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The Journal of Neuroscience, May 12, 2004, 24(19):4625-4634; doi:10.1523/JNEUROSCI.0318-04.2004

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Cellular/Molecular
Contribution of AMPA, NMDA, and GABA_A Receptors to Temporal Pattern of Postsynaptic Responses in the Inferior Colliculus of the Rat

Shu Hui Wu, Chun Lei Ma, and Jack B. Kelly

Institute of Neuroscience, Carleton University, Ottawa, Ontario K1S 5B6, Canada

The central nucleus of the inferior colliculus (ICC) is a major site of synaptic interaction in the central auditory system. To understand how ICC neurons integrate excitatory and inhibitory inputs for processing temporal information, we examined postsynaptic responses of ICC neurons to repetitive stimulation of the lateral lemniscus at 10-100 Hz in rat brain slices. The excitatory synaptic currents mediated by AMPA and NMDA receptors and the inhibitory current mediated by GABA_A receptors were pharmacologically isolated and recorded by whole-cell patch-clamp techniques. The response kinetics of AMPA receptor-mediated EPSCs and GABA_A receptor-mediated IPSCs were similar and much faster than those of NMDA receptor-mediated EPSCs. AMPA EPSCs could follow each pulse of stimulation at a rate of 10-100 Hz but showed response depression during the course of repetitive stimulation. GABA_A IPSCs could also follow stimulus pulses over this frequency range but showed depression at low rates and facilitation at higher rates. NMDA EPSCs showed facilitation and temporal summation in response to repetitive stimulation, which was most pronounced at higher rates of stimulation. GABA_A inhibition suppressed activation of NMDA receptors and reduced both the degree of AMPA EPSC depression and the extent of temporal summation of NMDA EPSCs. The results indicate that GABA_A receptor-mediated inhibition plays a crucial role in maintaining the balance of excitation and inhibition and in allowing ICC neurons to process temporal information more precisely.

Key words: auditory system; patch-clamp recording; AMPA receptor; NMDA receptor; GABA_A receptor; temporal processing

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Received Jan 28, 2004; revised April 6, 2004; accepted April 7, 2004.

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