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The Journal of Neuroscience, August 25, 2004, 24(34):7524-7530; doi:10.1523/JNEUROSCI.1395-04.2004

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Behavioral/Systems/Cognitive
Asymmetrical Neural Substrates of Tactile Discrimination in Humans: A Functional Magnetic Resonance Imaging Study

Tokiko Harada,^1,2 Daisuke N. Saito,² Ken-Ichi Kashikura,³ Tetsuhiro Sato,³ Yoshiharu Yonekura,³ Manabu Honda,¹ and Norihiro Sadato^1,2,4

¹Department of Physiological Sciences, The Graduate University for Advanced Studies (Sokendai), Kanagawa 240-0193, Japan, ²National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, Japan, ³Biomedical Imaging Research Center, Fukui Medical University, Fukui 910-1193, Japan, and ⁴Japan Science and Technology Corporation/Research Institute of Science and Technology for Society, Kawaguchi 332-0012, Japan

The left-hand advantage seen during tactile discrimination tasks suggests hemispheric-processing asymmetry, although its neural substrates are not well known. We used functional magnetic resonance imaging to evaluate the laterality of the neural substrates involved in tactile discrimination in 19 normal volunteers. Passive tactile discrimination tasks, along with appropriate control tasks, were performed with both the right and left hands to evaluate the effects of the hand used and hemispheric effects (i.e., laterality of the activation pattern). Regardless of the hand used, the right dorsolateral prefrontal cortex, posterior parietal cortex, pre-supplementary motor area, and rostral portion of the dorsal premotor cortex (PMdr) were activated asymmetrically during tactile discrimination. This confirms the previous finding of a right-sided asymmetry for tactile shape discrimination. Hand effects were found in the left caudal portion of PMd (PMdc) adjacent to the central sulcus, which showed prominent activation during right-handed but not left-handed discrimination tasks. This asymmetric activation in the left PMdc might be related to the asymmetric interhemispheric interaction during right-handed tactile discrimination.

Key words: dorsal premotor cortex (PMd); fMRI; interhemispheric transfer; spatial-attention network; tactile shape discrimination; blood flow

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Received April 14, 2004; revised July 14, 2004; accepted July 20, 2004.

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