 |
||||
|
||||
|
||||
|
||||
|
||||
The Journal of Neuroscience, April 21, 2004, 24(16):3985-3998; doi:10.1523/JNEUROSCI.5782-03.2004
Previous Article | Next Article
Behavioral/Systems/Cognitive
Synaptic Responses to Whisker Deflections in Rat Barrel Cortex as a Function of Cortical Layer and Stimulus Intensity
W. Bryan Wilent andDiego Contreras Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19106-6074
To study the synaptic and spike responses of barrel cortex neurons as a function of cortical layer and stimulus intensity, we recorded intracellularly in vivo from barbiturate anesthetized rats while increasing the velocity-acceleration of the whisker deflection. Granular (Gr; layer 4) cells had the EPSP with the shortest peak and onset latency, whereas supragranular (SGr; layers 2-3) cells had the EPSP with longest duration and slowest rate of rise. Infragranular (Igr; layers 5-6) cells had intermediate values, and thus each layer was unique. The spike response peak of Gr cells was followed by IGr and then by SGr cells. In all cells, depolarization reduced the duration and amplitude of the response, but only in Gr cells did it reveal an early IPSP that cut short the EPSP. This early IPSP was associated with a large decrease in input resistance and an apparent reversal potential below spike threshold; consequently, synaptic integration in Gr cells was limited to the initial 5-7 msec of the response. In contrast, in SGr and IGr cells, results suggest an overlap in time of the EPSP and IPSP, with a small drop in input resistance and an apparent reversal potential above spike threshold, facilitating input integration for up to 20 msec. Decreasing stimulus intensity (velocity-acceleration) reduced the amplitude and increased the peak latency of the response without altering its synaptic composition. We propose that layer 4 circuits are better suited to perform coincidence detection, whereas supra and infragranular circuits are better designed for input integration.
Key words: barrel; cortex; EPSP; inhibition; intracellular; IPSP; synaptic; velocity; whisker; in vivo; integration; acceleration
Received Oct 8, 2003; revised February 15, 2004; accepted March 9, 2004.
This article has been cited by other articles:
A. W. Moreau, M. Amar, N. Le Roux, N. Morel, and P. Fossier
Serotoninergic Fine-Tuning of the Excitation-Inhibition Balance in Rat Visual Cortical Networks
Cereb Cortex, July 8, 2009; (2009) bhp114v3.
[Abstract] [Full Text] [PDF]
E. Lottem and R. Azouz
Dynamic Translation of Surface Coarseness Into Whisker Vibrations
J Neurophysiol, November 1, 2008; 100(5): 2852 - 2865.
[Abstract] [Full Text] [PDF]
S. Temereanca, E. N. Brown, and D. J. Simons
Rapid Changes in Thalamic Firing Synchrony during Repetitive Whisker Stimulation
J. Neurosci., October 29, 2008; 28(44): 11153 - 11164.
[Abstract] [Full Text] [PDF]
P. Kumar and O. Ohana
Inter- and Intralaminar Subcircuits of Excitatory and Inhibitory Neurons in Layer 6a of the Rat Barrel Cortex
J Neurophysiol, October 1, 2008; 100(4): 1909 - 1922.
[Abstract] [Full Text] [PDF]
G. Foffani, J. K. Chapin, and K. A. Moxon
Computational Role of Large Receptive Fields in the Primary Somatosensory Cortex
J Neurophysiol, July 1, 2008; 100(1): 268 - 280.
[Abstract] [Full Text] [PDF]
S. Sadagopan and X. Wang
Level Invariant Representation of Sounds by Populations of Neurons in Primary Auditory Cortex
J. Neurosci., March 26, 2008; 28(13): 3415 - 3426.
[Abstract] [Full Text] [PDF]
Z. Tan, H. Hu, Z. J. Huang, and A. Agmon
Robust but delayed thalamocortical activation of dendritic-targeting inhibitory interneurons
PNAS, February 12, 2008; 105(6): 2187 - 2192.
[Abstract] [Full Text] [PDF]
A. Frick, D. Feldmeyer, M. Helmstaedter, and B. Sakmann
Monosynaptic Connections between Pairs of L5A Pyramidal Neurons in Columns of Juvenile Rat Somatosensory Cortex
Cereb Cortex, February 1, 2008; 18(2): 397 - 406.
[Abstract] [Full Text] [PDF]
A. Frick, D. Feldmeyer, and B. Sakmann
Postnatal development of synaptic transmission in local networks of L5A pyramidal neurons in rat somatosensory cortex
J. Physiol., November 15, 2007; 585(1): 103 - 116.
[Abstract] [Full Text] [PDF]
R. D. Kumbhani, M. J. Nolt, and L. A. Palmer
Precision, Reliability, and Information-Theoretic Analysis of Visual Thalamocortical Neurons
J Neurophysiol, November 1, 2007; 98(5): 2647 - 2663.
[Abstract] [Full Text] [PDF]
D. J. Simons, G. E. Carvell, H. T. Kyriazi, and R. M. Bruno
Thalamocortical Conduction Times and Stimulus-Evoked Responses in the Rat Whisker-to-Barrel System
J Neurophysiol, November 1, 2007; 98(5): 2842 - 2847.
[Abstract] [Full Text] [PDF]
S.-H. Lee, P. W. Land, and D. J. Simons
Layer- and Cell-Type-Specific Effects of Neonatal Whisker-Trimming in Adult Rat Barrel Cortex
J Neurophysiol, June 1, 2007; 97(6): 4380 - 4385.
[Abstract] [Full Text] [PDF]
C. P. J. de Kock, R. M. Bruno, H. Spors, and B. Sakmann
Layer- and cell-type-specific suprathreshold stimulus representation in rat primary somatosensory cortex
J. Physiol., May 15, 2007; 581(1): 139 - 154.
[Abstract] [Full Text] [PDF]
C. Quairiaux, M. Armstrong-James, and E. Welker
Modified Sensory Processing in the Barrel Cortex of the Adult Mouse After Chronic Whisker Stimulation
J Neurophysiol, March 1, 2007; 97(3): 2130 - 2147.
[Abstract] [Full Text] [PDF]
V. Khatri and D. J. Simons
Angularly Nonspecific Response Suppression in Rat Barrel Cortex
Cereb Cortex, March 1, 2007; 17(3): 599 - 609.
[Abstract] [Full Text] [PDF]
M. J. Higley and D. Contreras
Cellular Mechanisms of Suppressive Interactions Between Somatosensory Responses In Vivo
J Neurophysiol, January 1, 2007; 97(1): 647 - 658.
[Abstract] [Full Text] [PDF]
D. M. Devilbiss, M. E. Page, and B. D. Waterhouse
Locus Ceruleus Regulates Sensory Encoding by Neurons and Networks in Waking Animals
J. Neurosci., September 27, 2006; 26(39): 9860 - 9872.
[Abstract] [Full Text] [PDF]
H. Hentschke, F. Haiss, and C. Schwarz
Central Signals Rapidly Switch Tactile Processing in Rat Barrel Cortex during Whisker Movements
Cereb Cortex, August 1, 2006; 16(8): 1142 - 1156.
[Abstract] [Full Text] [PDF]
E. F. Civillico and D. Contreras
Integration of Evoked Responses in Supragranular Cortex Studied With Optical Recordings In Vivo
J Neurophysiol, July 1, 2006; 96(1): 336 - 351.
[Abstract] [Full Text] [PDF]
M. J. Higley and D. Contreras
Balanced Excitation and Inhibition Determine Spike Timing during Frequency Adaptation
J. Neurosci., January 11, 2006; 26(2): 448 - 457.
[Abstract] [Full Text] [PDF]
E. Foeller, T. Celikel, and D. E. Feldman
Inhibitory Sharpening of Receptive Fields Contributes to Whisker Map Plasticity in Rat Somatosensory Cortex
J Neurophysiol, December 1, 2005; 94(6): 4387 - 4400.
[Abstract] [Full Text] [PDF]
M. J. Higley and D. Contreras
Integration of Synaptic Responses to Neighboring Whiskers in Rat Barrel Cortex In Vivo
J Neurophysiol, April 1, 2005; 93(4): 1920 - 1934.
[Abstract] [Full Text] [PDF]
W. B. Wilent and D. Contreras
Stimulus-Dependent Changes in Spike Threshold Enhance Feature Selectivity in Rat Barrel Cortex Neurons
J. Neurosci., March 16, 2005; 25(11): 2983 - 2991.
[Abstract] [Full Text] [PDF]
E. E. Kwegyir-Afful and A. Keller
Response Properties of Whisker-Related Neurons in Rat Second Somatosensory Cortex
J Neurophysiol, October 1, 2004; 92(4): 2083 - 2092.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|