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The Journal of Neuroscience, December 1, 2004, 24(48):10950-10962; doi:10.1523/JNEUROSCI.3749-04.2004

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Cellular/Molecular
Frequency-Dependent Modulation of Retinogeniculate Transmission by Serotonin

Daniel P. Seeburg,¹ Xiaojin Liu,² and Chinfei Chen²

¹MD-PhD Program, Harvard Medical School, and ²Division of Neuroscience, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115

The relay of visual information converging in the lateral geniculate nucleus (LGN) en route to the visual cortex is modulated by projections from brainstem nuclei. The release of serotonin, one mediator of these effects, has been shown to act at a presynaptic site to inhibit neurotransmitter release at the retinogeniculate synapse, the connection between retinal ganglion cells and thalamocortical relay neurons in the LGN. To understand how serotonergic inhibition of synaptic transmission influences the transfer of information at this synapse, we examined the EPSCs and firing responses of relay neurons to 5-carboxytryptamine (5-CT), a 5-HT₁ receptor agonist that preferentially activates the presynaptic over postsynaptic modulatory effects of serotonin. Bath application of 5-CT inhibits synaptic strength, relieves synaptic depression, and reduces the total synaptic charge transferred at the retinogeniculate synapse in mouse LGN brain slices. In contrast, 5-CT does not significantly alter the membrane potential response of relay neurons to trains of intracellular current injections. Here we show that presynaptic serotonergic modulation results in a frequency-dependent inhibition of relay neuron firing. At low-frequency stimulation, 5-CT markedly reduces charge transfer at the retinogeniculate synapse, thus inhibiting relay neuron firing. However, inhibition of firing by 5-CT is diminished during high-frequency stimulation, because relief from synaptic depression partially offsets the reduction in charge transfer. Thus, presynaptic serotonergic inhibition plays a powerful role in modulating the frequency range of visual information transmitted via the retinogeniculate synapse such that high-frequency inputs are more reliably transmitted than low-frequency inputs.

Key words: serotonin; thalamus; visual system; presynaptic modulation; high-pass filter; sleep

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Received Sep 9, 2004; revised October 22, 2004; accepted October 22, 2004.

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