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The Journal of Neuroscience, January 14, 2004, 24(2):398-411; doi:10.1523/JNEUROSCI.4032-03.2004

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Behavioral/Systems/Cognitive
Serotonin Enhances the Resistance Reflex of the Locomotor Network of the Crayfish through Multiple Modulatory Effects that Act Cooperatively

Morgane Le Bon-Jego,¹ Daniel Cattaert,¹ and Edouard Pearlstein²

¹Laboratoire de Neurobiologie des Réseaux, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5816, Biologie Animale, Bâtiment B2, 33405 Talence cedex, France, and ²Développement et Dysfonctionnement des Réseaux Locomoteurs, Centre National de la Recherche Scientifique, 13402 Marseille cedex 20, France

Serotonin (5HT) is an endogenous amine that modifies posture in crustacea. Here, we examined the mechanisms of action of 5HT on the resistance reflex in crayfish legs. This reflex, which counteracts movements imposed on a limb, is based on a negative feedback system formed by proprioceptors that sense joint angle movements and activate opposing motoneurons. We performed intracellular recordings from depressor motoneurons while repetitively stretching and releasing a leg joint proprioceptor in a resting in vitro preparation (i.e., a preparation that lacks spontaneous rhythmic activity). 5HT increased the amplitude of the depolarization during the release phase of the proprioceptor (corresponding to an upward movement of the leg) and the discharge frequency of the motoneurons. The 5HT-induced increase in the resistance reflex is caused, to a large extent, by polysynaptic pathways because it was very attenuated in the presence of high divalent cation solution. In addition to this activation of the polysynaptic pathways, 5HT also has postsynaptic effects that enhance the resistance reflex. 5HT causes a tonic depolarization, as well as an increase in the time constant and input resistance of motoneurons. We developed a simple mathematical model to describe the integrative properties of the motoneurons. The conclusion of this study is that the input frequency and the decay time constant of the EPSPs interact in such a way that small simultaneous changes in these parameters can cause a large effect on summation. Therefore, the conjunction of presynaptic and postsynaptic changes produces a strong cooperative effect on the resistance reflex response.

Key words: crustacea; stretch reflex; neuromodulation; posture; serotonin; crayfish

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Received June 20, 2003; revised October 21, 2003; accepted October 21, 2003.

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