 |
||||
|
||||
|
||||
|
||||
|
||||
The Journal of Neuroscience, September 29, 2004, 24(39):8621-8628; doi:10.1523/JNEUROSCI.3280-04.2004
Previous Article | Next Article
Cellular/Molecular
Dopamine Excites Nucleus Accumbens Neurons through the Differential Modulation of Glutamate and GABA Release
Gregory O. Hjelmstad Department of Neurology, Wheeler Center for the Neurobiology of Addiction and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California 94608
Afferent activity into the nucleus accumbens (NAc) occurs in bursts of action potentials. However, it is unclear how synapses in this nucleus respond to such bursts, or how these responses are altered by dopamine (DA). I examined the effects of DA on excitatory and inhibitory responses to trains of stimuli in rat NAc slices. Both EPSCs and IPSCs showed use-dependent depression during trains. Although DA inhibited both glutamate and GABA release in the NAc, it differentially inhibited release during trains. The inhibition of IPSCs persisted throughout the train of stimuli, whereas the inhibition of EPSCs progressively diminished. This differential modulation may be explained by a calcium-dependent change in the recovery from depression at the GABA synapses, where DA acts by decreasing Ca2+ entry. Thus, at later stages of sustained stimulation, DA preferentially inhibits GABA release, producing a net excitatory effect during bursts suggesting a mechanism for enhancing the contrast between competing inputs into the NAc, as well as for affecting long-term plasticity in this structure.
Key words: accumbens; dopamine; depression; burst; presynaptic; calcium
Received June 9, 2004; revised August 24, 2004; accepted August 24, 2004.
This article has been cited by other articles:
A. Ishikawa, F. Ambroggi, S. M. Nicola, and H. L. Fields
Dorsomedial Prefrontal Cortex Contribution to Behavioral and Nucleus Accumbens Neuronal Responses to Incentive Cues
J. Neurosci., May 7, 2008; 28(19): 5088 - 5098.
[Abstract] [Full Text] [PDF]
J. Baufreton and M. D. Bevan
D2-like dopamine receptor-mediated modulation of activity-dependent plasticity at GABAergic synapses in the subthalamic nucleus
J. Physiol., April 15, 2008; 586(8): 2121 - 2142.
[Abstract] [Full Text] [PDF]
J. T. Moyer, J. A. Wolf, and L. H. Finkel
Effects of Dopaminergic Modulation on the Integrative Properties of the Ventral Striatal Medium Spiny Neuron
J Neurophysiol, December 1, 2007; 98(6): 3731 - 3748.
[Abstract] [Full Text] [PDF]
P. Han, S. T. Nakanishi, M. A. Tran, and P. J. Whelan
Dopaminergic Modulation of Spinal Neuronal Excitability
J. Neurosci., November 28, 2007; 27(48): 13192 - 13204.
[Abstract] [Full Text] [PDF]
F. Tecuapetla, L. Carrillo-Reid, J. Bargas, and E. Galarraga
Dopaminergic modulation of short-term synaptic plasticity at striatal inhibitory synapses
PNAS, June 12, 2007; 104(24): 10258 - 10263.
[Abstract] [Full Text] [PDF]
G. O. Hjelmstad
Interactions Between Asynchronous Release and Short-Term Plasticity in the Nucleus Accumbens Slice
J Neurophysiol, March 1, 2006; 95(3): 2020 - 2023.
[Abstract] [Full Text] [PDF]
G. Gonzalez-Burgos, S. Kroener, J. K. Seamans, D. A. Lewis, and G. Barrionuevo
Dopaminergic Modulation of Short-Term Synaptic Plasticity in Fast-Spiking Interneurons of Primate Dorsolateral Prefrontal Cortex
J Neurophysiol, December 1, 2005; 94(6): 4168 - 4177.
[Abstract] [Full Text] [PDF]
G. A. Phares and J. H. Byrne
Analysis of 5-HT-Induced Short-Term Facilitation at Aplysia Sensorimotor Synapse During Bursts: Increased Synaptic Gain That Does Not Require ERK Activation
J Neurophysiol, July 1, 2005; 94(1): 871 - 877.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|