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The Journal of Neuroscience, July 21, 2004, 24(29):6621-6628; doi:10.1523/JNEUROSCI.1474-04.2004

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Cellular/Molecular
cGMP-Dependent Kinase Regulates Response Sensitivity of the Mouse On Bipolar Cell

Josefin Snellman¹ and Scott Nawy^1,2

Departments of ¹Neuroscience and ²Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, The Rose F. Kennedy Center, Bronx, New York 10461

The visual system can adjust its sensitivity over a wide range of light intensities. Photoreceptors account for some of this adjustment, but there is evidence that postreceptoral processes also exist. To investigate the latter, we pharmacologically mimicked the effects of light stimulation on mouse On bipolar cells, thus avoiding confounding effects of receptoral mechanisms. Here, we report that cGMP selectively enhances responses to dim, but not bright, stimuli through a purely postsynaptic mechanism. This action of cGMP was completely blocked by inhibitors of cGMP-dependent kinase. We propose that cGMP-dependent kinase decreases coupling of the On bipolar cell glutamate receptor to the downstream cascade, thus amplifying small decreases in photoreceptor transmitter levels that would otherwise go undetected by the visual system.

Key words: retina; On bipolar cell; G-protein-coupled receptor; cGK; mGluR6; PKG

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Received April 19, 2004; revised June 11, 2004; accepted June 14, 2004.

This article has been cited by other articles:

				Y. Nakajima, M. Moriyama, M. Hattori, N. Minato, and S. Nakanishi Isolation of ON Bipolar Cell Genes via hrGFP-coupled Cell Enrichment Using the mGluR6 Promoter J. Biochem., June 1, 2009; 145(6): 811 - 818. [Abstract] [Full Text] [PDF]

				J. Snellman, D. Zenisek, and S. Nawy Switching between transient and sustained signalling at the rod bipolar-AII amacrine cell synapse of the mouse retina J. Physiol., June 1, 2009; 587(11): 2443 - 2455. [Abstract] [Full Text] [PDF]

				Y. Shen, J. A. Heimel, M. Kamermans, N. S. Peachey, R. G. Gregg, and S. Nawy A Transient Receptor Potential-Like Channel Mediates Synaptic Transmission in Rod Bipolar Cells J. Neurosci., May 13, 2009; 29(19): 6088 - 6093. [Abstract] [Full Text] [PDF]

				D. Specht, S.-B. Wu, P. Turner, P. Dearden, F. Koentgen, U. Wolfrum, M. Maw, J. H. Brandstatter, and S. tom Dieck Effects of Presynaptic Mutations on a Postsynaptic Cacna1s Calcium Channel Colocalized with mGluR6 at Mouse Photoreceptor Ribbon Synapses Invest. Ophthalmol. Vis. Sci., February 1, 2009; 50(2): 505 - 515. [Abstract] [Full Text] [PDF]

				Y. Ping, H. Huang, X.-J. Zhang, and X.-L. Yang Melatonin potentiates rod signals to ON type bipolar cells in fish retina J. Physiol., June 1, 2008; 586(11): 2683 - 2694. [Abstract] [Full Text] [PDF]

				I. Panfoli, S. Ravera, A. Fabiano, R. Magrassi, A. Diaspro, A. Morelli, and I. M. Pepe Localization of the Cyclic ADP-Ribose-Dependent Calcium Signaling Pathway in Bovine Rod Outer Segments Invest. Ophthalmol. Vis. Sci., March 1, 2007; 48(3): 978 - 984. [Abstract] [Full Text] [PDF]

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