QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, July 21, 2004, 24(29):6621-6628; doi:10.1523/JNEUROSCI.1474-04.2004

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (12) Citing Articles via Google Scholar Google Scholar Articles by Snellman, J. Articles by Nawy, S. Search for Related Content PubMed PubMed Citation Articles by Snellman, J. Articles by Nawy, S.

 Previous Article  |  Next Article 

Cellular/Molecular
cGMP-Dependent Kinase Regulates Response Sensitivity of the Mouse On Bipolar Cell

Josefin Snellman¹ and Scott Nawy^1,2

Departments of ¹Neuroscience and ²Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, The Rose F. Kennedy Center, Bronx, New York 10461

The visual system can adjust its sensitivity over a wide range of light intensities. Photoreceptors account for some of this adjustment, but there is evidence that postreceptoral processes also exist. To investigate the latter, we pharmacologically mimicked the effects of light stimulation on mouse On bipolar cells, thus avoiding confounding effects of receptoral mechanisms. Here, we report that cGMP selectively enhances responses to dim, but not bright, stimuli through a purely postsynaptic mechanism. This action of cGMP was completely blocked by inhibitors of cGMP-dependent kinase. We propose that cGMP-dependent kinase decreases coupling of the On bipolar cell glutamate receptor to the downstream cascade, thus amplifying small decreases in photoreceptor transmitter levels that would otherwise go undetected by the visual system.

Key words: retina; On bipolar cell; G-protein-coupled receptor; cGK; mGluR6; PKG

---

Received April 19, 2004; revised June 11, 2004; accepted June 14, 2004.

This article has been cited by other articles:

				Y. Ping, H. Huang, X.-J. Zhang, and X.-L. Yang Melatonin potentiates rod signals to ON type bipolar cells in fish retina J. Physiol., June 1, 2008; 586(11): 2683 - 2694. [Abstract] [Full Text] [PDF]

				I. Panfoli, S. Ravera, A. Fabiano, R. Magrassi, A. Diaspro, A. Morelli, and I. M. Pepe Localization of the Cyclic ADP-Ribose-Dependent Calcium Signaling Pathway in Bovine Rod Outer Segments Invest. Ophthalmol. Vis. Sci., March 1, 2007; 48(3): 978 - 984. [Abstract] [Full Text] [PDF]

				S. Schein and K. M. Ahmad Efficiency of Synaptic Transmission of Single-Photon Events from Rod Photoreceptor to Rod Bipolar Dendrite Biophys. J., November 1, 2006; 91(9): 3257 - 3267. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help