QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, January 14, 2004, 24(2):310-318; doi:10.1523/JNEUROSCI.4287-03.2004

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (26) Citing Articles via Google Scholar Google Scholar Articles by Liu, Y. Articles by Halloran, M. C. Search for Related Content PubMed PubMed Citation Articles by Liu, Y. Articles by Halloran, M. C. Pubmed/NCBI databases Gene GEO Profiles HomoloGene Nucleotide Protein UniGene Substance via MeSH

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Semaphorin3D Guides Retinal Axons along the Dorsoventral Axis of the Tectum

Yan Liu,¹ Jason Berndt,^1,2 Fengyun Su,³ Hiroshi Tawarayama,⁴ Wataru Shoji,⁴ John Y. Kuwada,³ and Mary C. Halloran^1,2

¹Departments of Zoology and Anatomy and ²Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin 53706, ³Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, 48109-1048, and ⁴Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980-8575, Japan

We examined the role of Sema3D, a semaphorin of previously unknown function, in guiding retinal ganglion cell (RGC) axons to the optic tectum in the developing zebrafish. Sema3D is expressed more strongly in the ventral versus dorsal tectum, suggesting that it may participate in guiding RGC axons along the dorsoventral axis of the tectum. Ubiquitous misexpression of Sema3D in transgenic zebrafish inhibits ventral but not dorsal RGC axon growth. In addition, ventral RGC axons avoid or stop at individual cells misexpressing Sema3D along their pathway. Sema3D ubiquitous misexpression at later stages also causes ventral RGC axon arbors to spread more widely along the dorsoventral axis of the tectum. Knock-down of Sema3D with morpholino antisense causes ventral RGC axons to extend aberrantly into the ventral tectum. These results suggest that Sema3D in the ventral tectum normally acts to inhibit ventral RGCs from extending into ventral tectum, ensuring their correct innervation of dorsal tectum.

Key words: semaphorin; neuropilin; retinal axon guidance; retinotectal; transgenic zebrafish; topographic map

---

Received Sep 20, 2003; accepted October 13, 2003.

This article has been cited by other articles:

				M. A. Wolman, A. M. Regnery, T. Becker, C. G. Becker, and M. C. Halloran Semaphorin3D Regulates Axon Axon Interactions by Modulating Levels of L1 Cell Adhesion Molecule J. Neurosci., September 5, 2007; 27(36): 9653 - 9663. [Abstract] [Full Text] [PDF]

				K. A. McClellan, V. A. Ruzhynsky, D. N. Douda, J. L. Vanderluit, K. L. Ferguson, D. Chen, R. Bremner, D. S. Park, G. Leone, and R. S. Slack Unique Requirement for Rb/E2F3 in Neuronal Migration: Evidence for Cell Cycle-Independent Functions Mol. Cell. Biol., July 1, 2007; 27(13): 4825 - 4843. [Abstract] [Full Text] [PDF]

				Y.-S. Kuan, H.-H. Yu, C. B. Moens, and M. E. Halpern Neuropilin asymmetry mediates a left-right difference in habenular connectivity Development, March 1, 2007; 134(5): 857 - 865. [Abstract] [Full Text] [PDF]

				J. D. Berndt and M. C. Halloran Semaphorin 3d promotes cell proliferation and neural crest cell development downstream of TCF in the zebrafish hindbrain Development, October 15, 2006; 133(20): 3983 - 3992. [Abstract] [Full Text] [PDF]

				J. A. Sakai and M. C. Halloran Semaphorin 3d guides laterality of retinal ganglion cell projections in zebrafish Development, March 15, 2006; 133(6): 1035 - 1044. [Abstract] [Full Text] [PDF]

				M. Sato-Maeda, H. Tawarayama, M. Obinata, J. Y. Kuwada, and W. Shoji Sema3a1 guides spinal motor axons in a cell- and stage-specific manner in zebrafish Development, March 1, 2006; 133(5): 937 - 947. [Abstract] [Full Text] [PDF]

				Y. Liu and M. C. Halloran Central and Peripheral Axon Branches from One Neuron Are Guided Differentially by Semaphorin3D and Transient Axonal Glycoprotein-1 J. Neurosci., November 9, 2005; 25(45): 10556 - 10563. [Abstract] [Full Text] [PDF]

				T. Xiao, T. Roeser, W. Staub, and H. Baier A GFP-based genetic screen reveals mutations that disrupt the architecture of the zebrafish retinotectal projection Development, July 1, 2005; 132(13): 2955 - 2967. [Abstract] [Full Text] [PDF]

				F. de Winter, Q. Cui, N. Symons, J. Verhaagen, and A. R. Harvey Expression of Class-3 Semaphorins and Their Receptors in the Neonatal and Adult Rat Retina Invest. Ophthalmol. Vis. Sci., December 1, 2004; 45(12): 4554 - 4562. [Abstract] [Full Text] [PDF]

				M. A. Wolman, Y. Liu, H. Tawarayama, W. Shoji, and M. C. Halloran Repulsion and Attraction of Axons by Semaphorin3D Are Mediated by Different Neuropilins In Vivo J. Neurosci., September 29, 2004; 24(39): 8428 - 8435. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help