QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, December 8, 2004, 24(49):11029-11034; doi:10.1523/JNEUROSCI.3968-04.2004

This Article Full Text Full Text (PDF) Supplemental data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (28) Citing Articles via Google Scholar Google Scholar Articles by Yang, C.-H. Articles by Hsu, K.-S. Search for Related Content PubMed PubMed Citation Articles by Yang, C.-H. Articles by Hsu, K.-S.

 Previous Article  |  Next Article 

BRIEF COMMUNICATION
Behavioral Stress Modifies Hippocampal Synaptic Plasticity through Corticosterone-Induced Sustained Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Activation

Chih-Hao Yang,^1,2 Chiung-Chun Huang,¹ and Kuei-Sen Hsu^1,2

¹Department of Pharmacology and ²Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan

The induction of hippocampal long-term synaptic plasticity is exquisitely sensitive to behavioral stress, but the underlying mechanisms are still unclear. We report here that hippocampal slices prepared from adult rats that had experienced unpredictable and inescapable restraint tail-shock stress showed marked impairments of long-term potentiation (LTP) in the CA1 region. The same stress promoted the induction of long-term depression (LTD). These effects were prevented when the animals were given the glucocorticoid receptor antagonist 11, 17-11[4-(dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)-estra-4-9-dien-3-one before the stress. Immunoblotting analyses revealed that stress induced a profound and prolonged extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK1/2 MAPK) hyperphosphorylation through small GTPase Ras, Raf-1, and MAPK kinase 1/2 (MEK1/2). Furthermore, the stress effects were obviated by the intrahippocampal injection of specific inhibitors of MEK1/2 (U0126), protein kinase C (bisindolylmaleimide I), tyrosine kinase (K252a), and BDNF antisense oligonucleotides. These results suggest that the effects of stress on LTP and LTD originate from the corticosterone-induced sustained activation of ERK1/2-coupled signaling cascades.

Key words: stress; long-term potentiation; long-term depression; extracellular signal-related kinase; mitogen-activated protein kinase; glucocorticoid receptor; hippocampus

---

Received May 12, 2004; revised October 29, 2004; accepted October 29, 2004.

This article has been cited by other articles:

				E. Bay and Y. Xie Psychological and Biological Correlates of Fatigue After Mild-to-Moderate Traumatic Brain Injury West J Nurs Res, October 1, 2009; 31(6): 731 - 747. [Abstract] [PDF]

				S-T HONG, C-B CHOI, C PARK, H-Y MOON, K S HONG, C CHEONG, J-H CHAE, and B-Y CHOE Specific hippocampal choline decrease in an animal model of depression Br. J. Radiol., July 1, 2009; 82(979): 549 - 553. [Abstract] [Full Text] [PDF]

				N. Maggio and M. Segal Differential Corticosteroid Modulation of Inhibitory Synaptic Currents in the Dorsal and Ventral Hippocampus J. Neurosci., March 4, 2009; 29(9): 2857 - 2866. [Abstract] [Full Text] [PDF]

				E. Bay, A. Sikorskii, and Fuli Gao Functional Status, Chronic Stress, and Cortisol Response After Mild-to-Moderate Traumatic Brain Injury Biol Res Nurs, January 1, 2009; 10(3): 213 - 225. [Abstract] [PDF]

				S. Rossi, V. De Chiara, A. Musella, H. Kusayanagi, G. Mataluni, G. Bernardi, A. Usiello, and D. Centonze Chronic Psychoemotional Stress Impairs Cannabinoid-Receptor-Mediated Control of GABA Transmission in the Striatum J. Neurosci., July 16, 2008; 28(29): 7284 - 7292. [Abstract] [Full Text] [PDF]

				P.-C. Yang, C.-H. Yang, C.-C. Huang, and K.-S. Hsu Phosphatidylinositol 3-Kinase Activation Is Required for Stress Protocol-induced Modification of Hippocampal Synaptic Plasticity J. Biol. Chem., February 1, 2008; 283(5): 2631 - 2643. [Abstract] [Full Text] [PDF]

				F. Chaouloff, A. Hemar, and O. Manzoni Acute Stress Facilitates Hippocampal CA1 Metabotropic Glutamate Receptor-Dependent Long-Term Depression J. Neurosci., July 4, 2007; 27(27): 7130 - 7135. [Abstract] [Full Text] [PDF]

				N. Maggio and M. Segal Striking Variations in Corticosteroid Modulation of Long-Term Potentiation along the Septotemporal Axis of the Hippocampus J. Neurosci., May 23, 2007; 27(21): 5757 - 5765. [Abstract] [Full Text] [PDF]

				D. N. Mayorov Brain superoxide as a key regulator of the cardiovascular response to emotional stress in rabbits Exp Physiol, May 1, 2007; 92(3): 471 - 479. [Abstract] [Full Text] [PDF]

				C.-C. Huang, P.-C. Yang, H.-J. Lin, and K.-S. Hsu Repeated Cocaine Administration Impairs Group II Metabotropic Glutamate Receptor-Mediated Long-Term Depression in Rat Medial Prefrontal Cortex J. Neurosci., March 14, 2007; 27(11): 2958 - 2968. [Abstract] [Full Text] [PDF]

				C.-H. Yang, C.-C. Huang, and K.-S. Hsu Novelty exploration elicits a reversal of acute stress-induced modulation of hippocampal synaptic plasticity in the rat J. Physiol., December 1, 2006; 577(2): 601 - 615. [Abstract] [Full Text] [PDF]

				T. Ahmed, J. U. Frey, and V. Korz Long-Term Effects of Brief Acute Stress on Cellular Signaling and Hippocampal LTP J. Neurosci., April 12, 2006; 26(15): 3951 - 3958. [Abstract] [Full Text] [PDF]

				C.-H. Yang, C.-C. Huang, and K.-S. Hsu Behavioral Stress Enhances Hippocampal CA1 Long-Term Depression through the Blockade of the Glutamate Uptake J. Neurosci., April 27, 2005; 25(17): 4288 - 4293. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help