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The Journal of Neuroscience, May 1, 2003, 23(9):3908

Estrogen Modulates the Visceromotor Reflex and Responses of Spinal Dorsal Horn Neurons to Colorectal Stimulation in the Rat

Yaping Ji^{1, 4}, Anne Z. Murphy^{2, 3, 4}, and Richard J. Traub^{1, 2, 3, 4}

Departments of ¹ Oral and Craniofacial Biological Sciences, Dental School and ² Anatomy and Neurobiology, Medical School, ³ Program in Neuroscience, and ⁴ Research Center for Neuroendocrine Influences on Pain, University of Maryland, Baltimore, Maryland 21201

Many gastrointestinal pain syndromes are more prevalent in women than men, suggesting a gonadal steroid influence. We characterized the effects of estrogen on two responses to colorectal distention (CRD) in the rat: the visceromotor reflex (vmr) and L6-S1 dorsal horn neuron activity (ABRUPT and SUSTAINED neurons). Ovariectomized rats were injected with estrogen, and responses to innocuous and noxious intensities of CRD were measured between 4 hr and 14 d after injection and compared with ovariectomized and intact, cycling rats. Plasma estrogen levels were determined at each time point. Ovariectomy significantly decreased the magnitude of the vmr and ABRUPT neuron response to CRD compared with cycling rats. Four and 48 hr after estrogen injection (10 µg), the magnitude of the vmr and ABRUPT neuron response returned to the level or greater than that of cycling rats. All responses were comparable with ovariectomized rats by 7 d. These results paralleled the plasma estrogen concentration. Fifty micrograms of estrogen did not further increase the magnitude of the vmr or neuronal response 48 hr after estrogen but did extend the period of the increased ABRUPT neuron response to 14 d. Estrogen did not affect the response of SUSTAINED neurons. In a separate experiment, the response to innocuous CRD was sensitized in estrogen-treated rats but not ovariectomized or cycling rats. The present data suggest that estrogen modulates the spinal cord processing and reflex responses to innocuous and noxious colorectal stimuli in female rats and may contribute to alterations in sensory processing associated with irritable bowel syndrome.

Key words: visceral pain; visceral hyperalgesia; gonadal steroids; nociception; estrogen; lumbosacral spinal cord; electrophysiology; irritable bowel syndrome; IBS

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Copyright © 2003 Society for Neuroscience  0270-6474/03/2393908-08$05.00/0

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