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The Journal of Neuroscience, November 10, 2004, 24(45):10099-10102; doi:10.1523/JNEUROSCI.2680-04.2004
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The Brain-Derived Neurotrophic Factor val66met Polymorphism and Variation in Human Cortical Morphology
Lukas Pezawas, Beth A. Verchinski, Venkata S. Mattay, Joseph H. Callicott, Bhaskar S. Kolachana, Richard E. Straub, Michael F. Egan, Andreas Meyer-Lindenberg, andDaniel R. Weinberger Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-1379
A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.
Key words: Alzheimer; Down syndrome; gene; Huntington; memory; morphometry; neurotrophic; schizophrenia; BDNF; voxel-based; VBM; imaging genomics
Received July 6, 2004; revised September 21, 2004; accepted September 23, 2004.
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