QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, January 7, 2004, 24(1):85-95; doi:10.1523/JNEUROSCI.1574-03.2004

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (58) Citing Articles via Google Scholar Google Scholar Articles by Moreno-López, B. Articles by Estrada, C. Search for Related Content PubMed PubMed Citation Articles by Moreno-López, B. Articles by Estrada, C.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Nitric Oxide Is a Physiological Inhibitor of Neurogenesis in the Adult Mouse Subventricular Zone and Olfactory Bulb

Bernardo Moreno-López, Carmen Romero-Grimaldi, José Angel Noval, Maribel Murillo-Carretero, Esperanza R. Matarredona, and Carmen Estrada

Área de Fisiología, Facultad de Medicina, Universidad de Cádiz, 11003 Cádiz, Spain

The subventricular zone of the rodent brain retains the capacity of generating new neurons in adulthood. The newly formed neuroblasts migrate rostrally toward the olfactory bulb, where they differentiate as granular and periglomerular interneurons. The reported presence of differentiated neurons expressing the neuronal isoform of nitric oxide synthase (NOS) in the periphery of the neurogenic region and the organization of their varicose axons as a network in which the precursors are immersed raised the hypothesis that endogenous nitric oxide (NO) may participate in the control of neurogenesis in the subventricular zone. Systemic administration of the NOS inhibitors N-nitro-L-arginine methyl ester or 7-nitroindazole to adult mice produced a dose- and time-dependent increase in the number of mitotic cells in the subventricular zone, rostral migratory stream, and olfactory bulb, but not in the dentate gyrus of the hippocampus, without affecting apoptosis. In the subventricular zone, this effect was exerted selectively on a precursor subpopulation expressing nestin but not neuronal or glial cell-specific proteins. In addition, in the olfactory bulb, analysis of maturation markers in the newly generated neurons indicated that chronic NOS inhibition caused a delay in neuronal differentiation. Postmitotic cell survival and migration were not affected when NO production was impaired. Our results suggest that NO, produced by nitrergic neurons in the adult mouse subventricular zone and olfactory bulb, exerts a negative control on the size of the undifferentiated precursor pool and promotes neuronal differentiation.

Key words: adult neurogenesis; neural phenotypes; neural precursor proliferation; neuroblasts; nitric oxide synthase; olfactory bulb; subventricular zone

---

Received June 24, 2003; revised September 22, 2003; accepted October 10, 2003.

This article has been cited by other articles:

				L. G. Rabaneda, M. Carrasco, M. A. Lopez-Toledano, M. Murillo-Carretero, F. A. Ruiz, C. Estrada, and C. Castro Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1/2-dependent cyclin E expression FASEB J, November 1, 2008; 22(11): 3823 - 3835. [Abstract] [Full Text] [PDF]

				D. Gonzalez-Forero, F. Portillo, L. Gomez, F. Montero, S. Kasparov, and B. Moreno-Lopez Inhibition of Resting Potassium Conductances by Long-Term Activation of the NO/cGMP/Protein Kinase G Pathway: A New Mechanism Regulating Neuronal Excitability J. Neurosci., June 6, 2007; 27(23): 6302 - 6312. [Abstract] [Full Text] [PDF]

				A. Torroglosa, M. Murillo-Carretero, C. Romero-Grimaldi, E. R. Matarredona, A. Campos-Caro, and C. Estrada Nitric Oxide Decreases Subventricular Zone Stem Cell Proliferation by Inhibition of Epidermal Growth Factor Receptor and Phosphoinositide-3-Kinase/Akt Pathway Stem Cells, January 1, 2007; 25(1): 88 - 97. [Abstract] [Full Text] [PDF]

				R. Covacu, A. I. Danilov, B. S. Rasmussen, K. Hallen, M. C. Moe, A. Lobell, C. B. Johansson, M. A. Svensson, T. Olsson, and L. Brundin Nitric Oxide Exposure Diverts Neural Stem Cell Fate from Neurogenesis Towards Astrogliogenesis Stem Cells, December 1, 2006; 24(12): 2792 - 2800. [Abstract] [Full Text] [PDF]

				S. H. Kim, S. J. Won, X. O. Mao, C. Ledent, K. Jin, and D. A. Greenberg Role for Neuronal Nitric-Oxide Synthase in Cannabinoid-Induced Neurogenesis J. Pharmacol. Exp. Ther., October 1, 2006; 319(1): 150 - 154. [Abstract] [Full Text] [PDF]

				E. Ciani, V. Calvanese, C. Crochemore, R. Bartesaghi, and A. Contestabile Proliferation of cerebellar precursor cells is negatively regulated by nitric oxide in newborn rat J. Cell Sci., August 1, 2006; 119(15): 3161 - 3170. [Abstract] [Full Text] [PDF]

				D. J. Gifondorwa and E. M. Leise Programmed Cell Death in the Apical Ganglion During Larval Metamorphosis of the Marine Mollusc Ilyanassa obsoleta Biol. Bull., April 1, 2006; 210(2): 109 - 120. [Abstract] [Full Text] [PDF]

				R. L. Zhang, Z. G. Zhang, and M. Chopp Neurogenesis in the Adult Ischemic Brain: Generation, Migration, Survival, and Restorative Therapy Neuroscientist, October 1, 2005; 11(5): 408 - 416. [Abstract] [PDF]

				C. Estrada and M. Murillo-Carretero Nitric Oxide and Adult Neurogenesis in Health and Disease Neuroscientist, August 1, 2005; 11(4): 294 - 307. [Abstract] [PDF]

				C. R. Sunico, F. Portillo, D. Gonzalez-Forero, and B. Moreno-Lopez Nitric Oxide-Directed Synaptic Remodeling in the Adult Mammal CNS J. Neurosci., February 9, 2005; 25(6): 1448 - 1458. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help