser Similarity and Diversity in Visual Cortex: Is There a Unifying Theory of Cortical Computation? Neuroscientist, December 1, 2007; 13(6): 639 - 656. [Abstract] [PDF]

				J. M. Ichida, L. Schwabe, P. C. Bressloff, and A. Angelucci Response Facilitation From the "Suppressive" Receptive Field Surround of Macaque V1 Neurons J Neurophysiol, October 1, 2007; 98(4): 2168 - 2181. [Abstract] [Full Text] [PDF]

				T. R. Tucker and D. Fitzpatrick Luminance-Evoked Inhibition in Primary Visual Cortex: A Transient Veto of Simultaneous and Ongoing Response J. Neurosci., December 27, 2006; 26(52): 13537 - 13547. [Abstract] [Full Text] [PDF]

				L. Schwabe, K. Obermayer, A. Angelucci, and P. C. Bressloff The Role of Feedback in Shaping the Extra-Classical Receptive Field of Cortical Neurons: A Recurrent Network Model J. Neurosci., September 6, 2006; 26(36): 9117 - 9129. [Abstract] [Full Text] [PDF]

				S. D. Van Hooser, J. A. Heimel, S. Chung, and S. B. Nelson Lack of patchy horizontal connectivity in primary visual cortex of a mammal without orientation maps. J. Neurosci., July 19, 2006; 26(29): 7680 - 7692. [Abstract] [Full Text] [PDF]

				J. A. Heimel, S. D. Van Hooser, and S. B. Nelson Laminar Organization of Response Properties in Primary Visual Cortex of the Gray Squirrel (Sciurus carolinensis) J Neurophysiol, November 1, 2005; 94(5): 3538 - 3554. [Abstract] [Full Text] [PDF]

				B. D. Moore IV, H. J. Alitto, and W. M. Usrey Orientation Tuning, But Not Direction Selectivity, Is Invariant to Temporal Frequency in Primary Visual Cortex J Neurophysiol, August 1, 2005; 94(2): 1336 - 1345. [Abstract] [Full Text] [PDF]

				M. Gur, I. Kagan, and D. M. Snodderly Orientation and Direction Selectivity of Neurons in V1 of Alert Monkeys: Functional Relationships and Laminar Distributions Cereb Cortex, August 1, 2005; 15(8): 1207 - 1221. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help