 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
The Journal of Neuroscience, July 28, 2004, 24(30):6676-6685; doi:10.1523/JNEUROSCI.1367-04.2004
Previous Article | Next Article
Cellular/Molecular
External Tufted Cells: A Major Excitatory Element That Coordinates Glomerular Activity
Abdallah Hayar, Sergei Karnup, Matthew Ennis, andMichael T. Shipley Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201
The glomeruli of the olfactory bulb are the first site of synaptic processing in the olfactory system. The glomeruli contain three types of neurons that are referred to collectively as juxtaglomerular (JG) cells: external tufted (ET), periglomerular (PG), and short axon (SA) cells. JG cells are thought to interact synaptically, but little is known about the circuitry linking these neurons or their functional roles in olfactory processing. Single and paired whole-cell recordings were performed to investigate these questions. ET cells spontaneously fired rhythmic spike bursts in the theta frequency range and received monosynaptic olfactory nerve (ON) input. In contrast, all SA and most PG cells lacked monosynaptic ON input. PG and SA cells exhibited spontaneous, intermittent bursts of EPSCs that were highly correlated with spike bursts of ET cells in the same but not in different glomeruli. Paired recording experiments demonstrated that ET cells provide monosynaptic excitatory input to PG/SA cells; the ET to PG/SA cell synapse is mediated by glutamate. ET cells thus are a major excitatory linkage between ON input and other JG cells. Spontaneous bursting is highly correlated among ET cells of the same glomerulus, and ET cell activity remains correlated when all fast synaptic activity is blocked. The findings suggest that multiple, synchronously active ET cells synaptically converge onto single PG/SA cells. Synchronous ET cell bursting may function to amplify transient sensory input and coordinate glomerular output.
Key words: external tufted; bursting; dual recordings; coefficient of correlation; monosynaptic; synchrony
Received April 12, 2004; revised June 14, 2004; accepted June 14, 2004.
This article has been cited by other articles:
D. H. Gire and N. E. Schoppa
Control of On/Off Glomerular Signaling by a Local GABAergic Microcircuit in the Olfactory Bulb
J. Neurosci., October 28, 2009; 29(43): 13454 - 13464.
[Abstract] [Full Text] [PDF]
Q. Yuan
Theta bursts in the olfactory nerve paired with {beta}-adrenoceptor activation induce calcium elevation in mitral cells: A mechanism for odor preference learning in the neonate rat
Learn. Mem., October 26, 2009; 16(11): 676 - 681.
[Abstract] [Full Text] [PDF]
H.-W. Dong, A. Hayar, J. Callaway, X.-H. Yang, Q. Nai, and M. Ennis
Group I mGluR Activation Enhances Ca2+-Dependent Nonselective Cation Currents and Rhythmic Bursting in Main Olfactory Bulb External Tufted Cells
J. Neurosci., September 23, 2009; 29(38): 11943 - 11953.
[Abstract] [Full Text] [PDF]
Z. Shao, A. C. Puche, E. Kiyokage, G. Szabo, and M. T. Shipley
Two GABAergic Intraglomerular Circuits Differentially Regulate Tonic and Phasic Presynaptic Inhibition of Olfactory Nerve Terminals
J Neurophysiol, April 1, 2009; 101(4): 1988 - 2001.
[Abstract] [Full Text] [PDF]
D. De Saint Jan, D. Hirnet, G. L. Westbrook, and S. Charpak
External Tufted Cells Drive the Output of Olfactory Bulb Glomeruli
J. Neurosci., February 18, 2009; 29(7): 2043 - 2052.
[Abstract] [Full Text] [PDF]
Y. Livneh, N. Feinstein, M. Klein, and A. Mizrahi
Sensory Input Enhances Synaptogenesis of Adult-Born Neurons
J. Neurosci., January 7, 2009; 29(1): 86 - 97.
[Abstract] [Full Text] [PDF]
S. Liu and M. T. Shipley
Intrinsic Conductances Actively Shape Excitatory and Inhibitory Postsynaptic Responses in Olfactory Bulb External Tufted Cells
J. Neurosci., October 8, 2008; 28(41): 10311 - 10322.
[Abstract] [Full Text] [PDF]
Z. Zhou and L. Belluscio
Intrabulbar Projecting External Tufted Cells Mediate a Timing-Based Mechanism That Dynamically Gates Olfactory Bulb Output
J. Neurosci., October 1, 2008; 28(40): 9920 - 9928.
[Abstract] [Full Text] [PDF]
N. Pirez and M. Wachowiak
In Vivo Modulation of Sensory Input to the Olfactory Bulb by Tonic and Activity-Dependent Presynaptic Inhibition of Receptor Neurons
J. Neurosci., June 18, 2008; 28(25): 6360 - 6371.
[Abstract] [Full Text] [PDF]
D. O. Pimentel and T. W. Margrie
Glutamatergic transmission and plasticity between olfactory bulb mitral cells
J. Physiol., April 15, 2008; 586(8): 2107 - 2119.
[Abstract] [Full Text] [PDF]
M. S. Grubb, A. Nissant, K. Murray, and P.-M. Lledo
Functional Maturation of the First Synapse in Olfaction: Development and Adult Neurogenesis
J. Neurosci., March 12, 2008; 28(11): 2919 - 2932.
[Abstract] [Full Text] [PDF]
S. Liu and M. T. Shipley
Multiple Conductances Cooperatively Regulate Spontaneous Bursting in Mouse Olfactory Bulb External Tufted Cells
J. Neurosci., February 13, 2008; 28(7): 1625 - 1639.
[Abstract] [Full Text] [PDF]
N. Karpuk and A. Hayar
Activation of Postsynaptic GABAB Receptors Modulates the Bursting Pattern and Synaptic Activity of Olfactory Bulb Juxtaglomerular Neurons
J Neurophysiol, January 1, 2008; 99(1): 308 - 319.
[Abstract] [Full Text] [PDF]
W. J. Tyler, G. C. Petzold, S. K. Pal, and V. N. Murthy
Experience-Dependent Modification of Primary Sensory Synapses in the Mammalian Olfactory Bulb
J. Neurosci., August 29, 2007; 27(35): 9427 - 9438.
[Abstract] [Full Text] [PDF]
A. Hayar and M. Ennis
Endogenous GABA and Glutamate Finely Tune the Bursting of Olfactory Bulb External Tufted Cells
J Neurophysiol, August 1, 2007; 98(2): 1052 - 1056.
[Abstract] [Full Text] [PDF]
H.-W. Dong, A. Hayar, and M. Ennis
Activation of Group I Metabotropic Glutamate Receptors on Main Olfactory Bulb Granule Cells and Periglomerular Cells Enhances Synaptic Inhibition of Mitral Cells
J. Neurosci., May 23, 2007; 27(21): 5654 - 5663.
[Abstract] [Full Text] [PDF]
T. A. Cleland, B. A. Johnson, M. Leon, and C. Linster
Relational representation in the olfactory system
PNAS, February 6, 2007; 104(6): 1953 - 1958.
[Abstract] [Full Text] [PDF]
Y. V. Bobkov and B. W. Ache
Intrinsically Bursting Olfactory Receptor Neurons
J Neurophysiol, February 1, 2007; 97(2): 1052 - 1057.
[Abstract] [Full Text] [PDF]
D. De Saint Jan and G. L. Westbrook
Disynaptic Amplification of Metabotropic Glutamate Receptor 1 Responses in the Olfactory Bulb
J. Neurosci., January 3, 2007; 27(1): 132 - 140.
[Abstract] [Full Text] [PDF]
Z. Zhou, W. Xiong, A. V. Masurkar, W. R. Chen, and G. M. Shepherd
Dendritic Calcium Plateau Potentials Modulate Input-Output Properties of Juxtaglomerular Cells in the Rat Olfactory Bulb
J Neurophysiol, November 1, 2006; 96(5): 2354 - 2363.
[Abstract] [Full Text] [PDF]
Q. Yuan and T. Knopfel
Olfactory Nerve Stimulation-Induced Calcium Signaling in the Mitral Cell Distal Dendritic Tuft
J Neurophysiol, April 1, 2006; 95(4): 2417 - 2426.
[Abstract] [Full Text] [PDF]
M. Ennis, M. Zhu, T. Heinbockel, and A. Hayar
Olfactory Nerve-Evoked, Metabotropic Glutamate Receptor-Mediated Synaptic Responses in Rat Olfactory Bulb Mitral Cells
J Neurophysiol, April 1, 2006; 95(4): 2233 - 2241.
[Abstract] [Full Text] [PDF]
A. Gelperin
Olfactory Computations and Network Oscillation
J. Neurosci., February 8, 2006; 26(6): 1663 - 1668.
[Full Text] [PDF]
N. Buonviso, C. Amat, and P. Litaudon
Respiratory Modulation of Olfactory Neurons in the Rodent Brain
Chem Senses, February 1, 2006; 31(2): 145 - 154.
[Abstract] [Full Text] [PDF]
A. Kepecs, N. Uchida, and Z. F. Mainen
The Sniff as a Unit of Olfactory Processing
Chem Senses, February 1, 2006; 31(2): 167 - 179.
[Abstract] [Full Text] [PDF]
T. A. Cleland and C. Linster
Computation in the Olfactory System
Chem Senses, November 1, 2005; 30(9): 801 - 813.
[Abstract] [Full Text] [PDF]
M. Wachowiak, J. P. McGann, P. M. Heyward, Z. Shao, A. C. Puche, and M. T. Shipley
Inhibition of Olfactory Receptor Neuron Input to Olfactory Bulb Glomeruli Mediated by Suppression of Presynaptic Calcium Influx
J Neurophysiol, October 1, 2005; 94(4): 2700 - 2712.
[Abstract] [Full Text] [PDF]
A. Hayar, M. T. Shipley, and M. Ennis
Olfactory Bulb External Tufted Cells Are Synchronized by Multiple Intraglomerular Mechanisms
J. Neurosci., September 7, 2005; 25(36): 8197 - 8208.
[Abstract] [Full Text] [PDF]
D. De Saint Jan and G. L. Westbrook
Detecting Activity in Olfactory Bulb Glomeruli with Astrocyte Recording
J. Neurosci., March 16, 2005; 25(11): 2917 - 2924.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|