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The Journal of Neuroscience, April 7, 2004, 24(14):3703-3710; doi:10.1523/JNEUROSCI.0188-04.2004

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Behavioral/Systems/Cognitive
Odors Detected by Mice Deficient in Cyclic Nucleotide-Gated Channel Subunit A2 Stimulate the Main Olfactory System

Weihong Lin,¹ Julie Arellano,¹ Burton Slotnick,² and Diego Restrepo¹

¹Department of Cell and Developmental Biology, Neuroscience Program and Rocky Mountain Taste and Smell Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, and ²Department of Psychology, University of South Florida, Tampa, Florida 33620

It is believed that odor transduction in the mammalian main olfactory system only involves the cAMP-signaling pathway. Here, we report on odor responsiveness in mice with a disrupted cyclic nucleotide-gated (CNG) channel subunit A2. Several odorants, including putative pheromones, can be detected and discriminated by these mice behaviorally. These odors elicit responses in the olfactory epithelium, main olfactory bulb, and olfactory (piriform) cortex of CNGA2 knock-out mice. In addition, responses to odors detected by CNGA2 knock-out mice are relatively insensitive to inhibitors of the cAMP pathway. These results provide strong evidence that cAMP-independent pathways in the main olfactory system of mammals participate in detecting a subset of odors.

Key words: cAMP; olfactory; transduction; operant; cyclic GMP; odor

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Received Jan 18, 2004; revised February 22, 2004; accepted February 23, 2004.

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