QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, March 31, 2004, 24(13):3289-3294; doi:10.1523/JNEUROSCI.5338-03.2004

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (22) Citing Articles via Google Scholar Google Scholar Articles by Demarque, M. Articles by Aniksztejn, L. Search for Related Content PubMed PubMed Citation Articles by Demarque, M. Articles by Aniksztejn, L.

 Previous Article  |  Next Article 

BRIEF COMMUNICATION
Glutamate Transporters Prevent the Generation of Seizures in the Developing Rat Neocortex

Michael Demarque, Nathalie Villeneuve, Jean-Bernard Manent, Hélène Becq, Alfonso Represa, Yehezkel Ben-Ari, and Laurent Aniksztejn

Institut de Neurobiologie de la Méditerranée/Institut National de la Santé et de la Recherche Médicale U29, Parc Scientifique de Luminy, 13009 Marseille, France

Glutamate transporters are operative at an early developmental stage well before synapse formation, but their functional significance has not been determined. We now report that blockade of glutamate transporters in the immature neocortex generates recurrent NMDA receptor-mediated currents associated with synchronous oscillations of [Ca²⁺]_i in the entire neuronal population. Intracerebroventricular injections of the blocker to pups generate seizures that are prevented by coinjections of NMDA receptor blockers. Therefore, the early expression of glutamate transporters plays a central role to prevent the activation by local glutamate concentrations of NMDA receptors and the generation of seizures that may alter the construction of cortical networks. A dysfunction of glutamate transporters may be a central event in early infancy epilepsy syndromes.

Key words: cortex; epilepsy; network; synchrony; transport; N-methyl-D-aspartate

---

Received Dec 3, 2003; revised January 12, 2004; accepted January 28, 2004.

This article has been cited by other articles:

				C. Takasaki, R. Okada, A. Mitani, M. Fukaya, M. Yamasaki, Y. Fujihara, T. Shirakawa, K. Tanaka, and M. Watanabe Glutamate Transporters Regulate Lesion-Induced Plasticity in the Developing Somatosensory Cortex J. Neurosci., May 7, 2008; 28(19): 4995 - 5006. [Abstract] [Full Text] [PDF]

				A. A. Cattani, V. D. Bonfardin, A. Represa, Y. Ben-Ari, and L. Aniksztejn Generation of Slow Network Oscillations in the Developing Rat Hippocampus After Blockade of Glutamate Uptake J Neurophysiol, October 1, 2007; 98(4): 2324 - 2336. [Abstract] [Full Text] [PDF]

				Y. Ben-Ari, J.-L. Gaiarsa, R. Tyzio, and R. Khazipov GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations Physiol Rev, October 1, 2007; 87(4): 1215 - 1284. [Abstract] [Full Text] [PDF]

				J.-B. Manent and A. Represa Neurotransmitters and Brain Maturation: Early Paracrine Actions of GABA and Glutamate Modulate Neuronal Migration Neuroscientist, June 1, 2007; 13(3): 268 - 279. [Abstract] [PDF]

				B. Lasztoczi and J. Kardos Cyclothiazide Prolongs Low [Mg2+]-Induced Seizure-Like Events J Neurophysiol, December 1, 2006; 96(6): 3538 - 3544. [Abstract] [Full Text] [PDF]

				E. Sharifullina and A. Nistri Glutamate uptake block triggers deadly rhythmic bursting of neonatal rat hypoglossal motoneurons J. Physiol., April 15, 2006; 572(2): 407 - 423. [Abstract] [Full Text] [PDF]

				W. J. Moody and M. M. Bosma Ion Channel Development, Spontaneous Activity, and Activity-Dependent Development in Nerve and Muscle Cells Physiol Rev, July 1, 2005; 85(3): 883 - 941. [Abstract] [Full Text] [PDF]

				The Neuroscientist Comments Neuroscientist, August 1, 2004; 10(4): 275 - 276. [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help