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The Journal of Neuroscience, November 3, 2004, 24(44):9745-9751; doi:10.1523/JNEUROSCI.3211-04.2004

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Behavioral/Systems/Cognitive
The S6KII (rsk) Gene of Drosophila melanogaster Differentially Affects an Operant and a Classical Learning Task

Gabriele Putz,¹ Franco Bertolucci,¹ Thomas Raabe,² Troy Zars,¹ and Martin Heisenberg¹

¹Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Am Hubland, D-97074 Wuerzburg, Germany, and ²Institut für Medizinische Strahlenkunde und Zellforschung, D-97078 Wuerzburg, Germany

In an attempt to dissect classical and operant conditioning in Drosophila melanogaster, we have isolated the gene for ribosomal S6 kinase II (S6KII). This enzyme is part of a family of serine-threonine kinases that in mammals have been implicated in the MAPK (mitogen-activated protein kinase) signaling cascade controlling (among other processes) synaptic plasticity (long-term potentiation/long-term depression) and memory formation. The human homolog rsk2 has been linked to mental retardation (Coffin-Lowry syndrome). Mutant analysis in Drosophila shows that S6KII serves different functions in operant place learning and classical (pavlovian) olfactory conditioning. Whereas in the null mutant only pavlovian olfactory learning is affected, a P-element insertion mutant reducing the amount of S6KII only affects operant place learning. A mutant lacking part of the N-terminal kinase domain and performing poorly in both learning tasks is dominant in the operant paradigm and recessive in the pavlovian paradigm. The behavioral defects in the pavlovian task can be rescued by the genomic S6KII transgene. Overexpression of S6KII in wild type has a dominant-negative effect on the operant task that is rescued by the null mutant, whereas in the pavlovian task overexpression may even enhance learning performance.

Key words: Drosophila melanogaster; associative learning; heat box; operant conditioning; classical conditioning; p90 ribosomal S6 kinase

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Received July 6, 2004; revised September 8, 2004; accepted September 13, 2004.

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