QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, April 14, 2004, 24(15):3816-3825; doi:10.1523/JNEUROSCI.5725-03.2004

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (28) Citing Articles via Google Scholar Google Scholar Articles by Decker, L. Articles by ffrench-Constant, C. Search for Related Content PubMed PubMed Citation Articles by Decker, L. Articles by ffrench-Constant, C. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB FUMONISIN B1 MANGANESE COMPOUNDS MANGANESE, ELEMENTAL

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Lipid Rafts and Integrin Activation Regulate Oligodendrocyte Survival

Laurence Decker and Charles ffrench-Constant

Departments of Pathology and Medical Genetics, and Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, CB2 1QP, United Kingdom

Newly formed oligodendrocytes in the CNS derive survival cues from their target axons. These cues are provided in part by laminins expressed on the axon, which are recognized by 61 integrin on the oligdendrocyte and amplify platelet-derived growth factor (PDGF) signaling through the phosphatidylinositol 3'-kinase (PI3K) pathway. The 61 integrin is localized in oligodendrocyte lipid rafts. We show here using the sphingolipid synthesis inhibitor fumonisin-B1 to deplete rafts that this localization is important for normal survival signaling, because depletion increases oligodendrocyte apoptosis and inhibits PI3K signaling. We have shown previously that PDGF-mediated integrin activation is an important component of oligodendrocyte proliferation signaling, and here we present evidence that a similar mechanism operates in survival signaling. Integrin activation using manganese increases raft localization and rescues the effects of both raft depletion and PDGF removal on survival and PI3K signaling. Together, these results point to an essential role for rafts in oligodendrocyte survival signaling on the basis of the provision of a favorable environment for growth factor-mediated integrin activation.

Key words: PDGF receptor; integrin activation; apoptosis; oligodendrocyte; PI3K; MAPK; lipid raft

---

Received June 13, 2003; revised March 1, 2004; accepted March 1, 2004.

This article has been cited by other articles:

				G. M. Fuhler, N. R. Blom, P. J. Coffer, A. L. Drayer, and E. Vellenga The reduced GM-CSF priming of ROS production in granulocytes from patients with myelodysplasia is associated with an impaired lipid raft formation J. Leukoc. Biol., February 1, 2007; 81(2): 449 - 457. [Abstract] [Full Text] [PDF]

				K. Gaus, S. Le Lay, N. Balasubramanian, and M. A. Schwartz Integrin-mediated adhesion regulates membrane order J. Cell Biol., August 28, 2006; 174(5): 725 - 734. [Abstract] [Full Text] [PDF]

				L. S. Campos, L. Decker, V. Taylor, and W. Skarnes Notch, Epidermal Growth Factor Receptor, and beta1-Integrin Pathways Are Coordinated in Neural Stem Cells J. Biol. Chem., February 24, 2006; 281(8): 5300 - 5309. [Abstract] [Full Text] [PDF]

				I. Cascone, L. Napione, F. Maniero, G. Serini, and F. Bussolino Stable interaction between {alpha}5{beta}1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1 J. Cell Biol., September 12, 2005; 170(6): 993 - 1004. [Abstract] [Full Text] [PDF]

				A. Schneider, H. Lander, G. Schulz, H. Wolburg, K.-A. Nave, J. B. Schulz, and M. Simons Palmitoylation is a sorting determinant for transport to the myelin membrane J. Cell Sci., June 1, 2005; 118(11): 2415 - 2423. [Abstract] [Full Text] [PDF]

				H. Colognato, S. Ramachandrappa, I. M. Olsen, and C. ffrench-Constant Integrins direct Src family kinases to regulate distinct phases of oligodendrocyte development J. Cell Biol., October 25, 2004; 167(2): 365 - 375. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help