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The Journal of Neuroscience, April 28, 2004, 24(17):4113-4123; doi:10.1523/JNEUROSCI.5322-03.2004

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Behavioral/Systems/Cognitive
Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

Frances A. Champagne, Pablo Chretien, Carl W. Stevenson, Tie Yuan Zhang, Alain Gratton, and Michael J. Meaney

Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, Montreal, Quebec H4H 1R3, Canada

Lactating rats exhibit stable individual differences in pup licking/grooming. We used in vivo voltammetry to monitor changes in extracellular dopamine (DA) in the nucleus accumbens (n. Acc) shell of lactating rats interacting with pups and found that (1) the DA signal increased significantly with pup licking/grooming; (2) the onset of such increases preceded pup licking/grooming; and (3) the magnitude and duration of the increase in the DA signal were significantly correlated with the duration of the licking/grooming bout. In females characterized on the basis of behavioral observations as high-licking/grooming mothers, the magnitude of the increase in the DA signal associated with licking/grooming was significantly greater than in low-licking/grooming dams. Dopamine transporter binding in the n. Acc was increased in low-compared with high-licking/grooming mothers. Injection of the selective DA uptake inhibitor GBR 12909 [1-(2-(Bis-(4-fluorophenyl)methoxy)ethyl)-4-(3 phenypropyl)piperazine dihydrochloride] (5 mg/kg, s.c.) increased the DA signal in the n. Acc and pup licking/grooming in low-licking/grooming mothers to levels comparable with those observed in high-licking/grooming dams. Receptor autoradiographic studies showed elevated levels of D₁ and D₃ receptors in the n. Acc shell region in high-licking/grooming dams. These results suggest that high- and low-licking/grooming dams differ in mesolimbic dopaminergic activity associated with mother-pup interactions. Such differences may serve as neural substrates for individual differences in the motivational component of maternal behavior.

Key words: maternal; behavior; dopamine; dopamine receptors; nucleus accumbens; voltammetry

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Received Sep 8, 2003; revised March 12, 2004; accepted March 12, 2004.

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