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The Journal of Neuroscience, April 15, 2003, 23(8):3243

Normalization of Ca²⁺ Signals by Small Oblique Dendrites of CA1 Pyramidal Neurons

Andreas Frick^{1, 3}, Jeffrey Magee^{2, 3}, Helmut J. Koester^{1, 3}, Michele Migliore⁴, and Daniel Johnston^{1, 3}

¹ Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, ² Neuroscience Center, Louisiana State University Health Science Center, New Orleans, Louisiana 70112, ³ Marine Biological Laboratory, Woods Hole, Massachusetts 02543, and ⁴ Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8001

Oblique dendrites of CA1 pyramidal neurons predominate in stratum radiatum and receive ~80% of the synaptic input from Schaffer collaterals. Despite this fact, most of our understanding of dendritic signal processing in these neurons comes from studies of the main apical dendrite. Using a combination of Ca²⁺ imaging and whole-cell recording techniques in rat hippocampal slices, we found that the properties of the oblique dendrites differ markedly from those of the main dendrites. These different properties tend to equalize the Ca²⁺ rise from single action potentials as they backpropagate into the oblique dendrites from the main trunk. Evidence suggests that this normalization of Ca²⁺ signals results from a higher density of a transient, A-type K⁺ current [I_K(A)] in the oblique versus the main dendrites. The higher density of I_K(A) may have important implications for our understanding of synaptic integration and plasticity in these structures.

Key words: oblique dendrites; pyramidal neurons; hippocampus; two-photon microscopy; Ca²⁺ imaging; backpropagating action potentials; 4-AP-sensitive K⁺ channels

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Copyright © 2003 Society for Neuroscience  0270-6474/03/2383243-08$05.00/0

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