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The Journal of Neuroscience, March 17, 2004, 24(11):2602-2611; doi:10.1523/JNEUROSCI.5192-03.2004

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Behavioral/Systems/Cognitive
Enantioselectivity of Projection Neurons Innervating Identified Olfactory Glomeruli

Carolina E. Reisenman,¹ Thomas A. Christensen,¹ Wittko Francke,² and John G. Hildebrand¹

¹Arizona Research Laboratories, Division of Neurobiology, University of Arizona, Tucson, Arizona 85721-0077, and ²Institut für Organische Chemie, Universität Hamburg, 20146 Hamburg, Germany

Projection neurons (PNs) with arborizations in the sexually dimorphic "lateral large female glomerulus" (latLFG) in the antennal lobe (AL) of the moth Manduca sexta previously were shown to respond preferentially to antennal stimulation with (±)linalool, a volatile compound commonly emitted by plants. In the present study, using intracellular recording and staining techniques, we examined the responsiveness of latLFG-PNs to the enantiomers, (+)linalool and (–)linalool and found that (1) latLFG-PNs are more responsive to antennal stimulation with (+)linalool than with (–)linalool, (2) PNs with arborizations in a glomerulus adjacent to the latLFG are preferentially responsive to (–)linalool, and (3) PNs with arborizations confined to other glomeruli near the latLFG are equally responsive to both enantiomers of linalool. Structure-activity studies showed that the hydroxyl group in this tertiary terpene alcohol is the key feature of the molecule determining the response of enantioselective PNs to linalool. In contrast, the responses of non-enantioselective PNs are less dependent on the alcoholic functionality of linalool. Our findings show that PNs innervating a uniquely identifiable glomerulus respond preferentially to a particular enantiomer of an odor substance. Moreover, PNs with arborizations in a glomerulus adjacent to the latLFG, although less sensitive than latLFG-PNs to linalool, respond preferentially to the opposite enantiomer, demonstrating that information about stimulus-absolute configuration can be encoded in different olfactory glomeruli.

Key words: olfaction; enantiomers; odor coding; glomerulus; insect; electrophysiology; intracellular recording

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Received Nov 24, 2003; revised January 28, 2004; accepted February 3, 2004.

This article has been cited by other articles:

				C. E. Reisenman, T. Heinbockel, and J. G. Hildebrand Inhibitory Interactions Among Olfactory Glomeruli Do Not Necessarily Reflect Spatial Proximity J Neurophysiol, August 1, 2008; 100(2): 554 - 564. [Abstract] [Full Text] [PDF]

				K. C. Daly, L. A. Carrell, and E. Mwilaria Characterizing Psychophysical Measures of Discrimination Thresholds and the Effects of Concentration on Discrimination Learning in the Moth Manduca sexta Chem Senses, January 1, 2008; 33(1): 95 - 106. [Abstract] [Full Text] [PDF]

				S. Ulland, E. Ian, A.-K. Borg-Karlson, and H. Mustaparta Discrimination between Enantiomers of Linalool by Olfactory Receptor Neurons in the Cabbage Moth Mamestra brassicae (L.) Chem Senses, May 1, 2006; 31(4): 325 - 334. [Abstract] [Full Text] [PDF]

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				I. Masante-Roca, C. Gadenne, and S. Anton Three-dimensional antennal lobe atlas of male and female moths, Lobesia botrana (Lepidoptera: Tortricidae) and glomerular representation of plant volatiles in females J. Exp. Biol., March 15, 2005; 208(6): 1147 - 1159. [Abstract] [Full Text] [PDF]

				T. A. Christensen Making Scents Out of Spatial and Temporal Codes in Specialist and Generalist Olfactory Networks Chem Senses, January 1, 2005; 30(suppl_1): i283 - i284. [Full Text] [PDF]

				H. Lei, T. A. Christensen, and J. G. Hildebrand Spatial and Temporal Organization of Ensemble Representations for Different Odor Classes in the Moth Antennal Lobe J. Neurosci., December 8, 2004; 24(49): 11108 - 11119. [Abstract] [Full Text] [PDF]

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