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The Journal of Neuroscience, April 15, 2003, 23(8):3118

BRIEF COMMUNICATION
Small GTPase Cdc42 Is Required for Multiple Aspects of Dendritic Morphogenesis

Ethan K. Scott, John E. Reuter, and Liqun Luo

Department of Biological Sciences, Stanford University, Stanford, California 94305-5020

The study of dendritic development in CNS neurons has been hampered by a lack of complex dendritic structures that can be studied in a tractable genetic system. In an effort to develop such a system, we recently characterized the highly complex dendrites of the vertical system (VS) neurons in the Drosophila visual system. Using VS neurons as a model system, we show here using loss-of-function mutations that endogenous Cdc42, a member of Rho family of small GTPases, is required for multiple aspects of dendritic morphogenesis. Cdc42-mutant VS neurons display normal complexity but increased dendritic length compared with wild type and have defects in dendrite caliber and stereotyped dendritic branch positions. Remarkably, Cdc42 mutant neurons also show a 50% reduction in dendritic spine density. These results demonstrate that Cdc42 is a regulator for multiple aspects of dendritic development.

Key words: Drosophila; vertical system; dendrites; dendritic spines; Rho GTPases; actin cytoskeleton

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Copyright © 2003 Society for Neuroscience  0270-6474/03/2383118-06$05.00/0

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