QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, June 2, 2004, 24(22):5131-5139; doi:10.1523/JNEUROSCI.1021-04.2004

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (86) Citing Articles via Google Scholar Google Scholar Articles by Tseng, K. Y. Articles by O'Donnell, P. Search for Related Content PubMed PubMed Citation Articles by Tseng, K. Y. Articles by O'Donnell, P. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CALCIUM COMPOUNDS CALCIUM, ELEMENTAL DOPAMINE GLUTAMIC ACID HYDROCHLORIDE

 Previous Article  |  Next Article 

Cellular/Molecular
Dopamine–Glutamate Interactions Controlling Prefrontal Cortical Pyramidal Cell Excitability Involve Multiple Signaling Mechanisms

Kuei Y. Tseng and Patricio O'Donnell

Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208

Although the importance of dopamine (DA) for prefrontal cortical (PFC) cognitive functions is widely recognized, the nature of DA actions in the PFC remains controversial. A critical component in DA actions is its modulation of glutamate transmission, which can be different when specific receptors are activated. To obtain a clear picture of cellular mechanisms involved in these interactions, we studied the effects of DA–glutamate coactivation on pyramidal cell excitability in brain slices obtained from developmentally mature rats using whole-cell patch-clamp recordings. Bath application of NMDA, AMPA, and the D1 agonist SKF38393induced concentration-dependent excitability increases, whereas bath application of the D2 receptor agonist quinpirole induced a concentration-dependent excitability decrease. The NMDA-mediated response was potentiated by SKF38393 This NMDA–D1 synergism required postsynaptic intracellular Ca²⁺ and protein kinase A (PKA) and was independent of membrane depolarization. On the other hand, the excitatory effects of both NMDA and AMPA were attenuated by a D2 agonist. Surprisingly, the D2–NMDA interaction was also blocked by the GABA_A antagonists bicuculline and picrotoxin, suggesting that the inhibitory action of D2 receptors on NMDA-induced responses in the PFC may be mediated by GABAergic interneurons. In contrast, the D2–AMPA interaction involves inhibition of PKA and activation of phospholipase lipase C–IP₃ and intracellular Ca²⁺ at a postsynaptic level. Thus, the modulatory actions of D1 and D2 receptors on PFC pyramidal cell excitability are mediated by multiple intracellular mechanisms and by activation of GABA_A receptors, depending on the glutamate receptor subtypes involved.

Key words: prefrontal cortex; dopamine receptors; AMPA; NMDA; whole-cell patch clamp; electrophysiology

---

Received Feb 9, 2004; revised April 26, 2004; accepted April 26, 2004.

This article has been cited by other articles:

				B. Kolomiets, A. Marzo, J. Caboche, P. Vanhoutte, and S. Otani Background Dopamine Concentration Dependently Facilitates Long-term Potentiation in Rat Prefrontal Cortex through Postsynaptic Activation of Extracellular Signal-Regulated Kinases Cereb Cortex, November 1, 2009; 19(11): 2708 - 2718. [Abstract] [Full Text] [PDF]

				F. Kasanetz and O. J. Manzoni Maturation of Excitatory Synaptic Transmission of the Rat Nucleus Accumbens From Juvenile to Adult J Neurophysiol, May 1, 2009; 101(5): 2516 - 2527. [Abstract] [Full Text] [PDF]

				K. E. Stephan, K. J. Friston, and C. D. Frith Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring Schizophr Bull, May 1, 2009; 35(3): 509 - 527. [Abstract] [Full Text] [PDF]

				N. Santana, G. Mengod, and F. Artigas Quantitative Analysis of the Expression of Dopamine D1 and D2 Receptors in Pyramidal and GABAergic Neurons of the Rat Prefrontal Cortex Cereb Cortex, April 1, 2009; 19(4): 849 - 860. [Abstract] [Full Text] [PDF]

				P. L. Tierney, A. M. Thierry, J. Glowinski, J. M. Deniau, and Y. Gioanni Dopamine Modulates Temporal Dynamics of Feedforward Inhibition in Rat Prefrontal Cortex In Vivo Cereb Cortex, October 1, 2008; 18(10): 2251 - 2262. [Abstract] [Full Text] [PDF]

				Y. Zhang, M. M. Behrens, and J. E. Lisman Prolonged Exposure to NMDAR Antagonist Suppresses Inhibitory Synaptic Transmission in Prefrontal Cortex J Neurophysiol, August 1, 2008; 100(2): 959 - 965. [Abstract] [Full Text] [PDF]

				K. Thurley, W. Senn, and H.-R. Luscher Dopamine Increases the Gain of the Input-Output Response of Rat Prefrontal Pyramidal Neurons J Neurophysiol, June 1, 2008; 99(6): 2985 - 2997. [Abstract] [Full Text] [PDF]

				H. Trantham-Davidson, S. Kroner, and J. K. Seamans Dopamine Modulation of Prefrontal Cortex Interneurons Occurs Independently of DARPP-32 Cereb Cortex, April 1, 2008; 18(4): 951 - 958. [Abstract] [Full Text] [PDF]

				L. Orozco-Cabal, J. Liu, S. Pollandt, K. Schmidt, P. Shinnick-Gallagher, and J. P. Gallagher Dopamine and Corticotropin-Releasing Factor Synergistically Alter Basolateral Amygdala-to-Medial Prefrontal Cortex Synaptic Transmission: Functional Switch after Chronic Cocaine Administration J. Neurosci., January 9, 2008; 28(2): 529 - 542. [Abstract] [Full Text] [PDF]

				N. Wu, C. Cepeda, X. Zhuang, and M. S. Levine Altered Corticostriatal Neurotransmission and Modulation in Dopamine Transporter Knock-Down Mice J Neurophysiol, July 1, 2007; 98(1): 423 - 432. [Abstract] [Full Text] [PDF]

				S. Bandyopadhyay and J. J. Hablitz Dopaminergic Modulation of Local Network Activity in Rat Prefrontal Cortex J Neurophysiol, June 1, 2007; 97(6): 4120 - 4128. [Abstract] [Full Text] [PDF]

				A. Mouri, Y. Noda, A. Noda, T. Nakamura, T. Tokura, Y. Yura, A. Nitta, H. Furukawa, and T. Nabeshima Involvement of a Dysfunctional Dopamine-D1/N-Methyl-D-aspartate-NR1 and Ca2+/Calmodulin-Dependent Protein Kinase II Pathway in the Impairment of Latent Learning in a Model of Schizophrenia Induced by Phencyclidine Mol. Pharmacol., June 1, 2007; 71(6): 1598 - 1609. [Abstract] [Full Text] [PDF]

				S. Kroner, L. S. Krimer, D. A. Lewis, and G. Barrionuevo Dopamine Increases Inhibition in the Monkey Dorsolateral Prefrontal Cortex through Cell Type-Specific Modulation of Interneurons Cereb Cortex, May 1, 2007; 17(5): 1020 - 1032. [Abstract] [Full Text] [PDF]

				K.-Y. Tseng and P. O'Donnell Dopamine Modulation of Prefrontal Cortical Interneurons Changes during Adolescence Cereb Cortex, May 1, 2007; 17(5): 1235 - 1240. [Abstract] [Full Text] [PDF]

				D. Durstewitz and T. Gabriel Dynamical Basis of Irregular Spiking in NMDA-Driven Prefrontal Cortex Neurons Cereb Cortex, April 1, 2007; 17(4): 894 - 908. [Abstract] [Full Text] [PDF]

				L. Chen, J. D. Bohanick, M. Nishihara, J. K. Seamans, and C. R. Yang Dopamine D1/5 Receptor-Mediated Long-Term Potentiation of Intrinsic Excitability in Rat Prefrontal Cortical Neurons: Ca2+-Dependent Intracellular Signaling J Neurophysiol, March 1, 2007; 97(3): 2448 - 2464. [Abstract] [Full Text] [PDF]

				M. F. Perez, F. J. White, and X.-T. Hu Dopamine D2 Receptor Modulation of K+ Channel Activity Regulates Excitability of Nucleus Accumbens Neurons at Different Membrane Potentials J Neurophysiol, November 1, 2006; 96(5): 2217 - 2228. [Abstract] [Full Text] [PDF]

				B. Schilstrom, R. Yaka, E. Argilli, N. Suvarna, J. Schumann, B. T. Chen, M. Carman, V. Singh, W. S. Mailliard, D. Ron, et al. Cocaine Enhances NMDA Receptor-Mediated Currents in Ventral Tegmental Area Cells via Dopamine D5 Receptor-Dependent Redistribution of NMDA Receptors. J. Neurosci., August 15, 2006; 26(33): 8549 - 8558. [Abstract] [Full Text] [PDF]

				C. V. Stewart and D. Plenz Inverted-U Profile of Dopamine-NMDA-Mediated Spontaneous Avalanche Recurrence in Superficial Layers of Rat Prefrontal Cortex J. Neurosci., August 2, 2006; 26(31): 8148 - 8159. [Abstract] [Full Text] [PDF]

				C. Cepeda and M. S. Levine Where Do You Think You Are Going? The NMDA-D1 Receptor Trap Sci. Signal., May 2, 2006; 2006(333): pe20 - pe20. [Abstract] [Full Text] [PDF]

				J. D. Peterson, M. E. Wolf, and F. J. White Repeated amphetamine administration decreases D1 dopamine receptor-mediated inhibition of voltage-gated sodium currents in the prefrontal cortex. J. Neurosci., March 22, 2006; 26(12): 3164 - 3168. [Abstract] [Full Text] [PDF]

				J. A. Rosenkranz and D. Johnston Dopaminergic regulation of neuronal excitability through modulation of Ih in layer V entorhinal cortex. J. Neurosci., March 22, 2006; 26(12): 3229 - 3244. [Abstract] [Full Text] [PDF]

				R. Benavides-Piccione, J. I. Arellano, and J. DeFelipe Catecholaminergic Innervation of Pyramidal Neurons in the Human Temporal Cortex Cereb Cortex, October 1, 2005; 15(10): 1584 - 1591. [Abstract] [Full Text] [PDF]

				H. Trantham-Davidson, L. C. Neely, A. Lavin, and J. K. Seamans Mechanisms Underlying Differential D1 versus D2 Dopamine Receptor Regulation of Inhibition in Prefrontal Cortex J. Neurosci., November 24, 2004; 24(47): 10652 - 10659. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help