QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, August 4, 2004, 24(31):7015-7023; doi:10.1523/JNEUROSCI.5492-03.2004

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (31) Citing Articles via Google Scholar Google Scholar Articles by Moita, M. A. P. Articles by Blair, H. T. Search for Related Content PubMed PubMed Citation Articles by Moita, M. A. P. Articles by Blair, H. T.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Putting Fear in Its Place: Remapping of Hippocampal Place Cells during Fear Conditioning

Marta A. P. Moita,¹ Svetlana Rosis,² Yu Zhou,² Joseph E. LeDoux,² and Hugh T. Blair³

¹Instituto Gulbenkian de Sciencia, P-2780-156 Oeiras, Portugal, ²Center for Neural Science, New York University, New York, New York 10003, and ³Psychology Department, University of California, Los Angeles, California 90095

We recorded hippocampal place cells in two spatial environments: a training environment in which rats underwent fear conditioning and a neutral control environment. Fear conditioning caused many place cells to alter (or remap) their preferred firing locations in the training environment, whereas most cells remained stable in the control environment. This finding indicates that aversive reinforcement can induce place cell remapping even when the environment itself remains unchanged. Furthermore, contextual fear conditioning caused significantly more remapping of place cells than auditory fear conditioning, suggesting that place cell remapping was related to the rat's learned fear of the environment. These results suggest that one possible function of place cell remapping may be to generate new spatial representations of a single environment, which could help the animal to discriminate among different motivational contexts within that environment.

Key words: activity; aversion; CA1; conditioned (conditioning); extracellular; hippocampus; learning

---

Received Dec 13, 2003; revised May 28, 2004; accepted June 3, 2004.

This article has been cited by other articles:

				P. J. Kennedy and M. L. Shapiro Motivational states activate distinct hippocampal representations to guide goal-directed behaviors PNAS, June 30, 2009; 106(26): 10805 - 10810. [Abstract] [Full Text] [PDF]

				N. Matsuo, L. Reijmers, and M. Mayford Spine-Type-Specific Recruitment of Newly Synthesized AMPA Receptors with Learning Science, February 22, 2008; 319(5866): 1104 - 1107. [Abstract] [Full Text] [PDF]

				S. Leutgeb and J. K. Leutgeb Pattern separation, pattern completion, and new neuronal codes within a continuous CA3 map Learn. Mem., November 15, 2007; 14(11): 745 - 757. [Abstract] [Full Text] [PDF]

				T. J. McHugh, M. W. Jones, J. J. Quinn, N. Balthasar, R. Coppari, J. K. Elmquist, B. B. Lowell, M. S. Fanselow, M. A. Wilson, and S. Tonegawa Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network Science, July 6, 2007; 317(5834): 94 - 99. [Abstract] [Full Text] [PDF]

				H. T. Blair, A. C. Welday, and K. Zhang Scale-Invariant Memory Representations Emerge from Moire Interference between Grid Fields That Produce Theta Oscillations: A Computational Model J. Neurosci., March 21, 2007; 27(12): 3211 - 3229. [Abstract] [Full Text] [PDF]

				D. M. Smith and S. J. Y. Mizumori Learning-related development of context-specific neuronal responses to places and events: the hippocampal role in context processing. J. Neurosci., March 22, 2006; 26(12): 3154 - 3163. [Abstract] [Full Text] [PDF]

				S. Leutgeb, J. K. Leutgeb, C. A. Barnes, E. I. Moser, B. L. McNaughton, and M.-B. Moser Independent Codes for Spatial and Episodic Memory in Hippocampal Neuronal Ensembles Science, July 22, 2005; 309(5734): 619 - 623. [Abstract] [Full Text] [PDF]

				J. W. Kasckow, T. M. Segar, C. Xiao, A. R. Furay, N. K. Evanson, M. M. Ostrander, and J. P. Herman Stability of Neuroendocrine and Behavioral Responsiveness in Aging Fischer 344/Brown-Norway Hybrid Rats Endocrinology, July 1, 2005; 146(7): 3105 - 3112. [Abstract] [Full Text] [PDF]

				M. Ohno, W. Tseng, A. J. Silva, and J. F. Disterhoft Trace eyeblink conditioning requires the hippocampus but not autophosphorylation of {alpha}CaMKII in mice Learn. Mem., May 1, 2005; 12(3): 211 - 215. [Abstract] [Full Text] [PDF]

				H. T. Blair, V. K. Huynh, V. T. Vaz, J. Van, R. R. Patel, A. K. Hiteshi, J. E. Lee, and J. W. Tarpley Unilateral Storage of Fear Memories by the Amygdala J. Neurosci., April 20, 2005; 25(16): 4198 - 4205. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help