 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, April 1, 2003, 23(7):3052
Temporal Masking Reveals Properties of Sound-Evoked Inhibition in Duration-Tuned Neurons of the Inferior Colliculus
Paul A. Faure, Thane Fremouw, John H. Casseday, and Ellen Covey Department of Psychology, University of Washington, Seattle, Washington 98195-1525
The inferior colliculus (IC) is the first place in the central auditory pathway where duration-selective neurons are found. Previous neuropharmacological and electrophysiological studies have shown that they are created there and have led to a conceptual model in which excitatory and inhibitory inputs are offset in time so that the cell fires only when sound duration is such that onset- and offset-evoked excitation coincide; the response is suppressed by inhibition at other durations. We tested predictions from the model using paired tone stimulation and extracellular recording in the IC of the big brown bat, Eptesicus fuscus. Responses to a best duration (BD) tone were used as a probe to examine the strength and time course of inhibition activated by a nonexcitatory (NE) tone of the same frequency but differing in duration. As the relative time between the BD and NE tones was varied, the activity evoked by the BD tone was affected in ways comparable with backward, simultaneous, and forward masking. Responses to the BD tone were completely suppressed at short interstimulus intervals when the BD tone preceded the NE tone. Suppression was also seen when the stimuli temporally overlapped and summed and at intervals when the BD tone followed the NE tone. The results show that duration-selective neurons receive an onset-evoked, inhibitory input that precedes their excitatory input. The period of leading inhibition was correlated with BD and first spike latency. The results suggest how inhibition in the CNS could explain temporal masking phenomena, including backward masking.
Key words: audition; auditory midbrain; big brown bat (Eptesicus fuscus); duration tuning; echolocation; neural delay lines; neuroethology
Copyright © 2003 Society for Neuroscience 0270-6474/03/2373052-14$05.00/0
This article has been cited by other articles:
B. Aubie, S. Becker, and P. A. Faure
Computational Models of Millisecond Level Duration Tuning in Neural Circuits
J. Neurosci., July 22, 2009; 29(29): 9255 - 9270.
[Abstract] [Full Text] [PDF]
A. Kutscher and E. Covey
Functional Role of GABAergic and Glycinergic Inhibition in the Intermediate Nucleus of the Lateral Lemniscus of the Big Brown Bat
J Neurophysiol, June 1, 2009; 101(6): 3135 - 3146.
[Abstract] [Full Text] [PDF]
M. S. Malmierca, S. Cristaudo, D. Perez-Gonzalez, and E. Covey
Stimulus-Specific Adaptation in the Inferior Colliculus of the Anesthetized Rat
J. Neurosci., April 29, 2009; 29(17): 5483 - 5493.
[Abstract] [Full Text] [PDF]
P. C. Nelson, Z. M. Smith, and E. D. Young
Wide-Dynamic-Range Forward Suppression in Marmoset Inferior Colliculus Neurons Is Generated Centrally and Accounts for Perceptual Masking
J. Neurosci., February 25, 2009; 29(8): 2553 - 2562.
[Abstract] [Full Text] [PDF]
C. J. Leary, C. J. Edwards, and G. J. Rose
Midbrain Auditory Neurons Integrate Excitation and Inhibition to Generate Duration Selectivity: An In Vivo Whole-Cell Patch Study in Anurans
J. Neurosci., May 21, 2008; 28(21): 5481 - 5493.
[Abstract] [Full Text] [PDF]
F. Luo, W. Metzner, F. J. Wu, S. Y. Zhang, and Q. C. Chen
Duration-Sensitive Neurons in the Inferior Colliculus of Horseshoe Bats: Adaptations for Using CF-FM Echolocation Pulses
J Neurophysiol, January 1, 2008; 99(1): 284 - 296.
[Abstract] [Full Text] [PDF]
Q. Yue, J. H. Casseday, and E. Covey
Response Properties and Location of Neurons Selective for Sinusoidal Frequency Modulations in the Inferior Colliculus of the Big Brown Bat
J Neurophysiol, September 1, 2007; 98(3): 1364 - 1373.
[Abstract] [Full Text] [PDF]
S. V. Voytenko and A. V. Galazyuk
Intracellular Recording Reveals Temporal Integration in Inferior Colliculus Neurons of Awake Bats
J Neurophysiol, February 1, 2007; 97(2): 1368 - 1378.
[Abstract] [Full Text] [PDF]
Z. M. Fuzessery, M. D. Richardson, and M. S. Coburn
Neural Mechanisms Underlying Selectivity for the Rate and Direction of Frequency-Modulated Sweeps in the Inferior Colliculus of the Pallid Bat
J Neurophysiol, September 1, 2006; 96(3): 1320 - 1336.
[Abstract] [Full Text] [PDF]
A. Kadner, R. J. Kulesza Jr, and A. S. Berrebi
Neurons in the Medial Nucleus of the Trapezoid Body and Superior Paraolivary Nucleus of the Rat May Play a Role in Sound Duration Coding
J Neurophysiol, March 1, 2006; 95(3): 1499 - 1508.
[Abstract] [Full Text] [PDF]
D. Perez-Gonzalez, M. S. Malmierca, J. M. Moore, O. Hernandez, and E. Covey
Duration Selective Neurons in the Inferior Colliculus of the Rat: Topographic Distribution and Relation of Duration Sensitivity to Other Response Properties
J Neurophysiol, February 1, 2006; 95(2): 823 - 836.
[Abstract] [Full Text] [PDF]
R. Xie, J. Meitzen, and G. D. Pollak
Differing Roles of Inhibition in Hierarchical Processing of Species-Specific Calls in Auditory Brainstem Nuclei
J Neurophysiol, December 1, 2005; 94(6): 4019 - 4037.
[Abstract] [Full Text] [PDF]
J. Zhang, K. T. Nakamoto, and L. M. Kitzes
Modulation of Level Response Areas and Stimulus Selectivity of Neurons in Cat Primary Auditory Cortex
J Neurophysiol, October 1, 2005; 94(4): 2263 - 2274.
[Abstract] [Full Text] [PDF]
T. Fremouw, P. A. Faure, J. H. Casseday, and E. Covey
Duration Selectivity of Neurons in the Inferior Colliculus of the Big Brown Bat: Tolerance to Changes in Sound Level
J Neurophysiol, September 1, 2005; 94(3): 1869 - 1878.
[Abstract] [Full Text] [PDF]
L. M. Hurley and G. D. Pollak
Serotonin Shifts First-Spike Latencies of Inferior Colliculus Neurons
J. Neurosci., August 24, 2005; 25(34): 7876 - 7886.
[Abstract] [Full Text] [PDF]
A. V. Galazyuk, W. Lin, D. Llano, and A. S. Feng
Leading Inhibition to Neural Oscillation Is Important for Time-Domain Processing in the Auditory Midbrain
J Neurophysiol, July 1, 2005; 94(1): 314 - 326.
[Abstract] [Full Text] [PDF]
P. O. Kanold and P. B. Manis
Encoding the Timing of Inhibitory Inputs
J Neurophysiol, May 1, 2005; 93(5): 2887 - 2897.
[Abstract] [Full Text] [PDF]
F.-G. Zeng, K. Nie, G. S. Stickney, Y.-Y. Kong, M. Vongphoe, A. Bhargave, C. Wei, and K. Cao
Speech recognition with amplitude and frequency modulations
PNAS, February 15, 2005; 102(7): 2293 - 2298.
[Abstract] [Full Text] [PDF]
A. G. Paolini, J. C. Clarey, K. Needham, and G. M. Clark
Fast Inhibition Alters First Spike Timing in Auditory Brainstem Neurons
J Neurophysiol, October 1, 2004; 92(4): 2615 - 2621.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|