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The Journal of Neuroscience, April 15, 2003, 23(8):3415

Inhibition of Conditioned Stimulus Pathway Phosphoprotein 24 Expression Blocks the Development of Intermediate-Term Memory in Hermissenda

Terry Crow¹, John B. Redell², Lian-Ming Tian¹, Juan Xue-Bian¹, and Pramod K. Dash^{1, 2}

¹ Department of Neurobiology and Anatomy, ² Vivian L. Smith Center for Neurologic Research, University of Texas Medical School, Houston, Texas 77225

Studies of memory consolidation have identified multiple phases or stages in the formation of memories. The multiple components of memory can be broadly divided into the three phases; short-term, intermediate-term, and long-term. Although molecular changes underlying short- and long-term memory have been examined extensively, the molecular mechanisms supporting the formation of intermediate-term memory are poorly understood. In several examples of cellular and synaptic plasticity, intermediate memory depends on translation but not transcription. One-trial conditioning in Hermissenda results in the development of intermediate memory that is associated with enhanced cellular excitability and the phosphorylation of a 24 kDa protein referred to as conditioned stimulus pathway phosphoprotein (Csp24). Using amino acid sequences derived from Csp24 peptide fragments, a full-length cDNA was cloned and shown to contain multiple -thymosin-like domains. The expression of Csp24 and the development of enhanced excitability, a characteristic of intermediate memory, were blocked by antisense oligonucleotide-mediated downregulation of Csp24 without affecting the induction of immediate enhanced excitability, a characteristic of short-term memory. These results demonstrate that the synthesis of Csp24 is required for the development and maintenance of intermediate memory.

Key words: Hermissenda; Csp24; -thymosin repeat protein; one-trial Pavlovian conditioning; actin-binding proteins; cytoskeleton

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Copyright © 2003 Society for Neuroscience  0270-6474/03/2383415-08$05.00/0

This article has been cited by other articles:

				T. CROW and J.-J. XUE-BIAN One-Trial In Vitro Conditioning of Hermissenda Regulates Phosphorylation of Ser-122 of Csp24 Ann. N.Y. Acad. Sci., September 1, 2007; 1112(1): 189 - 200. [Abstract] [Full Text] [PDF]

				E. N. Yamoah, S. Levic, J. B. Redell, and T. Crow Inhibition of Conditioned Stimulus Pathway Phosphoprotein 24 Expression Blocks the Reduction in A-Type Transient K+ Current Produced by One-Trial In Vitro Conditioning of Hermissenda J. Neurosci., May 11, 2005; 25(19): 4793 - 4800. [Abstract] [Full Text] [PDF]

				K. Parvez, O. Stewart, S. Sangha, and K. Lukowiak Boosting intermediate-term into long-term memory J. Exp. Biol., April 15, 2005; 208(8): 1525 - 1536. [Abstract] [Full Text] [PDF]

				T. Crow Pavlovian Conditioning of Hermissenda: Current Cellular, Molecular, and Circuit Perspectives Learn. Mem., May 1, 2004; 11(3): 229 - 238. [Abstract] [Full Text] [PDF]

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