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The Journal of Neuroscience, April 1, 2003, 23(7):3085
Circadian and Photic Regulation of Phosphorylation of ERK1/2 and
Elk-1 in the Suprachiasmatic Nuclei of the Syrian Hamster
Andrew N.
Coogan and
Hugh D.
Piggins
School of Biological Sciences, University of Manchester,
Manchester, United Kingdom M13 9PT
In this study we investigated the circadian and photic regulation
of phosphorylation of the extracellular signal-related kinase (ERK) 1/2, and the transcription factor Elk-1 in the
suprachiasmatic nuclei of the Syrian hamster. We report that levels of
phosphorylated ERK (P-ERK) are rhythmic, peaking during the mid
subjective day, whereas phosphorylated Elk-1 (P-Elk-1) shows no
distinct rhythm. Light pulses during the subjective night rapidly, but
transiently, induce P-ERK, whereas P-Elk-1 is also induced, albeit with
a slower time course. Application of the ERK pathway inhibitor U0126
attenuates photic induction of both P-ERK and P-Elk-1 and phase
advances of wheel-running behavior. The NMDA receptor channel
blocker, MK-801, also significantly attenuates photic induction of
P-ERK and P-Elk-1. Taken together, these results indicate a role of the
ERK cascade in the regulation of free-running circadian rhythms and of
photic-resetting of these rhythms and suggest that in the mammalian
suprachiasmatic nuclei, Elk-1 represents a novel molecular component of
the photic-induction pathway.
Key words:
circadian; MAP kinase; clocks; brain; phosphorylation; Elk-1
Copyright © 2003 Society for Neuroscience 0270-6474/03/2373085-09$05.00/0
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