QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, August 25, 2004, 24(34):7455-7463; doi:10.1523/JNEUROSCI.1840-04.2004

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (21) Citing Articles via Google Scholar Google Scholar Articles by Wood, D. E. Articles by Nusbaum, M. P. Search for Related Content PubMed PubMed Citation Articles by Wood, D. E. Articles by Nusbaum, M. P.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Intercircuit Control via Rhythmic Regulation of Projection Neuron Activity

Debra E. Wood,^1,2 Yair Manor,³ Farzan Nadim,⁴ and Michael P. Nusbaum¹

¹Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6074, ²Department of Biology, Case Western Reserve University, Cleveland, Ohio 44106, ³Zlotowski Center for Neuroscience and Department of Life Science, Ben-Gurion University, BeerSheva 84105, Israel, and ⁴Department of Biological Sciences, Rutgers University, and Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, New Jersey 07102

Synaptic feedback from rhythmically active neuronal circuits commonly causes their descending inputs to exhibit the rhythmic activity pattern generated by that circuit. In most cases, however, the function of this rhythmic feedback is unknown. In fact, generally these inputs can still activate the target circuit when driven in a tonic activity pattern. We are using the crab stomatogastric nervous system (STNS) to test the hypothesis that the neuronal circuit-mediated rhythmic activity pattern in projection neurons contributes to intercircuit regulation. The crab STNS contains an identified projection neuron, modulatory commissural neuron 1 (MCN1), whose tonic stimulation activates and modulates the gastric mill (chewing) and pyloric (filtering of chewed food) motor circuits in the stomatogastric ganglion (STG). During tonic stimulation of MCN1, the pyloric circuit regulates both gastric mill cycle frequency and gastropyloric coordination via a direct synapse onto a gastric mill neuron in the STG. However, when MCN1 is spontaneously active, it has a pyloric-timed activity pattern attributable to synaptic input from the pyloric circuit. This pyloric-timed activity in MCN1 provides the pyloric circuit with a second pathway for regulating the gastric mill rhythm. At these times, the direct STG synapse from the pyloric circuit to the gastric mill circuit is not necessary for pyloric regulation of the gastric mill rhythm. However, in the intact system, these two pathways play complementary roles in this intercircuit regulation. Thus, one role for rhythmicity in modulatory projection neurons is to enable them to mediate the interactions between distinct but related neuronal circuits.

Key words: central pattern generator; neuromodulation; stomatogastric ganglion; pyloric circuit; gastric mill circuit; modulatory projection neuron

---

Received May 12, 2004; revised July 2, 2004; accepted July 3, 2004.

This article has been cited by other articles:

				Y. Zhang, O. Khorkova, R. Rodriguez, and J. Golowaschi Activity and Neuromodulatory Input Contribute to the Recovery of Rhythmic Output After Decentralization in a Central Pattern Generator J Neurophysiol, January 1, 2009; 101(1): 372 - 386. [Abstract] [Full Text] [PDF]

				D. M. Blitz and M. P. Nusbaum State-Dependent Presynaptic Inhibition Regulates Central Pattern Generator Feedback to Descending Inputs J. Neurosci., September 17, 2008; 28(38): 9564 - 9574. [Abstract] [Full Text] [PDF]

				N. Spitzer, G. Cymbalyuk, H. Zhang, D. H. Edwards, and D. J. Baro Serotonin Transduction Cascades Mediate Variable Changes in Pyloric Network Cycle Frequency in Response to the Same Modulatory Challenge J Neurophysiol, June 1, 2008; 99(6): 2844 - 2863. [Abstract] [Full Text] [PDF]

				A. K. Tryba, F. Pena, S. P. Lieske, J.-C. Viemari, M. Thoby-Brisson, and J.-M. Ramirez Differential Modulation of Neural Network and Pacemaker Activity Underlying Eupnea and Sigh-Breathing Activities J Neurophysiol, May 1, 2008; 99(5): 2114 - 2125. [Abstract] [Full Text] [PDF]

				D. M. Blitz, R. S. White, S. R. Saideman, A. Cook, A. E. Christie, F. Nadim, and M. P. Nusbaum A newly identified extrinsic input triggers a distinct gastric mill rhythm via activation of modulatory projection neurons J. Exp. Biol., March 15, 2008; 211(6): 1000 - 1011. [Abstract] [Full Text] [PDF]

				M. P. Beenhakker, M. S. Kirby, and M. P. Nusbaum Mechanosensory Gating of Proprioceptor Input to Modulatory Projection Neurons J. Neurosci., December 26, 2007; 27(52): 14308 - 14316. [Abstract] [Full Text] [PDF]

				M. S. Kirby and M. P. Nusbaum Peptide Hormone Modulation of a Neuronally Modulated Motor Circuit J Neurophysiol, December 1, 2007; 98(6): 3206 - 3220. [Abstract] [Full Text] [PDF]

				S. R. Saideman, D. M. Blitz, and M. P. Nusbaum Convergent Motor Patterns from Divergent Circuits J. Neurosci., June 20, 2007; 27(25): 6664 - 6674. [Abstract] [Full Text] [PDF]

				S. R. Saideman, M. Ma, K. K. Kutz-Naber, A. Cook, P. Torfs, L. Schoofs, L. Li, and M. P. Nusbaum Modulation of Rhythmic Motor Activity by Pyrokinin Peptides J Neurophysiol, January 1, 2007; 97(1): 579 - 595. [Abstract] [Full Text] [PDF]

				S. R. Saideman, A. E. Christie, P. Torfs, J. Huybrechts, L. Schoofs, and M. P. Nusbaum Actions of kinin peptides in the stomatogastric ganglion of the crab Cancer borealis J. Exp. Biol., September 15, 2006; 209(18): 3664 - 3676. [Abstract] [Full Text] [PDF]

				D. Bucher, A. L. Taylor, and E. Marder Central Pattern Generating Neurons Simultaneously Express Fast and Slow Rhythmic Activities in the Stomatogastric Ganglion J Neurophysiol, June 1, 2006; 95(6): 3617 - 3632. [Abstract] [Full Text] [PDF]

				D. I. Messinger, K. K. Kutz, T. Le, D. R. Verley, Y.-W. A. Hsu, C. T. Ngo, S. D. Cain, J. T. Birmingham, L. Li, and A. E. Christie Identification and characterization of a tachykinin-containing neuroendocrine organ in the commissural ganglion of the crab Cancer productus J. Exp. Biol., September 1, 2005; 208(17): 3303 - 3319. [Abstract] [Full Text] [PDF]

				D. M. Blitz, M. P. Beenhakker, and M. P. Nusbaum Different Sensory Systems Share Projection Neurons But Elicit Distinct Motor Patterns J. Neurosci., December 15, 2004; 24(50): 11381 - 11390. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help