 |
||||
|
||||
|
||||
|
||||
|
||||
The Journal of Neuroscience, November 3, 2004, 24(44):9847-9861; doi:10.1523/JNEUROSCI.0738-04.2004
Previous Article | Next Article
Cellular/Molecular
The Kinetic Profile of Intracellular Calcium Predicts Long-Term Potentiation and Long-Term Depression
Iskander Ismailov,1 Djanenkhodja Kalikulov,1 Takafumi Inoue,3 andMichael J. Friedlander1,2 1Department of Neurobiology and the Civitan International Research Center and 2The Evelyn F. McKnight Brain Institute, The University of Alabama at Birmingham, Birmingham, Alabama 35294, and 3Department of Molecular Neurobiology, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
Efficiency of synaptic transmission within the neocortex is regulated throughout life by experience and activity. Periods of correlated or uncorrelated presynaptic and postsynaptic activity lead to enduring changes in synaptic efficiency [long-term potentiation (LTP) and long-term depression (LTD), respectively]. The initial plasticity triggering event is thought to be a precipitous rise in postsynaptic intracellular calcium, with higher levels inducing LTP and more moderate levels inducing LTD. We used a pairing protocol in visual cortical brain slices from young guinea pigs with whole-cell recording and calcium imaging to compare the kinetic profiles of calcium signals generated in response to individual pairings along with the cumulative calcium wave and plasticity outcome. The identical pairing protocol applied to layer 2/3 pyramidal neurons results in different plasticity outcomes between cells. These differences are not attributable to variations in the conditioning protocol, cellular properties, inter-animal variability, animal age, differences in spike timing between the synaptic response and spikes, washout of plasticity factors, recruitment of inhibition, or activation of different afferents. The different plasticity outcomes are reliably predicted by individual intracellular calcium transients in the dendrites after the first few pairings. In addition to the differences in the individual calcium transients, the cumulative calcium wave that spreads to the soma also has a different profile for cells that undergo LTP versus LTD. We conclude that there are biological differences between like-type cells in the dendritic calcium signals generated by coincident synaptic input and spiking that determine the sign of the plasticity response after brief associations.
Key words: cortex; imaging; calcium; synaptic plasticity; LTP; LTD; pairing
Received March 1, 2004; revised September 21, 2004; accepted September 22, 2004.
This article has been cited by other articles:
P. McCoy, T. T. Norton, and L. L. McMahon
Layer 2/3 Synapses in Monocular and Binocular Regions of Tree Shrew Visual Cortex Express mAChR-Dependent Long-Term Depression and Long-Term Potentiation
J Neurophysiol, July 1, 2008; 100(1): 336 - 345.
[Abstract] [Full Text] [PDF]
G. Barriere, M. Tartas, J.-R. Cazalets, and S. S. Bertrand
Interplay between neuromodulator-induced switching of short-term plasticity at sensorimotor synapses in the neonatal rat spinal cord
J. Physiol., April 1, 2008; 586(7): 1903 - 1920.
[Abstract] [Full Text] [PDF]
M. A. Farries and A. L. Fairhall
Reinforcement Learning With Modulated Spike Timing Dependent Synaptic Plasticity
J Neurophysiol, December 1, 2007; 98(6): 3648 - 3665.
[Abstract] [Full Text] [PDF]
K. A. Buchanan and J. R. Mellor
The development of synaptic plasticity induction rules and the requirement for postsynaptic spikes in rat hippocampal CA1 pyramidal neurones
J. Physiol., December 1, 2007; 585(2): 429 - 445.
[Abstract] [Full Text] [PDF]
J. L. Hellier, D. R. Grosshans, S. J. Coultrap, J. P. Jones, P. Dobelis, M. D. Browning, and K. J. Staley
NMDA Receptor Trafficking at Recurrent Synapses Stabilizes the State of the CA3 Network
J Neurophysiol, November 1, 2007; 98(5): 2818 - 2826.
[Abstract] [Full Text] [PDF]
P. A. McCoy and L. L. McMahon
Muscarinic Receptor Dependent Long-Term Depression in Rat Visual Cortex Is PKC Independent but Requires ERK1/2 Activation and Protein Synthesis
J Neurophysiol, October 1, 2007; 98(4): 1862 - 1870.
[Abstract] [Full Text] [PDF]
J. Torres-Reveron and M. J. Friedlander
Properties of Persistent Postnatal Cortical Subplate Neurons
J. Neurosci., September 12, 2007; 27(37): 9962 - 9974.
[Abstract] [Full Text] [PDF]
N. R. Hardingham, G. E. Hardingham, K. D. Fox, and J. J. B. Jack
Presynaptic Efficacy Directs Normalization of Synaptic Strength in Layer 2/3 Rat Neocortex After Paired Activity
J Neurophysiol, April 1, 2007; 97(4): 2965 - 2975.
[Abstract] [Full Text] [PDF]
T. Nevian and B. Sakmann
Spine Ca2+ Signaling in Spike-Timing-Dependent Plasticity
J. Neurosci., October 25, 2006; 26(43): 11001 - 11013.
[Abstract] [Full Text] [PDF]
H. Ikeda, J. Stark, H. Fischer, M. Wagner, R. Drdla, T. Jager, and J. Sandkuhler
Synaptic amplifier of inflammatory pain in the spinal dorsal horn.
Science, June 16, 2006; 312(5780): 1659 - 1662.
[Abstract] [Full Text] [PDF]
J. D. King Jr. and S. D. Meriney
Proportion of N-Type Calcium Current Activated by Action Potential Stimuli
J Neurophysiol, December 1, 2005; 94(6): 3762 - 3770.
[Abstract] [Full Text] [PDF]
G. Popescu
Principles of N-Methyl-D-aspartate Receptor Allosteric Modulation
Mol. Pharmacol., October 1, 2005; 68(4): 1148 - 1155.
[Abstract] [Full Text] [PDF]
J. E. Rubin, R. C. Gerkin, G.-Q. Bi, and C. C. Chow
Calcium Time Course as a Signal for Spike-Timing-Dependent Plasticity
J Neurophysiol, May 1, 2005; 93(5): 2600 - 2613.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|