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The Journal of Neuroscience, February 4, 2004, 24(5):1005-1012; doi:10.1523/JNEUROSCI.4698-03.2004
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Neurobiology of Disease
Acid-Sensing Ion Channel 2 Is Important for Retinal Function and Protects against Light-Induced Retinal Degeneration
Mohamed Ettaiche,1 Nicolas Guy,1 Paul Hofman,2 Michel Lazdunski,1 andRainer Waldmann1 1Institute of Molecular and Cellular Pharmacology, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6097, Sophia-Antipolis, 06560 Valbonne, France, and 2Faculty of Medicine, Institut National de la Santé et de la Recherche Médicale EPI 02–15, Immunité des Muqueuses et Vaccination, 06107 Nice Cedex, France
pH variations in the retina are thought to be involved in the fine-tuning of visual perception. We show that both photoreceptors and neurons of the mouse retina express the H+-gated cation channel subunits acid-sensing ion channel 2a (ASIC2a) and ASIC2b. Inactivation of the ASIC2 gene in mice leads to an increase in the rod electroretinogram a- and b-waves and thus to an enhanced gain of visual transduction. ASIC2 knock-out mice are also more sensitive to light-induced retinal degeneration. We suggest that ASIC2 is a negative modulator of rod phototransduction, and that functional ASIC2 channels are beneficial for the maintenance of retinal integrity.
Key words: proton-gated channels; ASIC2; vision; rods; acid; neurotransmission; retinal degeneration
Received May 21, 2003; revised December 1, 2003; accepted December 2, 2003.
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