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The Journal of Neuroscience, April 7, 2004, 24(14):3637-3642; doi:10.1523/JNEUROSCI.5458-03.2004

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Behavioral/Systems/Cognitive
Sensitivity to Auditory Object Features in Human Temporal Neocortex

Robert J. Zatorre,¹ Marc Bouffard,¹ and Pascal Belin²

¹Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada, and ²Department of Psychology, University of Montreal, Montreal, Quebec, Canada H3C 3J7

This positron emission tomography study examined the hemodynamic response of the human brain to auditory object feature processing. A continuum of object feature variation was created by combining different numbers of stimuli drawn from a diverse sample of 45 environmental sounds. In each 60 sec scan condition, subjects heard either a distinct individual sound on each trial or simultaneous combinations of sounds that varied systematically in their similarity or distinctiveness across conditions. As more stimuli are combined they become more similar and less distinct from one another; the limiting case is when all 45 are added together to form a noise that is repeated on each trial. Analysis of covariation of cerebral blood flow elicited by this parametric manipulation revealed a response in the upper bank of the right anterior superior temporal sulcus (STS): when sounds were identical across trials (i.e., a noise made up of 45 sounds), activity was at a minimum; when stimuli were different from one another, activity was maximal. A right inferior frontal area was also revealed. The results are interpreted as reflecting sensitivity of this region of temporal neocortex to auditory object features, as predicted by neurophysiological and anatomical models implicating an anteroventral functional stream in object processing. The findings also fit with evidence that voice processing may involve regions within the anterior STS. The data are discussed in light of these models and are related to the concept that this functional stream is sensitive to invariant sound features that characterize individual auditory objects.

Key words: auditory cortex; superior temporal sulcus; functional neuroimaging; auditory processing; auditory object

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Received Dec 11, 2003; revised February 11, 2004; accepted February 12, 2004.

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