 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
The Journal of Neuroscience, March 31, 2004, 24(13):3379-3385; doi:10.1523/JNEUROSCI.5316-03.2004
Previous Article | Next Article
Behavioral/Systems/Cognitive
Preconditioning of Low-Frequency Repetitive Transcranial Magnetic Stimulation with Transcranial Direct Current Stimulation: Evidence for Homeostatic Plasticity in the Human Motor Cortex
Hartwig R. Siebner,1,2 Nicolas Lang,1,3 Vincenzo Rizzo,1,4 Michael A. Nitsche,3 Walter Paulus,3 Roger N. Lemon,1 andJohn C. Rothwell1 1Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College of London, London WC1N 3BG, United Kingdom, 2Department of Neurology, Christian-Albrechts University, 24105 Kiel, Germany, 3Department of Clinical Neurophysiology, Georg-August University, 37075 Göttingen, Germany, and 4Department of Neurosciences and Psychiatric and Anaesthesiological Sciences, University of Messina, 98125 Messina, Italy
Recent experimental work in animals has emphasized the importance of homeostatic plasticity as a means of stabilizing the properties of neuronal circuits. Here, we report a phenomenon that indicates a homeostatic pattern of cortical plasticity in healthy human subjects. The experiments combined two techniques that can produce long-term effects on the excitability of corticospinal output neurons: transcranial direct current stimulation (TDCS) and repetitive transcranial magnetic stimulation (rTMS) of the left primary motor cortex. "Facilitatory preconditioning" with anodal TDCS caused a subsequent period of 1 Hz rTMS to reduce corticospinal excitability to below baseline levels for >20 min. Conversely, "inhibitory preconditioning" with cathodal TDCS resulted in 1 Hz rTMS increasing corticospinal excitability for at least 20 min. No changes in excitability occurred when 1 Hz rTMS was preceded by sham TDCS. Thus, changing the initial state of the motor cortex by a period of DC polarization reversed the conditioning effects of 1 Hz rTMS. These preconditioning effects of TDCS suggest the existence of a homeostatic mechanism in the human motor cortex that stabilizes corticospinal excitability within a physiologically useful range.
Key words: corticospinal excitability; homeostatic plasticity; human motor cortex; transcranial magnetic stimulation; transcranial direct current stimulation; metaplasticity
Received Nov 13, 2003; revised February 23, 2004; accepted February 23, 2004.
This article has been cited by other articles:
M. Hamada, R. Hanajima, Y. Terao, S. Okabe, S. Nakatani-Enomoto, T. Furubayashi, H. Matsumoto, Y. Shirota, S. Ohminami, and Y. Ugawa
Primary motor cortical metaplasticity induced by priming over the supplementary motor area
J. Physiol., October 15, 2009; 587(20): 4845 - 4862.
[Abstract] [Full Text] [PDF]
P. Ragert, M. Camus, Y. Vandermeeren, M. A. Dimyan, and L. G. Cohen
Modulation of Effects of Intermittent Theta Burst Stimulation Applied Over Primary Motor Cortex (M1) by Conditioning Stimulation of the Opposite M1
J Neurophysiol, August 1, 2009; 102(2): 766 - 773.
[Abstract] [Full Text] [PDF]
C. A. Dockery, R. Hueckel-Weng, N. Birbaumer, and C. Plewnia
Enhancement of Planning Ability by Transcranial Direct Current Stimulation
J. Neurosci., June 3, 2009; 29(22): 7271 - 7277.
[Abstract] [Full Text] [PDF]
A. A. Karim, M. Schneider, M. Lotze, R. Veit, P. Sauseng, C. Braun, and N. Birbaumer
The Truth about Lying: Inhibition of the Anterior Prefrontal Cortex Improves Deceptive Behavior
Cereb Cortex, May 14, 2009; (2009) bhp090v1.
[Abstract] [Full Text] [PDF]
P. Jung and U. Ziemann
Homeostatic and Nonhomeostatic Modulation of Learning in Human Motor Cortex
J. Neurosci., April 29, 2009; 29(17): 5597 - 5604.
[Abstract] [Full Text] [PDF]
L. Avanzino, M. Bove, A. Tacchino, C. Trompetto, C. Ogliastro, and G. Abbruzzese
Interaction Between Finger Opposition Movements and Aftereffects of 1Hz-rTMS on Ipsilateral Motor Cortex
J Neurophysiol, March 1, 2009; 101(3): 1690 - 1694.
[Abstract] [Full Text] [PDF]
B. Cheeran, P. Talelli, F. Mori, G. Koch, A. Suppa, M. Edwards, H. Houlden, K. Bhatia, R. Greenwood, and J. C. Rothwell
A common polymorphism in the brain-derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS
J. Physiol., December 1, 2008; 586(23): 5717 - 5725.
[Abstract] [Full Text] [PDF]
A. Antal, N. Lang, K. Boros, M. Nitsche, H. R. Siebner, and W. Paulus
Homeostatic Metaplasticity of the Motor Cortex is Altered during Headache-Free Intervals in Migraine with Aura
Cereb Cortex, November 1, 2008; 18(11): 2701 - 2705.
[Abstract] [Full Text] [PDF]
E. Iezzi, A. Conte, A. Suppa, R. Agostino, L. Dinapoli, A. Scontrini, and A. Berardelli
Phasic Voluntary Movements Reverse the Aftereffects of Subsequent Theta-Burst Stimulation in Humans
J Neurophysiol, October 1, 2008; 100(4): 2070 - 2076.
[Abstract] [Full Text] [PDF]
R. Gentner, K. Wankerl, C. Reinsberger, D. Zeller, and J. Classen
Depression of Human Corticospinal Excitability Induced by Magnetic Theta-burst Stimulation: Evidence of Rapid Polarity-Reversing Metaplasticity
Cereb Cortex, September 1, 2008; 18(9): 2046 - 2053.
[Abstract] [Full Text] [PDF]
M. Hamada, Y. Terao, R. Hanajima, Y. Shirota, S. Nakatani-Enomoto, T. Furubayashi, H. Matsumoto, and Y. Ugawa
Bidirectional long-term motor cortical plasticity and metaplasticity induced by quadripulse transcranial magnetic stimulation
J. Physiol., August 15, 2008; 586(16): 3927 - 3947.
[Abstract] [Full Text] [PDF]
J. Silvanto, Z. Cattaneo, L. Battelli, and A. Pascual-Leone
Baseline Cortical Excitability Determines Whether TMS Disrupts or Facilitates Behavior
J Neurophysiol, May 1, 2008; 99(5): 2725 - 2730.
[Abstract] [Full Text] [PDF]
C. M. Stinear, P. A. Barber, J. P. Coxon, M. K. Fleming, and W. D. Byblow
Priming the motor system enhances the effects of upper limb therapy in chronic stroke
Brain, May 1, 2008; 131(5): 1381 - 1390.
[Abstract] [Full Text] [PDF]
Y.-Z. Huang, J. C. Rothwell, M. J. Edwards, and R.-S. Chen
Effect of Physiological Activity on an NMDA-Dependent Form of Cortical Plasticity in Human
Cereb Cortex, March 1, 2008; 18(3): 563 - 570.
[Abstract] [Full Text] [PDF]
K. Rosenkranz, K. Butler, A. Williamon, C. Cordivari, A. J. Lees, and J. C. Rothwell
Sensorimotor reorganization by proprioceptive training in musician's dystonia and writer's cramp
Neurology, January 22, 2008; 70(4): 304 - 315.
[Abstract] [Full Text] [PDF]
N. Lang, H. R. Siebner, Z. Chadaide, K. Boros, M. A. Nitsche, J. C. Rothwell, W. Paulus, and A. Antal
Bidirectional Modulation of Primary Visual Cortex Excitability: A Combined tDCS and rTMS Study
Invest. Ophthalmol. Vis. Sci., December 1, 2007; 48(12): 5782 - 5787.
[Abstract] [Full Text] [PDF]
V. M. Pomeroy, G. Cloud, R. C. Tallis, C. Donaldson, V. Nayak, and S. Miller
Transcranial Magnetic Stimulation and Muscle Contraction to Enhance Stroke Recovery: A Randomized Proof-of-Principle and Feasibility Investigation
Neurorehabil Neural Repair, December 1, 2007; 21(6): 509 - 517.
[Abstract] [PDF]
X. Y. Chen, S. Pillai, Y. Chen, Y. Wang, L. Chen, J. S. Carp, and J. R. Wolpaw
Spinal and Supraspinal Effects of Long-Term Stimulation of Sensorimotor Cortex in Rats
J Neurophysiol, August 1, 2007; 98(2): 878 - 887.
[Abstract] [Full Text] [PDF]
S. Rossi, A. De Capua, M. Ulivelli, S. Bartalini, V. Falzarano, G. Filippone, and S. Passero
Effects of repetitive transcranial magnetic stimulation on chronic tinnitus: a randomised, crossover, double blind, placebo controlled study
J. Neurol. Neurosurg. Psychiatry, August 1, 2007; 78(8): 857 - 863.
[Abstract] [Full Text] [PDF]
J. R. Carey, W. K. Durfee, E. Bhatt, A. Nagpal, S. A. Weinstein, K. M. Anderson, and S. M. Lewis
Comparison of Finger Tracking Versus Simple Movement Training via Telerehabilitation to Alter Hand Function and Cortical Reorganization After Stroke
Neurorehabil Neural Repair, May 1, 2007; 21(3): 216 - 232.
[Abstract] [PDF]
M. A. Nitsche, A. Roth, M.-F. Kuo, A. K. Fischer, D. Liebetanz, N. Lang, F. Tergau, and W. Paulus
Timing-Dependent Modulation of Associative Plasticity by General Network Excitability in the Human Motor Cortex
J. Neurosci., April 4, 2007; 27(14): 3807 - 3812.
[Abstract] [Full Text] [PDF]
P. M. Rossini and S. Rossi
Transcranial magnetic stimulation: Diagnostic, therapeutic, and research potential
Neurology, February 13, 2007; 68(7): 484 - 488.
[Abstract] [Full Text] [PDF]
D. Weise, A. Schramm, K. Stefan, A. Wolters, K. Reiners, M. Naumann, and J. Classen
The two sides of associative plasticity in writer's cramp
Brain, October 1, 2006; 129(10): 2709 - 2721.
[Abstract] [Full Text] [PDF]
Y. Ueki, T. Mima, K. Nakamura, T. Oga, H. Shibasaki, T. Nagamine, and H. Fukuyama
Transient Functional Suppression and Facilitation of Japanese Ideogram Writing Induced by Repetitive Transcranial Magnetic Stimulation of Posterior Inferior Temporal Cortex.
J. Neurosci., August 15, 2006; 26(33): 8523 - 8530.
[Abstract] [Full Text] [PDF]
K. Stefan, M. Wycislo, R. Gentner, A. Schramm, M. Naumann, K. Reiners, and J. Classen
Temporary Occlusion of Associative Motor Cortical Plasticity by Prior Dynamic Motor Training
Cereb Cortex, March 1, 2006; 16(3): 376 - 385.
[Abstract] [Full Text] [PDF]
G Ardolino, B Bossi, S Barbieri, and A Priori
Non-synaptic mechanisms underlie the after-effects of cathodal transcutaneous direct current stimulation of the human brain
J. Physiol., October 15, 2005; 568(2): 653 - 663.
[Abstract] [Full Text] [PDF]
M.-H. Monfils, E. J. Plautz, and J. A. Kleim
In Search of the Motor Engram: Motor Map Plasticity as a Mechanism for Encoding Motor Experience
Neuroscientist, October 1, 2005; 11(5): 471 - 483.
[Abstract] [PDF]
M. A Nitsche, A. Seeber, K. Frommann, C. C. Klein, C. Rochford, M. S Nitsche, K. Fricke, D. Liebetanz, N. Lang, A. Antal, et al.
Modulating parameters of excitability during and after transcranial direct current stimulation of the human motor cortex
J. Physiol., October 1, 2005; 568(1): 291 - 303.
[Abstract] [Full Text] [PDF]
A. Quartarone, V. Rizzo, S. Bagnato, F. Morgante, A. Sant'Angelo, M. Romano, D. Crupi, P. Girlanda, J. C. Rothwell, and H. R. Siebner
Homeostatic-like plasticity of the primary motor hand area is impaired in focal hand dystonia
Brain, August 1, 2005; 128(8): 1943 - 1950.
[Abstract] [Full Text] [PDF]
B. Fierro, F. Brighina, G. Vitello, A. Piazza, S. Scalia, G. Giglia, O. Daniele, and A. Pascual-Leone
Modulatory effects of low- and high-frequency repetitive transcranial magnetic stimulation on visual cortex of healthy subjects undergoing light deprivation
J. Physiol., June 1, 2005; 565(2): 659 - 665.
[Abstract] [Full Text] [PDF]
C. Buhmann, A. Gorsler, T. Baumer, U. Hidding, C. Demiralay, K. Hinkelmann, C. Weiller, H. R. Siebner, and A. Munchau
Abnormal excitability of premotor-motor connections in de novo Parkinson's disease
Brain, December 1, 2004; 127(12): 2732 - 2746.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|