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The Journal of Neuroscience, September 8, 2004, 24(36):7964-7977; doi:10.1523/JNEUROSCI.5102-03.2004

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Behavioral/Systems/Cognitive
Attentional Modulation of Motion Integration of Individual Neurons in the Middle Temporal Visual Area

Erik P. Cook and John H. R. Maunsell

Howard Hughes Medical Institute and Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030

We examined how spatially directed attention affected the integration of motion in neurons of the middle temporal (MT) area of visual cortex. We recorded from single MT neurons while monkeys performed a motion detection task under two attentional states. Using 0% coherent random dot motion, we estimated the optimal linear transfer function (or kernel) between the global motion and the neuronal response. This linear kernel filtered the random dot motion across direction, speed, and time. Slightly less than one-half of the neurons produced reasonably well defined kernels that also tended to account for both the directional selectivity and responses to coherent motion of different strengths. This subpopulation of cells had faster, more transient, and more robust responses to visual stimuli than neurons with kernels that did not contain well defined regions of integration. For those neurons that had large attentional modulation and produced well defined kernels, we found attention scaled the temporal profile of the transfer function with no appreciable shift in time or change in shape. Thus, for MT neurons described by a linear transfer function, attention produced a multiplicative scaling of the temporal integration window.

Key words: attention; vision; MT; motion; macaque monkey; reverse correlation

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Received Nov 18, 2003; revised July 28, 2004; accepted July 28, 2004.

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