WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Discover www.zeiss.de/functionality
 QUICK SEARCH:   [advanced]


     
-


HOME
  |  
SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, December 8, 2004, 24(49):11017-11022; doi:10.1523/JNEUROSCI.3321-04.2004

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (55)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hester, R.
Right arrow Articles by Garavan, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hester, R.
Right arrow Articles by Garavan, H.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Executive Dysfunction in Cocaine Addiction: Evidence for Discordant Frontal, Cingulate, and Cerebellar Activity

Robert Hester1 and Hugh Garavan1,2

1Department of Psychology and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland, and 2Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226

Using a GO-NOGO response inhibition task in which working memory (WM) demands can be varied, we demonstrate that the compromised abilities of cocaine users to exert control over strong prepotent urges are associated with reduced activity in anterior cingulate and right prefrontal cortices, two regions thought to be critical for implementing cognitive control. Furthermore, unlike drug-naive controls, and opposite to the anterior cingulate pattern, cocaine users showed an over-reliance on the left cerebellum, a compensatory pattern previously seen in alcohol addiction. The results indicate that cocaine users find it difficult to inhibit their own actions, particularly when WM demands, which have been shown previously to increase during cue-induced craving for the drug, are increased. The results reveal a neuroanatomical basis for this dysexecutive component to addiction, supporting the suggested importance cognitive functions may play in prolonging abuse or predisposing users toward relapse.

Key words: cocaine; executive function; response inhibition; working memory; addiction; fMRI


Received July 6, 2004; revised September 24, 2004; accepted October 3, 2004.




This article has been cited by other articles:


Home page
Cereb CortexHome page
S. M. Landau, R. Lal, J. P. O'Neil, S. Baker, and W. J. Jagust
Striatal Dopamine and Working Memory
Cereb Cortex, June 11, 2008; (2008) bhn095v1.
[Abstract] [Full Text] [PDF]


Home page
J PsychopharmacolHome page
F. Angelucci, V. Ricci, M. Pomponi, G. Conte, A. A. Mathe, P. Attilio Tonali, and P. Bria
Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor
J Psychopharmacol, November 1, 2007; 21(8): 820 - 825.
[Abstract] [PDF]


Home page
ScienceHome page
J. W. Dalley, T. D. Fryer, L. Brichard, E. S. J. Robinson, D. E. H. Theobald, K. Laane, Y. Pena, E. R. Murphy, Y. Shah, K. Probst, et al.
Nucleus Accumbens D2/3 Receptors Predict Trait Impulsivity and Cocaine Reinforcement
Science, March 2, 2007; 315(5816): 1267 - 1270.
[Abstract] [Full Text] [PDF]


Home page
Br. J. PsychiatryHome page
P. R. Szeszko, D. G. Robinson, S. Sevy, S. Kumra, C. I. Rupp, J. D. Betensky, T. Lencz, M. Ashtari, J. M. Kane, A. K. Malhotra, et al.
Anterior cingulate grey-matter deficits and cannabis use in first-episode schizophrenia
The British Journal of Psychiatry, March 1, 2007; 190(3): 230 - 236.
[Abstract] [Full Text] [PDF]


Home page
Am. J. PsychiatryHome page
R. Z. Goldstein, N. Alia-Klein, D. Tomasi, L. Zhang, L. A. Cottone, T. Maloney, F. Telang, E. C. Caparelli, L. Chang, T. Ernst, et al.
Is Decreased Prefrontal Cortical Sensitivity to Monetary Reward Associated With Impaired Motivation and Self-Control in Cocaine Addiction?
Am J Psychiatry, January 1, 2007; 164(1): 43 - 51.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
H. Homayoun and B. Moghaddam
Progression of Cellular Adaptations in Medial Prefrontal and Orbitofrontal Cortex in Response to Repeated Amphetamine
J. Neurosci., August 2, 2006; 26(31): 8025 - 8039.
[Abstract] [Full Text] [PDF]


Home page
Am. J. PsychiatryHome page
K. Murphy, V. Dixon, K. LaGrave, J. Kaufman, R. Risinger, A. Bloom, and H. Garavan
A Validation of Event-Related fMRI Comparisons Between Users of Cocaine, Nicotine, or Cannabis and Control Subjects
Am J Psychiatry, July 1, 2006; 163(7): 1245 - 1251.
[Abstract] [Full Text] [PDF]


Home page
Alcohol AlcoholHome page
G. DOM, B. DE WILDE, W. HULSTIJN, W. VAN DEN BRINK, and B. SABBE
BEHAVIOURAL ASPECTS OF IMPULSIVITY IN ALCOHOLICS WITH AND WITHOUT A CLUSTER-B PERSONALITY DISORDER
Alcohol Alcohol., July 1, 2006; 41(4): 412 - 420.
[Abstract] [Full Text] [PDF]



-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help

-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-