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The Journal of Neuroscience, April 15, 2003, 23(8):3432

Reappraisal of the Motor Role of Basal Ganglia: A Functional Magnetic Resonance Image Study

Takayuki Taniwaki^{1, *}, Akira Okayama^{1, 2, *}, Takashi Yoshiura³, Yasuhiko Nakamura³, Yoshinobu Goto¹, Jun-ichi Kira², and Shozo Tobimatsu¹

Departments of ¹ Clinical Neurophysiology, ² Neurology, and ³ Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan

The importance of the basal ganglia in controlling motor function is well known. However, neuroimaging studies have failed to show either movement-rate dependence or different activation patterns caused by self-initiated (SI) and externally triggered (ET) movements in the basal ganglia-thalamo-motor loop. We herein report the functional magnetic resonance image (fMRI) mapping of sequential left-hand finger movements at five different rates under SI and ET conditions. Significant movement-rate dependence was found in the whole right basal ganglia-thalamo-motor loop only during the SI task. Network analysis also showed strong interactions within this loop during SI movement, whereas interactions were present only from the premotor cortex to the putamen via the sensorimotor cortex during the ET task. Furthermore, psychophysiological interaction analysis confirmed the different modulation between the two tasks in the putamen. fMRI provides evidence that the basal ganglia-thalamo-motor loop plays a key role in controlling the rate of sequential finger movements in SI movement but not in ET movement.

Key words: basal ganglia; fMRI; motor control; self-initiated movement; externally triggered movement; movement rate; path analysis

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^* T.T. and A.O. contributed equally to this work.

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Copyright © 2003 Society for Neuroscience  0270-6474/03/2383432-07$05.00/0

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