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The Journal of Neuroscience, July 21, 2004, 24(29):6497-6506; doi:10.1523/JNEUROSCI.4970-03.2004

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Behavioral/Systems/Cognitive
Novel Environments Enhance the Induction and Maintenance of Long-Term Potentiation in the Dentate Gyrus

Cyndy D. Davis, Floretta L. Jones, and Brian E. Derrick

Department of Biology and Cajal Neuroscience Research Center, The University of Texas at San Antonio, San Antonio, Texas 78249-0662

The induction of long-term potentiation (LTP) in the hippocampal formation can be modulated by different behavioral states. However, few studies have addressed modulation of LTP during behavioral states in which the animal is likely acquiring new information. Here, we demonstrate that both the induction and the longevity of LTP in the dentate gyrus are enhanced when LTP is induced during the initial exploration of a novel environment. These effects are independent from locomotor activity, changes in brain temperature, and theta rhythm. Previous exposure to the novel environment attenuated this enhancement, suggesting that the effects of novelty habituate with familiarity. LTP longevity also was enhanced when induced in familiar environments containing novel objects. Together, these data indicate that both LTP induction and maintenance are enhanced when LTP is induced while rats investigate novel stimuli. We suggest that novelty initiates a transition of the hippocampal formation to a mode that is particularly conducive to synaptic plasticity, a process that could allow for new learning while preserving the stability of previously stored information. In addition, LTP induced in novel environments elicited a sustained late LTP. This suggests that a single synaptic population can display distinct profiles of LTP maintenance and that this depends on the animal's behavioral state during its induction. Furthermore, the duration of LTP enhanced by novelty parallels the time period during which the hippocampal formation is thought necessary for memory, consistent with the view that dentate LTP is of a duration sufficient to sustain memory in the hippocampal formation.

Key words: long-term potentiation (LTP); dentate gyrus; novelty; theta rhythm; hippocampus; fascia dentata

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Received Nov 5, 2003; revised May 27, 2004; accepted June 1, 2004.

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