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The Journal of Neuroscience, April 1, 2003, 23(7):3006

On the Transmission of Rate Code in Long Feedforward Networks with Excitatory-Inhibitory Balance

Vladimir Litvak¹, Haim Sompolinsky^{1, 2}, Idan Segev^{1, 3}, and Moshe Abeles^{1, 4}

¹ The Interdisciplinary Center for Neural Computation, ² The Racah Institute of Physics, ³ Department of Neurobiology, Institute of Life Sciences, and ⁴ Department of Physiology, Hadassah Medical School, The Hebrew University, Jerusalem 91904, Israel

The capability of feedforward networks composed of multiple layers of integrate-and-fire neurons to transmit rate code was examined. Synaptic connections were made only from one layer to the next, and excitation was balanced by inhibition. When time is discrete and the synaptic potentials rise instantaneously, we show that, for random uncorrelated input to layer one, the mean rate of activity in deep layers is essentially independent of input firing rate. This implies that the input rate cannot be transmitted reliably in such feedforward networks because neurons in a given layer tend to synchronize partially with each other because of shared inputs. As a result of this synchronization, the average firing rate in deep layers will either decay to zero or reach a stable fixed point, depending on model parameters. When time is treated continuously and the synaptic potentials rise instantaneously, these effects develop slowly, and rate transmission over a limited number of layers is possible. However, the correlations among neurons at the same layer hamper reliable assessment of firing rate by averaging over 100 msec (or less). When the synaptic potentials develop gradually, as is the realistic case, transmission of rate code fails. In a network in which inhibition only balances the mean excitation but is not timed precisely with it, neurons in each layer fire together, and this volley successively propagates from layer to layer. We conclude that the transmission of rate code in feedforward networks is highly unlikely.

Key words: rate code; temporal code; synfire chain; network models; excitation-inhibition balance; synchrony; bistability; correlation; synaptic integration; information transmission

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Copyright © 2003 Society for Neuroscience  0270-6474/03/2373006-10$05.00/0

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