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The Journal of Neuroscience, November 3, 2004, 24(44):9862-9869; doi:10.1523/JNEUROSCI.3446-04.2004

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Behavioral/Systems/Cognitive
Deletion of N-Type Calcium Channels Alters Ethanol Reward and Reduces Ethanol Consumption in Mice

Philip M. Newton,¹ Christine J. Orr,¹ Melisa J. Wallace,¹ Chanki Kim,² Hee-Sup Shin,² and Robert O. Messing¹

¹Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, and ²Center for Calcium and Learning, Korea Institute of Science and Technology, 136-791 Seoul, Republic of Korea

N-type calcium channels are modulated by acute and chronic ethanol exposure in vitro at concentrations known to affect humans, but it is not known whether N-type channels are important for behavioral responses to ethanol in vivo. Here, we show that in mice lacking functional N-type calcium channels, voluntary ethanol consumption is reduced and place preference is developed only at a low dose of ethanol. The hypnotic effects of ethanol are also substantially diminished, whereas ethanol-induced ataxia is mildly increased. These results demonstrate that N-type calcium channels modulate acute responses to ethanol and are important mediators of ethanol reward and preference.

Key words: alcoholism; calcium channel; conotoxin; conditioned place preference; ethanol preference; knock-out

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Received May 21, 2004; revised September 23, 2004; accepted September 24, 2004.

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