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The Journal of Neuroscience, June 2, 2004, 24(22):5172-5176; doi:10.1523/JNEUROSCI.1042-04.2004
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BRIEF COMMUNICATION
Removal of AMPA Receptors (AMPARs) from Synapses Is Preceded by Transient Endocytosis of Extrasynaptic AMPARs
Michael C. Ashby,1 Sarah A. De La Rue,1 G. Scott Ralph,1,2 James Uney,2 Graham L. Collingridge,1 andJeremy M. Henley1 1Medical Research Council (MRC) Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom, 2MRC Centre for Synaptic Plasticity, Division of Medicine, University of Bristol, Bristol BS2 8HW, United Kingdom
AMPA receptors (AMPARs) are dynamically regulated at synapses, but the time course and location of their exocytosis and endocytosis are not known. Therefore, we have used ecliptic pHluorin-tagged glutamate receptor 2 to visualize changes in AMPAR surface expression in real time. We show that synaptic and extrasynaptic AMPARs respond very differently to NMDA receptor activation; there is a rapid internalization of extrasynaptic AMPARs that precedes the delayed removal of synaptic AMPARs.
Key words: AMPARs; trafficking; imaging; cell surface; pHluorin; hippocampus
Received March 22, 2004; revised April 18, 2004; accepted April 23, 2004.
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