QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, October 6, 2004, 24(40):8823-8828; doi:10.1523/JNEUROSCI.4542-03.2004

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (23) Citing Articles via Google Scholar Google Scholar Articles by Perazzona, B. Articles by Davis, R. L. Search for Related Content PubMed PubMed Citation Articles by Perazzona, B. Articles by Davis, R. L.

 Previous Article  |  Next Article 

BRIEF COMMUNICATION
The Role of cAMP Response Element-Binding Protein in Drosophila Long-Term Memory

Bastianella Perazzona,^1 * Guillaume Isabel,^3 * Thomas Preat,³ and Ronald L. Davis^1,2

Departments of ¹Molecular and Cellular Biology and ²Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas 77030, and ³Developpement, Evolution, Plasticite du Systeme Nerveux, Centre National de la Recherche Scientifique, 91190 Gif-sur-Yvette, France

In Drosophila, the transcription factor cAMP response element-binding protein 2 (dCREB2) has been reported to modulate the formation of long-term olfactory memory (LTM). Overexpression of a repressor isoform of CREB (dCREB2-b) under the control of a heat-shock promoter was reported to block LTM, whereas overexpression of an activator isoform (dCREB2-a) was reported to enhance LTM. A ratiometric model based on these results predicts that the balance of functional dCREB2-a and dCREB2-b provides a switch for memories to remain labile or to become enduring. We show here that the dCREB2-a transgene originally reported to enhance LTM carries a mutation that produces a translational reading-frame shift with the consequent formation of a stop codon at predicted amino acid position 79. Overexpression of this mutant dCREB2-a transgene or a corrected dCREB2-a transgene failed to show any enhancement of LTM. Overexpression of the dCREB2-b repressor transgene, in contrast, produced the anticipated block in LTM formation. We discuss the implications of these findings and propose an alternative model for the role of dCREB in Drosophila LTM.

Key words: Drosophila; CREB; learning; memory; olfactory conditioning; behaviors

---

Received Oct 6, 2003; revised July 23, 2004; accepted July 23, 2004.

This article has been cited by other articles:

				M. J. Krashes and S. Waddell Rapid Consolidation to a radish and Protein Synthesis-Dependent Long-Term Memory after Single-Session Appetitive Olfactory Conditioning in Drosophila J. Neurosci., March 19, 2008; 28(12): 3103 - 3113. [Abstract] [Full Text] [PDF]

				T. Farooqui Octopamine-Mediated Neuronal Plasticity in Honeybees: Implications for Olfactory Dysfunction in Humans Neuroscientist, August 1, 2007; 13(4): 304 - 322. [Abstract] [PDF]

				M. H. Milekic, G. Pollonini, and C. M. Alberini Temporal requirement of C/EBP{beta} in the amygdala following reactivation but not acquisition of inhibitory avoidance Learn. Mem., July 18, 2007; 14(7): 504 - 511. [Abstract] [Full Text] [PDF]

				J. J. Brightwell, C. A. Smith, R. L. Neve, and P. J. Colombo Long-term memory for place learning is facilitated by expression of cAMP response element-binding protein in the dorsal hippocampus Learn. Mem., March 8, 2007; 14(3): 195 - 199. [Abstract] [Full Text] [PDF]

				R. D. Hawkins, E. R. Kandel, and C. H. Bailey Molecular Mechanisms of Memory Storage in Aplysia Biol. Bull., June 1, 2006; 210(3): 174 - 191. [Abstract] [Full Text] [PDF]

				J. Collatz, C. Muller, and J. L.M. Steidle Protein synthesis-dependent long-term memory induced by one single associative training trial in the parasitic wasp Lariophagus distinguendus. Learn. Mem., May 1, 2006; 13(3): 263 - 266. [Abstract] [Full Text] [PDF]

				K. Parvez, O. Stewart, S. Sangha, and K. Lukowiak Boosting intermediate-term into long-term memory J. Exp. Biol., April 15, 2005; 208(8): 1525 - 1536. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help