WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience MBF Stereo Investigator
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, December 1, 2004, 24(48):10908-10917; doi:10.1523/JNEUROSCI.3987-04.2004

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (34)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Camacho, I. E.
Right arrow Articles by De Strooper, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Camacho, I. E.
Right arrow Articles by De Strooper, B.

 Previous Article  |  Next Article 

Neurobiology of Disease
Peroxisome Proliferator-Activated Receptor {gamma} Induces a Clearance Mechanism for the Amyloid-{beta} Peptide

Ira Espuny Camacho,1 Lutgarde Serneels,1 Kurt Spittaels,2 Pascal Merchiers,2 Diana Dominguez,1 and Bart De Strooper1

1Neuronal Cell Biology and Gene Transfer Laboratory, Center for Human Genetics, Vlaams Interuniversitair Instituut voor Biotechnologie and Katholieke Universiteit Leuven, 3000 Leuven, Belgium, and 2Galapagos Genomics NV, 2800 Mechelen, Belgium

We investigated whether peroxisome proliferator-activated receptor {gamma} (PPAR{gamma}) could be involved in the modulation of the amyloid cascade causing Alzheimer's disease. Inducing expression or activating PPAR{gamma} using synthetic agonists of the thiazolinedione family results in a dramatic decrease in the levels of the amyloid-{beta} (A{beta}) peptide in the conditioned medium of neuronal and non-neuronal cells. PPAR{gamma} does not affect expression or activity of any of the secretases involved in the generation of the A{beta} peptide but induces a fast, cell-bound clearing mechanism responsible for the removal of the A{beta} peptide from the medium. Although PPAR{gamma} expression is generally low in the CNS, induction of PPAR{gamma} expression during inflammation could be beneficial for inducing A{beta} clearance. We confirm that the A{beta} clearance mechanism can indeed be induced by PPAR{gamma} activation in primary murine-mixed glia and cortical neuronal cultures. Our results suggest that PPAR{gamma}-controlled mechanisms should be explored further as potential drug targets for Alzheimer's disease treatment.

Key words: PPAR{gamma}; TZD; A{beta}; APP; NSAIDs; Alzheimer's disease

Received April 24, 2004; revised October 20, 2004; accepted October 20, 2004.




This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
C. T. Kodl and E. R. Seaquist
Cognitive Dysfunction and Diabetes Mellitus
Endocr. Rev., June 1, 2008; 29(4): 494 - 511.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
K. Wang and Y.-J. Y. Wan
Nuclear Receptors and Inflammatory Diseases
Experimental Biology and Medicine, May 1, 2008; 233(5): 496 - 506.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
B. P. Imbimbo, E. Del Giudice, D. Colavito, A. D'Arrigo, M. D. Carbonare, G. Villetti, F. Facchinetti, R. Volta, V. Pietrini, M. F. Baroc, et al.
1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic Acid (CHF5074), a Novel {gamma}-Secretase Modulator, Reduces Brain beta-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease without Causing Peripheral Toxicity
J. Pharmacol. Exp. Ther., December 1, 2007; 323(3): 822 - 830.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. R. Romito-DiGiacomo, H. Menegay, S. A. Cicero, and K. Herrup
Effects of Alzheimer's Disease on Different Cortical Layers: The Role of Intrinsic Differences in A{beta} Susceptibility
J. Neurosci., August 8, 2007; 27(32): 8496 - 8504.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. Luna-Medina, M. Cortes-Canteli, S. Sanchez-Galiano, J. A. Morales-Garcia, A. Martinez, A. Santos, and A. Perez-Castillo
NP031112, a Thiadiazolidinone Compound, Prevents Inflammation and Neurodegeneration under Excitotoxic Conditions: Potential Therapeutic Role in Brain Disorders
J. Neurosci., May 23, 2007; 27(21): 5766 - 5776.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
R Bordet, P Gele, P Duriez, and J-C Fruchart
PPARs: a new target for neuroprotection.
J. Neurol. Neurosurg. Psychiatry, March 1, 2006; 77(3): 285 - 287.
[Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Sastre, I. Dewachter, S. Rossner, N. Bogdanovic, E. Rosen, P. Borghgraef, B. O. Evert, L. Dumitrescu-Ozimek, D. R. Thal, G. Landreth, et al.
Nonsteroidal anti-inflammatory drugs repress {beta}-secretase gene promoter activity by the activation of PPAR{gamma}
PNAS, January 10, 2006; 103(2): 443 - 448.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-